A randomised controlled trial of positive memory training for the treatment of depression within schizophrenia

Craig Steel, Mark van der Gaag, Kees Korrelboom, Judit Simon, Peter Phiri, M. Fazil Baksh, Til Wykes, Diana Rose, Suzanna Rose, Mark Hardcastle, Simon Enright, Gareth Evans, David Kingdon

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Abstract

Background
Depression is highly prevalent within individuals diagnosed with schizophrenia, and is associated with an increased risk of suicide. There are no current evidence based treatments for low mood within this group. The specific targeting of co-morbid conditions within complex mental health problems lends itself to the development of short-term structured interventions which are relatively easy to disseminate within health services. A brief cognitive intervention based on a competitive memory theory of depression, is being evaluated in terms of its effectiveness in reducing depression within this group.
Methods/Design
This is a single blind, intention-to-treat, multi-site, randomized controlled trial comparing Positive Memory Training plus Treatment as Usual with Treatment as Usual alone. Participants will be recruited from two NHS Trusts in Southern England. In order to be eligible, participants must have a DSM-V diagnosis of schizophrenia or schizo-affective disorder and exhibit at least a mild level of depression. Following baseline assessment eligible participants will be randomly allocated to either the Positive Memory Training plus Treatment as Usual group or the Treatment as Usual group. Outcome will be assessed at the end of treatment (3-months) and at 6-month and 9-month post randomization by assessors blind to group allocation. The primary outcome will be levels of depression and secondary outcomes will be severity of psychotic symptoms and cost-effectiveness. Semi-structured interviews will be conducted with all participants who are allocated to the treatment group so as to explore the acceptability of the intervention.
Discussion
Cognitive behaviour therapy is recommended for individuals diagnosed with schizophrenia. However, the number of sessions and length of training required to deliver this intervention has caused a limit in availability. The current trial will evaluate a short-term structured protocol which targets a co-morbid condition often considered of primary importance by service users. If successful the intervention will be an important addition to current initiatives aimed at increasing access to psychological therapies for people diagnosed with severe mental health problems.
Original languageEnglish
Article number85
JournalBMC Psychiatry
Volume15
DOIs
Publication statusPublished - 14 Apr 2015

Cite this

Steel, Craig ; van der Gaag, Mark ; Korrelboom, Kees ; Simon, Judit ; Phiri, Peter ; Baksh, M. Fazil ; Wykes, Til ; Rose, Diana ; Rose, Suzanna ; Hardcastle, Mark ; Enright, Simon ; Evans, Gareth ; Kingdon, David. / A randomised controlled trial of positive memory training for the treatment of depression within schizophrenia. In: BMC Psychiatry. 2015 ; Vol. 15.
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title = "A randomised controlled trial of positive memory training for the treatment of depression within schizophrenia",
abstract = "BackgroundDepression is highly prevalent within individuals diagnosed with schizophrenia, and is associated with an increased risk of suicide. There are no current evidence based treatments for low mood within this group. The specific targeting of co-morbid conditions within complex mental health problems lends itself to the development of short-term structured interventions which are relatively easy to disseminate within health services. A brief cognitive intervention based on a competitive memory theory of depression, is being evaluated in terms of its effectiveness in reducing depression within this group.Methods/DesignThis is a single blind, intention-to-treat, multi-site, randomized controlled trial comparing Positive Memory Training plus Treatment as Usual with Treatment as Usual alone. Participants will be recruited from two NHS Trusts in Southern England. In order to be eligible, participants must have a DSM-V diagnosis of schizophrenia or schizo-affective disorder and exhibit at least a mild level of depression. Following baseline assessment eligible participants will be randomly allocated to either the Positive Memory Training plus Treatment as Usual group or the Treatment as Usual group. Outcome will be assessed at the end of treatment (3-months) and at 6-month and 9-month post randomization by assessors blind to group allocation. The primary outcome will be levels of depression and secondary outcomes will be severity of psychotic symptoms and cost-effectiveness. Semi-structured interviews will be conducted with all participants who are allocated to the treatment group so as to explore the acceptability of the intervention.DiscussionCognitive behaviour therapy is recommended for individuals diagnosed with schizophrenia. However, the number of sessions and length of training required to deliver this intervention has caused a limit in availability. The current trial will evaluate a short-term structured protocol which targets a co-morbid condition often considered of primary importance by service users. If successful the intervention will be an important addition to current initiatives aimed at increasing access to psychological therapies for people diagnosed with severe mental health problems.",
author = "Craig Steel and {van der Gaag}, Mark and Kees Korrelboom and Judit Simon and Peter Phiri and Baksh, {M. Fazil} and Til Wykes and Diana Rose and Suzanna Rose and Mark Hardcastle and Simon Enright and Gareth Evans and David Kingdon",
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Steel, C, van der Gaag, M, Korrelboom, K, Simon, J, Phiri, P, Baksh, MF, Wykes, T, Rose, D, Rose, S, Hardcastle, M, Enright, S, Evans, G & Kingdon, D 2015, 'A randomised controlled trial of positive memory training for the treatment of depression within schizophrenia', BMC Psychiatry, vol. 15, 85. https://doi.org/10.1186/s12888-015-0453-6

A randomised controlled trial of positive memory training for the treatment of depression within schizophrenia. / Steel, Craig; van der Gaag, Mark; Korrelboom, Kees; Simon, Judit; Phiri, Peter; Baksh, M. Fazil; Wykes, Til; Rose, Diana; Rose, Suzanna; Hardcastle, Mark; Enright, Simon; Evans, Gareth; Kingdon, David.

In: BMC Psychiatry, Vol. 15, 85, 14.04.2015.

Research output: Contribution to journalArticleScientificpeer-review

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T1 - A randomised controlled trial of positive memory training for the treatment of depression within schizophrenia

AU - Steel, Craig

AU - van der Gaag, Mark

AU - Korrelboom, Kees

AU - Simon, Judit

AU - Phiri, Peter

AU - Baksh, M. Fazil

AU - Wykes, Til

AU - Rose, Diana

AU - Rose, Suzanna

AU - Hardcastle, Mark

AU - Enright, Simon

AU - Evans, Gareth

AU - Kingdon, David

PY - 2015/4/14

Y1 - 2015/4/14

N2 - BackgroundDepression is highly prevalent within individuals diagnosed with schizophrenia, and is associated with an increased risk of suicide. There are no current evidence based treatments for low mood within this group. The specific targeting of co-morbid conditions within complex mental health problems lends itself to the development of short-term structured interventions which are relatively easy to disseminate within health services. A brief cognitive intervention based on a competitive memory theory of depression, is being evaluated in terms of its effectiveness in reducing depression within this group.Methods/DesignThis is a single blind, intention-to-treat, multi-site, randomized controlled trial comparing Positive Memory Training plus Treatment as Usual with Treatment as Usual alone. Participants will be recruited from two NHS Trusts in Southern England. In order to be eligible, participants must have a DSM-V diagnosis of schizophrenia or schizo-affective disorder and exhibit at least a mild level of depression. Following baseline assessment eligible participants will be randomly allocated to either the Positive Memory Training plus Treatment as Usual group or the Treatment as Usual group. Outcome will be assessed at the end of treatment (3-months) and at 6-month and 9-month post randomization by assessors blind to group allocation. The primary outcome will be levels of depression and secondary outcomes will be severity of psychotic symptoms and cost-effectiveness. Semi-structured interviews will be conducted with all participants who are allocated to the treatment group so as to explore the acceptability of the intervention.DiscussionCognitive behaviour therapy is recommended for individuals diagnosed with schizophrenia. However, the number of sessions and length of training required to deliver this intervention has caused a limit in availability. The current trial will evaluate a short-term structured protocol which targets a co-morbid condition often considered of primary importance by service users. If successful the intervention will be an important addition to current initiatives aimed at increasing access to psychological therapies for people diagnosed with severe mental health problems.

AB - BackgroundDepression is highly prevalent within individuals diagnosed with schizophrenia, and is associated with an increased risk of suicide. There are no current evidence based treatments for low mood within this group. The specific targeting of co-morbid conditions within complex mental health problems lends itself to the development of short-term structured interventions which are relatively easy to disseminate within health services. A brief cognitive intervention based on a competitive memory theory of depression, is being evaluated in terms of its effectiveness in reducing depression within this group.Methods/DesignThis is a single blind, intention-to-treat, multi-site, randomized controlled trial comparing Positive Memory Training plus Treatment as Usual with Treatment as Usual alone. Participants will be recruited from two NHS Trusts in Southern England. In order to be eligible, participants must have a DSM-V diagnosis of schizophrenia or schizo-affective disorder and exhibit at least a mild level of depression. Following baseline assessment eligible participants will be randomly allocated to either the Positive Memory Training plus Treatment as Usual group or the Treatment as Usual group. Outcome will be assessed at the end of treatment (3-months) and at 6-month and 9-month post randomization by assessors blind to group allocation. The primary outcome will be levels of depression and secondary outcomes will be severity of psychotic symptoms and cost-effectiveness. Semi-structured interviews will be conducted with all participants who are allocated to the treatment group so as to explore the acceptability of the intervention.DiscussionCognitive behaviour therapy is recommended for individuals diagnosed with schizophrenia. However, the number of sessions and length of training required to deliver this intervention has caused a limit in availability. The current trial will evaluate a short-term structured protocol which targets a co-morbid condition often considered of primary importance by service users. If successful the intervention will be an important addition to current initiatives aimed at increasing access to psychological therapies for people diagnosed with severe mental health problems.

U2 - 10.1186/s12888-015-0453-6

DO - 10.1186/s12888-015-0453-6

M3 - Article

VL - 15

JO - BMC Psychiatry

JF - BMC Psychiatry

SN - 1471-244X

M1 - 85

ER -