A social cost-benefit analysis of two One Health interventions to prevent toxoplasmosis

A.W.M. Suijkerbuijk*, E.A.B. Over, M. Opsteegh, H. Deng, P.F. van Gils, A.A. Bonačić Marinović,, M. Lambooij, J.J. Polder, T.L. Feenstra, J.W.B. van der Giessen, G.A. de Wit, M-J, J. Mangen

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

In the Netherlands, toxoplasmosis ranks second in disease burden among foodborne pathogens with an estimated health loss of 1,900 Disability Adjusted Life Years and a cost-of-illness estimated at €45 million annually. Therefore, effective and preferably cost-effective preventive interventions are warranted. Freezing meat intended for raw or undercooked consumption and improving biosecurity in pig farms are promising interventions to prevent Toxoplasma gondii infections in humans. Putting these interventions into practice would expectedly reduce the number of infections; however, the net benefits for society are unknown. Stakeholders bearing the costs for these interventions will not necessary coincide with the ones having the benefits. We performed a Social Cost-Benefit Analysis to evaluate the net value of two potential interventions for the Dutch society. We assessed the costs and benefits of the two interventions and compared them with the current practice of education, especially during pregnancy. A ‘minimum scenario’ and a ‘maximum scenario’ was assumed, using input parameters with least benefits to society and input parameters with most benefits to society, respectively. For both interventions, we performed different scenario analyses. The freezing meat intervention was far more effective than the biosecurity intervention. Despite high freezing costs, freezing two meat products: steak tartare and mutton leg yielded net social benefits in both the minimum and maximum scenario, ranging from €10.6 million to €31 million for steak tartare and €0.6 million to €1.5 million for mutton leg. The biosecurity intervention would result in net costs in all scenarios ranging from €1 million to €2.5 million, due to high intervention costs and limited benefits. From a public health perspective (i.e. reducing the burden of toxoplasmosis) and the societal perspective (i.e. a net benefit for the Dutch society) freezing steak tartare and leg of mutton is to be considered.
Original languageEnglish
Article numbere0216615
Number of pages16
JournalPLoS ONE
Volume14
Issue number5
DOIs
Publication statusPublished - 2019

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Cost benefit analysis
Freezing
Cost-Benefit Analysis
Health
Leg
Meats
Costs
Meat Products
Cost of Illness
Quality-Adjusted Life Years
Bearings (structural)
Netherlands
Public health
Pathogens
Global Health
Farms
Education

Keywords

  • BEEF
  • CONGENITAL TOXOPLASMOSIS
  • DALYS
  • DISEASE BURDEN
  • FROZEN STORAGE
  • GONDII
  • INFECTION
  • MEAT
  • PATHOGENS

Cite this

Suijkerbuijk, A. W. M., Over, E. A. B., Opsteegh, M., Deng, H., van Gils, P. F., Bonačić Marinović, A. A., ... Mangen, M-J. J. (2019). A social cost-benefit analysis of two One Health interventions to prevent toxoplasmosis. PLoS ONE, 14(5), [e0216615]. https://doi.org/10.1371/journal.pone.0216615
Suijkerbuijk, A.W.M. ; Over, E.A.B. ; Opsteegh, M. ; Deng, H. ; van Gils, P.F. ; Bonačić Marinović, A.A. ; Lambooij, M. ; Polder, J.J. ; Feenstra, T.L. ; van der Giessen, J.W.B. ; de Wit, G.A. ; Mangen, M-J, J. / A social cost-benefit analysis of two One Health interventions to prevent toxoplasmosis. In: PLoS ONE. 2019 ; Vol. 14, No. 5.
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abstract = "In the Netherlands, toxoplasmosis ranks second in disease burden among foodborne pathogens with an estimated health loss of 1,900 Disability Adjusted Life Years and a cost-of-illness estimated at €45 million annually. Therefore, effective and preferably cost-effective preventive interventions are warranted. Freezing meat intended for raw or undercooked consumption and improving biosecurity in pig farms are promising interventions to prevent Toxoplasma gondii infections in humans. Putting these interventions into practice would expectedly reduce the number of infections; however, the net benefits for society are unknown. Stakeholders bearing the costs for these interventions will not necessary coincide with the ones having the benefits. We performed a Social Cost-Benefit Analysis to evaluate the net value of two potential interventions for the Dutch society. We assessed the costs and benefits of the two interventions and compared them with the current practice of education, especially during pregnancy. A ‘minimum scenario’ and a ‘maximum scenario’ was assumed, using input parameters with least benefits to society and input parameters with most benefits to society, respectively. For both interventions, we performed different scenario analyses. The freezing meat intervention was far more effective than the biosecurity intervention. Despite high freezing costs, freezing two meat products: steak tartare and mutton leg yielded net social benefits in both the minimum and maximum scenario, ranging from €10.6 million to €31 million for steak tartare and €0.6 million to €1.5 million for mutton leg. The biosecurity intervention would result in net costs in all scenarios ranging from €1 million to €2.5 million, due to high intervention costs and limited benefits. From a public health perspective (i.e. reducing the burden of toxoplasmosis) and the societal perspective (i.e. a net benefit for the Dutch society) freezing steak tartare and leg of mutton is to be considered.",
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author = "A.W.M. Suijkerbuijk and E.A.B. Over and M. Opsteegh and H. Deng and {van Gils}, P.F. and {Bonačić Marinović,}, A.A. and M. Lambooij and J.J. Polder and T.L. Feenstra and {van der Giessen}, J.W.B. and {de Wit}, G.A. and Mangen, {M-J, J.}",
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Suijkerbuijk, AWM, Over, EAB, Opsteegh, M, Deng, H, van Gils, PF, Bonačić Marinović, AA, Lambooij, M, Polder, JJ, Feenstra, TL, van der Giessen, JWB, de Wit, GA & Mangen, M-JJ 2019, 'A social cost-benefit analysis of two One Health interventions to prevent toxoplasmosis', PLoS ONE, vol. 14, no. 5, e0216615. https://doi.org/10.1371/journal.pone.0216615

A social cost-benefit analysis of two One Health interventions to prevent toxoplasmosis. / Suijkerbuijk, A.W.M.; Over, E.A.B.; Opsteegh, M.; Deng, H.; van Gils, P.F.; Bonačić Marinović, A.A.; Lambooij, M.; Polder, J.J.; Feenstra, T.L.; van der Giessen, J.W.B.; de Wit, G.A.; Mangen, M-J, J.

In: PLoS ONE, Vol. 14, No. 5, e0216615, 2019.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - A social cost-benefit analysis of two One Health interventions to prevent toxoplasmosis

AU - Suijkerbuijk, A.W.M.

AU - Over, E.A.B.

AU - Opsteegh, M.

AU - Deng, H.

AU - van Gils, P.F.

AU - Bonačić Marinović,, A.A.

AU - Lambooij, M.

AU - Polder, J.J.

AU - Feenstra, T.L.

AU - van der Giessen, J.W.B.

AU - de Wit, G.A.

AU - Mangen, M-J, J.

PY - 2019

Y1 - 2019

N2 - In the Netherlands, toxoplasmosis ranks second in disease burden among foodborne pathogens with an estimated health loss of 1,900 Disability Adjusted Life Years and a cost-of-illness estimated at €45 million annually. Therefore, effective and preferably cost-effective preventive interventions are warranted. Freezing meat intended for raw or undercooked consumption and improving biosecurity in pig farms are promising interventions to prevent Toxoplasma gondii infections in humans. Putting these interventions into practice would expectedly reduce the number of infections; however, the net benefits for society are unknown. Stakeholders bearing the costs for these interventions will not necessary coincide with the ones having the benefits. We performed a Social Cost-Benefit Analysis to evaluate the net value of two potential interventions for the Dutch society. We assessed the costs and benefits of the two interventions and compared them with the current practice of education, especially during pregnancy. A ‘minimum scenario’ and a ‘maximum scenario’ was assumed, using input parameters with least benefits to society and input parameters with most benefits to society, respectively. For both interventions, we performed different scenario analyses. The freezing meat intervention was far more effective than the biosecurity intervention. Despite high freezing costs, freezing two meat products: steak tartare and mutton leg yielded net social benefits in both the minimum and maximum scenario, ranging from €10.6 million to €31 million for steak tartare and €0.6 million to €1.5 million for mutton leg. The biosecurity intervention would result in net costs in all scenarios ranging from €1 million to €2.5 million, due to high intervention costs and limited benefits. From a public health perspective (i.e. reducing the burden of toxoplasmosis) and the societal perspective (i.e. a net benefit for the Dutch society) freezing steak tartare and leg of mutton is to be considered.

AB - In the Netherlands, toxoplasmosis ranks second in disease burden among foodborne pathogens with an estimated health loss of 1,900 Disability Adjusted Life Years and a cost-of-illness estimated at €45 million annually. Therefore, effective and preferably cost-effective preventive interventions are warranted. Freezing meat intended for raw or undercooked consumption and improving biosecurity in pig farms are promising interventions to prevent Toxoplasma gondii infections in humans. Putting these interventions into practice would expectedly reduce the number of infections; however, the net benefits for society are unknown. Stakeholders bearing the costs for these interventions will not necessary coincide with the ones having the benefits. We performed a Social Cost-Benefit Analysis to evaluate the net value of two potential interventions for the Dutch society. We assessed the costs and benefits of the two interventions and compared them with the current practice of education, especially during pregnancy. A ‘minimum scenario’ and a ‘maximum scenario’ was assumed, using input parameters with least benefits to society and input parameters with most benefits to society, respectively. For both interventions, we performed different scenario analyses. The freezing meat intervention was far more effective than the biosecurity intervention. Despite high freezing costs, freezing two meat products: steak tartare and mutton leg yielded net social benefits in both the minimum and maximum scenario, ranging from €10.6 million to €31 million for steak tartare and €0.6 million to €1.5 million for mutton leg. The biosecurity intervention would result in net costs in all scenarios ranging from €1 million to €2.5 million, due to high intervention costs and limited benefits. From a public health perspective (i.e. reducing the burden of toxoplasmosis) and the societal perspective (i.e. a net benefit for the Dutch society) freezing steak tartare and leg of mutton is to be considered.

KW - BEEF

KW - CONGENITAL TOXOPLASMOSIS

KW - DALYS

KW - DISEASE BURDEN

KW - FROZEN STORAGE

KW - GONDII

KW - INFECTION

KW - MEAT

KW - PATHOGENS

U2 - 10.1371/journal.pone.0216615

DO - 10.1371/journal.pone.0216615

M3 - Article

VL - 14

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 5

M1 - e0216615

ER -

Suijkerbuijk AWM, Over EAB, Opsteegh M, Deng H, van Gils PF, Bonačić Marinović, AA et al. A social cost-benefit analysis of two One Health interventions to prevent toxoplasmosis. PLoS ONE. 2019;14(5). e0216615. https://doi.org/10.1371/journal.pone.0216615