Research output per year
Research output per year
Personal profile
Current courses
Click here for my courses.
Research interests
With a background in both clinical neuropsychology and cognitive neuroscience I aim to build bridges between cognitive neurosciences, medical sciences and clinical practice. I strive to increase our mechanistic understanding of neural mechanisms underlying fatigue-related symptoms and cognitive difficulties in disease to ultimately improve its assessment as well as its pharmacological and behavioural treatment and prevention.
To this end I study the role of immune-brain interactions in the emergence and maintenance of fatigue and cognitive symptoms in disease. For this combine neuroimaging with immune, pharmacological and behavioural manipulations in healthy populations, and assess the links between immune-metabolic, neuroimaging (MRI) and (online) cognitive measurement in various diseases, including cancer, aquired brain injury, MECFS and POST-COVID. Usng this knowledge I also aim to improve neurocognitive assesment of flutuations in cognitive functioning with ecological momentary sampling.
Research interests
I teach the course "Intrduction to neuropsychology ", 2nd year Psychology and LAS bachelor
Yearly I supervise 12-16 Bachelor and Master students. Projects include:
- Sick for science: investigating individual variation in sickness symptoms during an acute systemic immune challange (Lipopolysacharide)
- Cancer-related fatigue - A sicknes behaviour approach: Investigating fatigue as a change in motivational decision making in testicular cancer survivors.
Education/Academic qualification
PhD, Dopaminergic modulation of reward and punishment learning, Radboud Univ Nijmegen, Radboud University Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav
Award Date: 11 Jul 2014
External positions
Guest Researcher, Donders Centre for Cognitive Neuroimaging
1 Jan 2023 → …
Guest reseracher, Radboud University Medical Center
1 Jan 2023 → …
Editorial board member, Neuroimmunomodulation
1 Jan 2022 → …
Keywords
- Fatigue
- immune-brain interactions
- Dopamine
- effort-based decicion making
- Fatigue-related Cognition
- Post-COVID fatigue
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Greater fatigue is more strongly associated with reduced reward sensitivity in the long-term phase of coronavirus disease (COVID-19) than in the early phase
Scholing, J. M., Lambregts, B. I. H. M., van den Bosch, R., Aarts, E. & van der Schaaf, M. E., Oct 2025, In: Brain, Behavior and Immunity - Health. 48, 14 p., 101056.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile4 Downloads (Pure) -
Disentangling pain and fatigue in chronic fatigue syndrome: a resting state connectivity study before and after cognitive behavioral therapy
van der Schaaf, M. E., Geerligs, L., Toni, I., Knoop, H. & Oosterman, J. M., Jun 2024, In: Psychological Medicine. 54, 8, p. 1735-1748 14 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile1 Downloads (Pure) -
Fatigue during acute systemic inflammation is associated with reduced mental effort expenditure while task accuracy is preserved
Lambregts, B. I. H. M., Vassena, E., Jansen, A., Stremmelaar, D. E., Pickkers, P., Kox, M., Aarts, E. & van der Schaaf, M. E., 2023, In: Brain, Behavior, and Immunity: An international journal. 112, p. 235-245Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile2 Link opens in a new tab Citations (Scopus)112 Downloads (Pure) -
Acquisition learning is stronger for aversive than appetitive events
van der Schaaf, M. E., Schmidt, K., Kaur, J., Gamer, M., Wiech, K., Forkmann, K. & Bingel, U., 4 Apr 2022, In: Communications biology. 5, 1, p. 302Research output: Contribution to journal › Article › Scientific › peer-review
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Catecholaminergic modulation of trust decisions
Rățală, C. E., Fallon, S. J., van der Schaaf, M. E., Ter Huurne, N., Cools, R. & Sanfey, A. G., Jun 2019, In: Psychopharmacology. 236, 6, p. 1807-1816 10 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
Projects
- 2 Active
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Investigating Metabolic and Neuropathological interactions to Address Cognitive Symptoms in ME/CFS
van der Schaaf, M. (Principal Investigator)
1/01/26 → 31/12/29
Project: Research project
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Cognitive ecological momentary assessment: Bridging the gap between self-reported and neuropsychologically-tested cognitive functioning
van der Schaaf, M. (Co-Investigator)
1/10/25 → 1/10/27
Project: Research project