A SNP, gene and polygenic risk score approach of oxytocin-vasopressin genes in adolescents’ loneliness

M. Verhagen, J. M. Vink, K. J. H. Verweij, Gerine Lodder, Luc Goossens, Karine Verschueren, H. Colpin, K. Van Leeuwen, Wim Van den Noortgate, S. Claes, Patricia Bijttebier, E Van Assche

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Not much is known regarding underlying biological pathways to adolescents’ loneliness. Insight in underlying molecular mechanisms could inform intervention efforts aimed at reducing loneliness. Using latent growth curve modeling, baseline levels and development of loneliness were studied in two longitudinal adolescent samples. Genes (OXTR, OXT, AVPR1A, AVPR1B) were examined using SNP‐based, gene‐based, and polygenic risk score (PRS) approaches. In both samples, SNP‐ and gene‐based tests showed involvement of the OXTR gene in development of loneliness, though, significance levels did not survive correction for multiple testing. The PRS approach provided no evidence for relations with loneliness. We recommend alternative phenotyping methods, including environmental factors, to consider epigenetic studies, and to examine possible endophenotypes in relation to adolescents’ loneliness.
Original languageEnglish
JournalJournal of Research on Adolescence
DOIs
Publication statusAccepted/In press - 2019

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Loneliness
Oxytocin
Single Nucleotide Polymorphism
adolescent
environmental factors
Epigenomics
evidence

Cite this

Verhagen, M. ; Vink, J. M. ; Verweij, K. J. H. ; Lodder, Gerine ; Goossens, Luc ; Verschueren, Karine ; Colpin, H. ; Van Leeuwen, K. ; Van den Noortgate, Wim ; Claes, S. ; Bijttebier, Patricia ; Van Assche, E. / A SNP, gene and polygenic risk score approach of oxytocin-vasopressin genes in adolescents’ loneliness. In: Journal of Research on Adolescence. 2019.
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title = "A SNP, gene and polygenic risk score approach of oxytocin-vasopressin genes in adolescents’ loneliness",
abstract = "Not much is known regarding underlying biological pathways to adolescents’ loneliness. Insight in underlying molecular mechanisms could inform intervention efforts aimed at reducing loneliness. Using latent growth curve modeling, baseline levels and development of loneliness were studied in two longitudinal adolescent samples. Genes (OXTR, OXT, AVPR1A, AVPR1B) were examined using SNP‐based, gene‐based, and polygenic risk score (PRS) approaches. In both samples, SNP‐ and gene‐based tests showed involvement of the OXTR gene in development of loneliness, though, significance levels did not survive correction for multiple testing. The PRS approach provided no evidence for relations with loneliness. We recommend alternative phenotyping methods, including environmental factors, to consider epigenetic studies, and to examine possible endophenotypes in relation to adolescents’ loneliness.",
author = "M. Verhagen and Vink, {J. M.} and Verweij, {K. J. H.} and Gerine Lodder and Luc Goossens and Karine Verschueren and H. Colpin and {Van Leeuwen}, K. and {Van den Noortgate}, Wim and S. Claes and Patricia Bijttebier and {Van Assche}, E",
year = "2019",
doi = "10.1111/jora.12480",
language = "English",
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Verhagen, M, Vink, JM, Verweij, KJH, Lodder, G, Goossens, L, Verschueren, K, Colpin, H, Van Leeuwen, K, Van den Noortgate, W, Claes, S, Bijttebier, P & Van Assche, E 2019, 'A SNP, gene and polygenic risk score approach of oxytocin-vasopressin genes in adolescents’ loneliness' Journal of Research on Adolescence. https://doi.org/10.1111/jora.12480

A SNP, gene and polygenic risk score approach of oxytocin-vasopressin genes in adolescents’ loneliness. / Verhagen, M.; Vink, J. M.; Verweij, K. J. H.; Lodder, Gerine; Goossens, Luc; Verschueren, Karine; Colpin, H.; Van Leeuwen, K.; Van den Noortgate, Wim; Claes, S.; Bijttebier, Patricia; Van Assche, E.

In: Journal of Research on Adolescence, 2019.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - A SNP, gene and polygenic risk score approach of oxytocin-vasopressin genes in adolescents’ loneliness

AU - Verhagen, M.

AU - Vink, J. M.

AU - Verweij, K. J. H.

AU - Lodder, Gerine

AU - Goossens, Luc

AU - Verschueren, Karine

AU - Colpin, H.

AU - Van Leeuwen, K.

AU - Van den Noortgate, Wim

AU - Claes, S.

AU - Bijttebier, Patricia

AU - Van Assche, E

PY - 2019

Y1 - 2019

N2 - Not much is known regarding underlying biological pathways to adolescents’ loneliness. Insight in underlying molecular mechanisms could inform intervention efforts aimed at reducing loneliness. Using latent growth curve modeling, baseline levels and development of loneliness were studied in two longitudinal adolescent samples. Genes (OXTR, OXT, AVPR1A, AVPR1B) were examined using SNP‐based, gene‐based, and polygenic risk score (PRS) approaches. In both samples, SNP‐ and gene‐based tests showed involvement of the OXTR gene in development of loneliness, though, significance levels did not survive correction for multiple testing. The PRS approach provided no evidence for relations with loneliness. We recommend alternative phenotyping methods, including environmental factors, to consider epigenetic studies, and to examine possible endophenotypes in relation to adolescents’ loneliness.

AB - Not much is known regarding underlying biological pathways to adolescents’ loneliness. Insight in underlying molecular mechanisms could inform intervention efforts aimed at reducing loneliness. Using latent growth curve modeling, baseline levels and development of loneliness were studied in two longitudinal adolescent samples. Genes (OXTR, OXT, AVPR1A, AVPR1B) were examined using SNP‐based, gene‐based, and polygenic risk score (PRS) approaches. In both samples, SNP‐ and gene‐based tests showed involvement of the OXTR gene in development of loneliness, though, significance levels did not survive correction for multiple testing. The PRS approach provided no evidence for relations with loneliness. We recommend alternative phenotyping methods, including environmental factors, to consider epigenetic studies, and to examine possible endophenotypes in relation to adolescents’ loneliness.

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M3 - Article

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SN - 1050-8392

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