A pilot randomized controlled trial of exercise to improve cognitive performance in patients with stable glioma: A proof of concept

Karin Gehring*, Martijn M Stuiver, Eva Visser, Corelien Kloek, Martin van den Bent, Monique Hanse, Cees Tijssen, Geert-Jan Rutten, Martin J B Taphoorn, Neil K Aaronson, Margriet M Sitskoorn

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

1 Downloads (Pure)

Abstract

Background: 

Patients with glioma often suffer from cognitive deficits. Physical exercise has been effective in ameliorating cognitive deficits in older adults and neurological patients. This pilot randomized controlled trial (RCT) explored the possible impact of an exercise intervention, designed to improve cognitive functioning in glioma patients, regarding cognitive test performance and patient-reported outcomes (PROs).

Methods: 

Thirty-four clinically stable patients with World Health Organization grades II/III glioma were randomized to a home-based remotely coached exercise group or an active control group. Patients exercised 3 times per week for 20-45 minutes, with moderate to vigorous intensity, during 6 months. At baseline and immediate follow-up, cognitive performance and PROs were assessed with neuropsychological tests and questionnaires, respectively. Linear regression analyses were used to estimate effect sizes of potential between-group differences in cognitive performance and PROs at 6 months.

Results: 

The exercise group (n = 21) had small- to medium-sized better follow-up scores than the control group (n = 11) on several measures of attention and information processing speed, verbal memory, and executive function, whereas the control group showed a slightly better score on a measure of sustained selective attention. The exercise group also demonstrated small- to medium-sized better outcomes on measures of self-reported cognitive symptoms, fatigue, sleep, mood, and mental health-related quality of life.

Conclusions: 

This small exploratory RCT in glioma patients provides a proof of concept with respect to improvement of cognitive functioning and PROs after aerobic exercise, and warrants larger exercise trials in brain tumor patients.

Original languageEnglish
Pages (from-to)103-115
JournalNeuro-Oncology
Volume22
Issue number1
DOIs
Publication statusPublished - 2020

Fingerprint

Glioma
Exercise
Executive Function
Linear Models
Mental Health

Cite this

Gehring, Karin ; Stuiver, Martijn M ; Visser, Eva ; Kloek, Corelien ; van den Bent, Martin ; Hanse, Monique ; Tijssen, Cees ; Rutten, Geert-Jan ; Taphoorn, Martin J B ; Aaronson, Neil K ; Sitskoorn, Margriet M. / A pilot randomized controlled trial of exercise to improve cognitive performance in patients with stable glioma : A proof of concept. In: Neuro-Oncology. 2020 ; Vol. 22, No. 1. pp. 103-115.
@article{a2c759b3883e4163a4a002097ae3aac3,
title = "A pilot randomized controlled trial of exercise to improve cognitive performance in patients with stable glioma: A proof of concept",
abstract = "Background: Patients with glioma often suffer from cognitive deficits. Physical exercise has been effective in ameliorating cognitive deficits in older adults and neurological patients. This pilot randomized controlled trial (RCT) explored the possible impact of an exercise intervention, designed to improve cognitive functioning in glioma patients, regarding cognitive test performance and patient-reported outcomes (PROs).Methods: Thirty-four clinically stable patients with World Health Organization grades II/III glioma were randomized to a home-based remotely coached exercise group or an active control group. Patients exercised 3 times per week for 20-45 minutes, with moderate to vigorous intensity, during 6 months. At baseline and immediate follow-up, cognitive performance and PROs were assessed with neuropsychological tests and questionnaires, respectively. Linear regression analyses were used to estimate effect sizes of potential between-group differences in cognitive performance and PROs at 6 months.Results: The exercise group (n = 21) had small- to medium-sized better follow-up scores than the control group (n = 11) on several measures of attention and information processing speed, verbal memory, and executive function, whereas the control group showed a slightly better score on a measure of sustained selective attention. The exercise group also demonstrated small- to medium-sized better outcomes on measures of self-reported cognitive symptoms, fatigue, sleep, mood, and mental health-related quality of life.Conclusions: This small exploratory RCT in glioma patients provides a proof of concept with respect to improvement of cognitive functioning and PROs after aerobic exercise, and warrants larger exercise trials in brain tumor patients.",
author = "Karin Gehring and Stuiver, {Martijn M} and Eva Visser and Corelien Kloek and {van den Bent}, Martin and Monique Hanse and Cees Tijssen and Geert-Jan Rutten and Taphoorn, {Martin J B} and Aaronson, {Neil K} and Sitskoorn, {Margriet M}",
year = "2020",
doi = "10.1093/neuonc/noz178",
language = "English",
volume = "22",
pages = "103--115",
journal = "Neuro-Oncology",
issn = "1522-8517",
publisher = "OXFORD UNIV PRESS INC",
number = "1",

}

Gehring, K, Stuiver, MM, Visser, E, Kloek, C, van den Bent, M, Hanse, M, Tijssen, C, Rutten, G-J, Taphoorn, MJB, Aaronson, NK & Sitskoorn, MM 2020, 'A pilot randomized controlled trial of exercise to improve cognitive performance in patients with stable glioma: A proof of concept', Neuro-Oncology, vol. 22, no. 1, pp. 103-115. https://doi.org/10.1093/neuonc/noz178

A pilot randomized controlled trial of exercise to improve cognitive performance in patients with stable glioma : A proof of concept. / Gehring, Karin; Stuiver, Martijn M; Visser, Eva; Kloek, Corelien; van den Bent, Martin; Hanse, Monique; Tijssen, Cees; Rutten, Geert-Jan; Taphoorn, Martin J B; Aaronson, Neil K; Sitskoorn, Margriet M.

In: Neuro-Oncology, Vol. 22, No. 1, 2020, p. 103-115.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - A pilot randomized controlled trial of exercise to improve cognitive performance in patients with stable glioma

T2 - A proof of concept

AU - Gehring, Karin

AU - Stuiver, Martijn M

AU - Visser, Eva

AU - Kloek, Corelien

AU - van den Bent, Martin

AU - Hanse, Monique

AU - Tijssen, Cees

AU - Rutten, Geert-Jan

AU - Taphoorn, Martin J B

AU - Aaronson, Neil K

AU - Sitskoorn, Margriet M

PY - 2020

Y1 - 2020

N2 - Background: Patients with glioma often suffer from cognitive deficits. Physical exercise has been effective in ameliorating cognitive deficits in older adults and neurological patients. This pilot randomized controlled trial (RCT) explored the possible impact of an exercise intervention, designed to improve cognitive functioning in glioma patients, regarding cognitive test performance and patient-reported outcomes (PROs).Methods: Thirty-four clinically stable patients with World Health Organization grades II/III glioma were randomized to a home-based remotely coached exercise group or an active control group. Patients exercised 3 times per week for 20-45 minutes, with moderate to vigorous intensity, during 6 months. At baseline and immediate follow-up, cognitive performance and PROs were assessed with neuropsychological tests and questionnaires, respectively. Linear regression analyses were used to estimate effect sizes of potential between-group differences in cognitive performance and PROs at 6 months.Results: The exercise group (n = 21) had small- to medium-sized better follow-up scores than the control group (n = 11) on several measures of attention and information processing speed, verbal memory, and executive function, whereas the control group showed a slightly better score on a measure of sustained selective attention. The exercise group also demonstrated small- to medium-sized better outcomes on measures of self-reported cognitive symptoms, fatigue, sleep, mood, and mental health-related quality of life.Conclusions: This small exploratory RCT in glioma patients provides a proof of concept with respect to improvement of cognitive functioning and PROs after aerobic exercise, and warrants larger exercise trials in brain tumor patients.

AB - Background: Patients with glioma often suffer from cognitive deficits. Physical exercise has been effective in ameliorating cognitive deficits in older adults and neurological patients. This pilot randomized controlled trial (RCT) explored the possible impact of an exercise intervention, designed to improve cognitive functioning in glioma patients, regarding cognitive test performance and patient-reported outcomes (PROs).Methods: Thirty-four clinically stable patients with World Health Organization grades II/III glioma were randomized to a home-based remotely coached exercise group or an active control group. Patients exercised 3 times per week for 20-45 minutes, with moderate to vigorous intensity, during 6 months. At baseline and immediate follow-up, cognitive performance and PROs were assessed with neuropsychological tests and questionnaires, respectively. Linear regression analyses were used to estimate effect sizes of potential between-group differences in cognitive performance and PROs at 6 months.Results: The exercise group (n = 21) had small- to medium-sized better follow-up scores than the control group (n = 11) on several measures of attention and information processing speed, verbal memory, and executive function, whereas the control group showed a slightly better score on a measure of sustained selective attention. The exercise group also demonstrated small- to medium-sized better outcomes on measures of self-reported cognitive symptoms, fatigue, sleep, mood, and mental health-related quality of life.Conclusions: This small exploratory RCT in glioma patients provides a proof of concept with respect to improvement of cognitive functioning and PROs after aerobic exercise, and warrants larger exercise trials in brain tumor patients.

U2 - 10.1093/neuonc/noz178

DO - 10.1093/neuonc/noz178

M3 - Article

C2 - 31755917

VL - 22

SP - 103

EP - 115

JO - Neuro-Oncology

JF - Neuro-Oncology

SN - 1522-8517

IS - 1

ER -