Chemotherapy-induced peripheral neuropathy; its impact on colorectal cancer patients’ lives

Project: Research project

Project Details


Objective: We aim to gain insight into the prevalence and severity of CIPN and its influence on patient-reported outcomes (i.e. health related quality of life (HRQoL), disease-specific complaints, depression, fatigue, sleep problems) among a prospective population-based sample of colorectal cancer (CRC) patients. We choose to focus on this group of cancer patients since this is a relatively large group that is at risk for CIPN. Furthermore, we will study the role of personality characteristics (e.g. Optimism, Type D personality, mindfulness, illness perception) on CIPN experience and we will investigate the influence of CIPN on health care utilisation, physical activity, and employment. Finally, we will investigate the role of genetic/biological markers of inflammation on HRQOL and pain among patients with CIPN. Genetic polymorphisms and gene expression assessed will involve: pro- and anti-inflammatory cytokines (IL-1β, IL-6, TNF-α, IL-RN, and IL-10).
Study design: We performed a prospective population-based study in which we included CRC patients before the start of treatment and followed them until 2 years after treatment. Patients from 4 hospitals were asked to fill out questionnaires on CIPN, HRQoL, depression, fatigue, sleep problems, personality characteristics, health care utilisation, physical activity, health supplements use, and employment at 4 points in time (before surgery, within a month after surgery (e.g. before chemotherapy), within a month after chemotherapy (e.g. one year after diagnosis), and 2 years after diagnosis. Clinical data like disease stage, cumulative dose of chemotherapy and dose reductions were extracted from patients’ medical records and the Netherlands Cancer Registry. All participants were asked to donate a blood sample 3 times (2X10 ml, 10 minutes) in order to examine the association between HRQOL, pain, genetic and biological markers of inflammation. The blood draws took place at the 4 hospitals
StatusNot started


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