Personalizing treatment for chronic cancer-related fatigue

Project: Research project

Project Details

Description

Researchers from the Helen Dowling Institute (HDI) and Tilburg University are collaborating in a project to explore what treatment works best for the individual cancer patient suffering from chronic fatigue. One in three cancer patients suffer from severe fatigue up till months and even years after successful treatment. As the number of cancer survivors is rapidly growing, we are in need of highly effective treatments. Currently, we do not know which of treatment is most effective for the individual patient.

Chronic cancer-related fatigue

One of the most prevalent side effects of cancer and its treatment is fatigue. It is characterized by feelings of weakness, exhaustion and lack of energy. One third of cancer patients suffer from severe fatigue up till months and even years after successful treatment. This persistent fatigue, which is defined as Chronic Cancer-Related Fatigue (CCRF), is a complex, multifactorial condition that is often accompanied by significant distress and reduces patients’ quality of life. As the number of cancer survivors is expected to increase considerably in the next years, the need for highly effective treatments will become even more pressing. While existing treatment options can be effective, we do not know which (combination) of treatment is most effective for the individual patient.

The REFINE project

In the REFINE project, funded by the Dutch Cancer Society, we will explore what treatment is most effective for the individual patient suffering from chronic cancer-related fatigue. By taking the network approach and focusing on the patient perspective we hope to contribute to more personalized and precise treatment for cancer patients.

The plan

First, we will examine group-level networks to identify important risk and protective factors that are related to fatigue. At the same time we will conduct qualitative research to explore the patient’s perspective on what they experience as helpful when handling fatigue. Next, we will use the input from these studies to set up an ESM (experience sampling method) study and explore individual dynamic networks of cancer-related fatigue. We want to explore whether these networks can help patients and therapists to decide what treatment would be most beneficial for them.
Short titleREFINE project
StatusNot started

Research Output

Exploring the interconnectedness of fatigue, depression, anxiety and potential risk and protective factors in cancer patients: A network approach

Schellekens, M., Wolvers, M., Schroevers, M., Bootsma, T., Cramer, A. & van der Lee, M. L., 2020, In : Journal of Behavioral Medicine.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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    Experiencing and responding to chronic cancer-related fatigue: A meta-ethnography of qualitative research

    Bootsma, T. I., Schellekens, M. P. J., van Woezik, R. A. M., van der Lee, M. L. & Slatman, J., 10 Sep 2019, In : Psycho-Oncology. 10 p.

    Research output: Contribution to journalReview articleScientificpeer-review

    Open Access