A standard calculation methodology for human doubly labeled water studies

John R. Speakman; Yosuke Yamada; Hiroyuki Sagayama; Elena S.f. Berman; Philip N. Ainslie; Lene F. Andersen; Liam J. Anderson; Lenore Arab; Issaad Baddou; Kweku Bedu-addo; Ellen E. Blaak; Stephane Blanc; Alberto G. Bonomi; Carlijn V.c. Bouten; Pascal Bovet; Maciej S. Buchowski; Nancy F. Butte; Stefan G.j.a. Camps; Graeme L. Close; Jamie A. Cooper; Seth A. Creasy; Sai Krupa Das; Richard Cooper; Lara R. Dugas; Cara B. Ebbeling; Ulf Ekelund; Sonja Entringer; Terrence Forrester; Barry W. Fudge; Annelies H. Goris; Michael Gurven; Catherine Hambly; Asmaa El Hamdouchi; Marije B. Hoos; Sumei Hu; Noorjehan Joonas; Annemiek M. Joosen; Peter Katzmarzyk; Kitty P. Kempen; Misaka Kimura; William E. Kraus; Robert F. Kushner; Estelle V. Lambert; William R. Leonard; Nader Lessan; David S. Ludwig; Corby K. Martin; Anine C. Medin; Erwin P. Meijer; James C. Morehen; James P. Morton; Marian L. Neuhouser; Theresa A. Nicklas; Robert M. Ojiambo; Kirsi H. Pietiläinen; Yannis P. Pitsiladis; Jacob Plange-rhule; Guy Plasqui; Ross L. Prentice; Roberto A. Rabinovich; Susan B. Racette; David A. Raichlen; Eric Ravussin; Rebecca M. Reynolds; Susan B. Roberts; Albertine J. Schuit; Anders M. Sjödin; Eric Stice; Samuel S. Urlacher; Giulio Valenti; Ludo M. Van Etten; Edgar A. Van Mil; Jonathan C.k. Wells; George Wilson; Brian M. Wood; Jack Yanovski; Tsukasa Yoshida; Xueying Zhang; Alexia J. Murphy-alford; Cornelia U. Loechl; Edward L. Melanson; Amy H. Luke; Herman Pontzer; Jennifer Rood; Dale A. Schoeller; Klaas R. Westerterp; William W. Wong

doi:10.1016/j.xcrm.2021.100203

A standard calculation methodology for human doubly labeled water studies

John R. Speakman, Yosuke Yamada, Hiroyuki Sagayama, Elena S.f. Berman, Philip N. Ainslie, Lene F. Andersen, Liam J. Anderson, Lenore Arab, Issaad Baddou, Kweku Bedu-addo, Ellen E. Blaak, Stephane Blanc, Alberto G. Bonomi, Carlijn V.c. Bouten, Pascal Bovet, Maciej S. Buchowski, Nancy F. Butte, Stefan G.j.a. Camps, Graeme L. Close, Jamie A. CooperSeth A. Creasy, Sai Krupa Das, Richard Cooper, Lara R. Dugas, Cara B. Ebbeling, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Annelies H. Goris, Michael Gurven, Catherine Hambly, Asmaa El Hamdouchi, Marije B. Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M. Joosen, Peter Katzmarzyk, Kitty P. Kempen, Misaka Kimura, William E. Kraus, Robert F. Kushner, Estelle V. Lambert, William R. Leonard, Nader Lessan, David S. Ludwig, Corby K. Martin, Anine C. Medin, Erwin P. Meijer, James C. Morehen, James P. Morton, Marian L. Neuhouser, Theresa A. Nicklas, Robert M. Ojiambo, Kirsi H. Pietiläinen, Yannis P. Pitsiladis, Jacob Plange-rhule, Guy Plasqui, Ross L. Prentice, Roberto A. Rabinovich, Susan B. Racette, David A. Raichlen, Eric Ravussin, Rebecca M. Reynolds, Susan B. Roberts, Albertine J. Schuit, Anders M. Sjödin, Eric Stice, Samuel S. Urlacher, Giulio Valenti, Ludo M. Van Etten, Edgar A. Van Mil, Jonathan C.k. Wells, George Wilson, Brian M. Wood, Jack Yanovski, Tsukasa Yoshida, Xueying Zhang, Alexia J. Murphy-alford, Cornelia U. Loechl, Edward L. Melanson, Amy H. Luke, Herman Pontzer, Jennifer Rood, Dale A. Schoeller, Klaas R. Westerterp, William W. Wong

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Abstract

The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO2 is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (<10 kg). Using data for 1,021 babies and infants, we show that the DSR varies non-linearly with body mass between 0 and 10 kg. Using this relationship to predict DSR from weight provides an equation for rCO2 over this size range that agrees well with indirect calorimetry (average difference 0.64%; SD = 12.2%). We propose adoption of these equations in future studies.

Original language	English
Article number	100203
Number of pages	13
Journal	Cell Reports Medicine
Volume	2
Issue number	2
DOIs	https://doi.org/10.1016/j.xcrm.2021.100203
Publication status	Published - 2021

Keywords

(H2O)-H-2-O-18 METHOD
BODY-WATER
CARBON-DIOXIDE PRODUCTION
CO2 PRODUCTION
DILUTION SPACE RATIO
ENERGY-EXPENDITURE
H-2
INDIRECT CALORIMETRY
O-18
VALIDATION

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Speakman, J. R., Yamada, Y., Sagayama, H., Berman, E. S. F., Ainslie, P. N., Andersen, L. F., Anderson, L. J., Arab, L., Baddou, I., Bedu-addo, K., Blaak, E. E., Blanc, S., Bonomi, A. G., Bouten, C. V. C., Bovet, P., Buchowski, M. S., Butte, N. F., Camps, S. G. J. A., Close, G. L., ... Wong, W. W. (2021). A standard calculation methodology for human doubly labeled water studies. Cell Reports Medicine, 2(2), Article 100203. https://doi.org/10.1016/j.xcrm.2021.100203

@article{54178aa3e01e41de80761953e69b6778,

title = "A standard calculation methodology for human doubly labeled water studies",

abstract = "The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO2 is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (<10 kg). Using data for 1,021 babies and infants, we show that the DSR varies non-linearly with body mass between 0 and 10 kg. Using this relationship to predict DSR from weight provides an equation for rCO2 over this size range that agrees well with indirect calorimetry (average difference 0.64%; SD = 12.2%). We propose adoption of these equations in future studies.",

keywords = "(H2O)-H-2-O-18 METHOD, BODY-WATER, CARBON-DIOXIDE PRODUCTION, CO2 PRODUCTION, DILUTION SPACE RATIO, ENERGY-EXPENDITURE, H-2, INDIRECT CALORIMETRY, O-18, VALIDATION",

author = "Speakman, {John R.} and Yosuke Yamada and Hiroyuki Sagayama and Berman, {Elena S.f.} and Ainslie, {Philip N.} and Andersen, {Lene F.} and Anderson, {Liam J.} and Lenore Arab and Issaad Baddou and Kweku Bedu-addo and Blaak, {Ellen E.} and Stephane Blanc and Bonomi, {Alberto G.} and Bouten, {Carlijn V.c.} and Pascal Bovet and Buchowski, {Maciej S.} and Butte, {Nancy F.} and Camps, {Stefan G.j.a.} and Close, {Graeme L.} and Cooper, {Jamie A.} and Creasy, {Seth A.} and Das, {Sai Krupa} and Richard Cooper and Dugas, {Lara R.} and Ebbeling, {Cara B.} and Ulf Ekelund and Sonja Entringer and Terrence Forrester and Fudge, {Barry W.} and Goris, {Annelies H.} and Michael Gurven and Catherine Hambly and {El Hamdouchi}, Asmaa and Hoos, {Marije B.} and Sumei Hu and Noorjehan Joonas and Joosen, {Annemiek M.} and Peter Katzmarzyk and Kempen, {Kitty P.} and Misaka Kimura and Kraus, {William E.} and Kushner, {Robert F.} and Lambert, {Estelle V.} and Leonard, {William R.} and Nader Lessan and Ludwig, {David S.} and Martin, {Corby K.} and Medin, {Anine C.} and Meijer, {Erwin P.} and Morehen, {James C.} and Morton, {James P.} and Neuhouser, {Marian L.} and Nicklas, {Theresa A.} and Ojiambo, {Robert M.} and Pietil{\"a}inen, {Kirsi H.} and Pitsiladis, {Yannis P.} and Jacob Plange-rhule and Guy Plasqui and Prentice, {Ross L.} and Rabinovich, {Roberto A.} and Racette, {Susan B.} and Raichlen, {David A.} and Eric Ravussin and Reynolds, {Rebecca M.} and Roberts, {Susan B.} and Schuit, {Albertine J.} and Sj{\"o}din, {Anders M.} and Eric Stice and Urlacher, {Samuel S.} and Giulio Valenti and {Van Etten}, {Ludo M.} and {Van Mil}, {Edgar A.} and Wells, {Jonathan C.k.} and George Wilson and Wood, {Brian M.} and Jack Yanovski and Tsukasa Yoshida and Xueying Zhang and Murphy-alford, {Alexia J.} and Loechl, {Cornelia U.} and Melanson, {Edward L.} and Luke, {Amy H.} and Herman Pontzer and Jennifer Rood and Schoeller, {Dale A.} and Westerterp, {Klaas R.} and Wong, {William W.}",

note = "Funding Information: The DLW database, which can be found at https://www.dlwdatabase.org/ , is generously supported by the IAEA (Vienna, Austria) , Taiyo Nippon Sanso , and SERCON . We are grateful to these companies for their support and especially to Takashi Oono for his tremendous efforts at fund raising on our behalf. The authors also gratefully acknowledge funding from the US National Science Foundation ( BCS-1824466 ) awarded to Herman Pontzer. The funders played no role in the content of this manuscript. Publisher Copyright: {\textcopyright} 2021 The Authors Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

doi = "10.1016/j.xcrm.2021.100203",

language = "English",

volume = "2",

journal = "Cell Reports Medicine",

issn = "2666-3791",

publisher = "Cell Press",

number = "2",

}

Speakman, JR, Yamada, Y, Sagayama, H, Berman, ESF, Ainslie, PN, Andersen, LF, Anderson, LJ, Arab, L, Baddou, I, Bedu-addo, K, Blaak, EE, Blanc, S, Bonomi, AG, Bouten, CVC, Bovet, P, Buchowski, MS, Butte, NF, Camps, SGJA, Close, GL, Cooper, JA, Creasy, SA, Das, SK, Cooper, R, Dugas, LR, Ebbeling, CB, Ekelund, U, Entringer, S, Forrester, T, Fudge, BW, Goris, AH, Gurven, M, Hambly, C, El Hamdouchi, A, Hoos, MB, Hu, S, Joonas, N, Joosen, AM, Katzmarzyk, P, Kempen, KP, Kimura, M, Kraus, WE, Kushner, RF, Lambert, EV, Leonard, WR, Lessan, N, Ludwig, DS, Martin, CK, Medin, AC, Meijer, EP, Morehen, JC, Morton, JP, Neuhouser, ML, Nicklas, TA, Ojiambo, RM, Pietiläinen, KH, Pitsiladis, YP, Plange-rhule, J, Plasqui, G, Prentice, RL, Rabinovich, RA, Racette, SB, Raichlen, DA, Ravussin, E, Reynolds, RM, Roberts, SB, Schuit, AJ, Sjödin, AM, Stice, E, Urlacher, SS, Valenti, G, Van Etten, LM, Van Mil, EA, Wells, JCK, Wilson, G, Wood, BM, Yanovski, J, Yoshida, T, Zhang, X, Murphy-alford, AJ, Loechl, CU, Melanson, EL, Luke, AH, Pontzer, H, Rood, J, Schoeller, DA, Westerterp, KR & Wong, WW 2021, 'A standard calculation methodology for human doubly labeled water studies', Cell Reports Medicine, vol. 2, no. 2, 100203. https://doi.org/10.1016/j.xcrm.2021.100203

TY - JOUR

T1 - A standard calculation methodology for human doubly labeled water studies

AU - Speakman, John R.

AU - Yamada, Yosuke

AU - Sagayama, Hiroyuki

AU - Berman, Elena S.f.

AU - Ainslie, Philip N.

AU - Andersen, Lene F.

AU - Anderson, Liam J.

AU - Arab, Lenore

AU - Baddou, Issaad

AU - Bedu-addo, Kweku

AU - Blaak, Ellen E.

AU - Blanc, Stephane

AU - Bonomi, Alberto G.

AU - Bouten, Carlijn V.c.

AU - Bovet, Pascal

AU - Buchowski, Maciej S.

AU - Butte, Nancy F.

AU - Camps, Stefan G.j.a.

AU - Close, Graeme L.

AU - Cooper, Jamie A.

AU - Creasy, Seth A.

AU - Das, Sai Krupa

AU - Cooper, Richard

AU - Dugas, Lara R.

AU - Ebbeling, Cara B.

AU - Ekelund, Ulf

AU - Entringer, Sonja

AU - Forrester, Terrence

AU - Fudge, Barry W.

AU - Goris, Annelies H.

AU - Gurven, Michael

AU - Hambly, Catherine

AU - El Hamdouchi, Asmaa

AU - Hoos, Marije B.

AU - Hu, Sumei

AU - Joonas, Noorjehan

AU - Joosen, Annemiek M.

AU - Katzmarzyk, Peter

AU - Kempen, Kitty P.

AU - Kimura, Misaka

AU - Kraus, William E.

AU - Kushner, Robert F.

AU - Lambert, Estelle V.

AU - Leonard, William R.

AU - Lessan, Nader

AU - Ludwig, David S.

AU - Martin, Corby K.

AU - Medin, Anine C.

AU - Meijer, Erwin P.

AU - Morehen, James C.

AU - Morton, James P.

AU - Neuhouser, Marian L.

AU - Nicklas, Theresa A.

AU - Ojiambo, Robert M.

AU - Pietiläinen, Kirsi H.

AU - Pitsiladis, Yannis P.

AU - Plange-rhule, Jacob

AU - Plasqui, Guy

AU - Prentice, Ross L.

AU - Rabinovich, Roberto A.

AU - Racette, Susan B.

AU - Raichlen, David A.

AU - Ravussin, Eric

AU - Reynolds, Rebecca M.

AU - Roberts, Susan B.

AU - Schuit, Albertine J.

AU - Sjödin, Anders M.

AU - Stice, Eric

AU - Urlacher, Samuel S.

AU - Valenti, Giulio

AU - Van Etten, Ludo M.

AU - Van Mil, Edgar A.

AU - Wells, Jonathan C.k.

AU - Wilson, George

AU - Wood, Brian M.

AU - Yanovski, Jack

AU - Yoshida, Tsukasa

AU - Zhang, Xueying

AU - Murphy-alford, Alexia J.

AU - Loechl, Cornelia U.

AU - Melanson, Edward L.

AU - Luke, Amy H.

AU - Pontzer, Herman

AU - Rood, Jennifer

AU - Schoeller, Dale A.

AU - Westerterp, Klaas R.

AU - Wong, William W.

N1 - Funding Information: The DLW database, which can be found at https://www.dlwdatabase.org/ , is generously supported by the IAEA (Vienna, Austria) , Taiyo Nippon Sanso , and SERCON . We are grateful to these companies for their support and especially to Takashi Oono for his tremendous efforts at fund raising on our behalf. The authors also gratefully acknowledge funding from the US National Science Foundation ( BCS-1824466 ) awarded to Herman Pontzer. The funders played no role in the content of this manuscript. Publisher Copyright: © 2021 The Authors Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021

Y1 - 2021

N2 - The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO2 is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (<10 kg). Using data for 1,021 babies and infants, we show that the DSR varies non-linearly with body mass between 0 and 10 kg. Using this relationship to predict DSR from weight provides an equation for rCO2 over this size range that agrees well with indirect calorimetry (average difference 0.64%; SD = 12.2%). We propose adoption of these equations in future studies.

AB - The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO2 is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (<10 kg). Using data for 1,021 babies and infants, we show that the DSR varies non-linearly with body mass between 0 and 10 kg. Using this relationship to predict DSR from weight provides an equation for rCO2 over this size range that agrees well with indirect calorimetry (average difference 0.64%; SD = 12.2%). We propose adoption of these equations in future studies.

KW - (H2O)-H-2-O-18 METHOD

KW - BODY-WATER

KW - CARBON-DIOXIDE PRODUCTION

KW - CO2 PRODUCTION

KW - DILUTION SPACE RATIO

KW - ENERGY-EXPENDITURE

KW - H-2

KW - INDIRECT CALORIMETRY

KW - O-18

KW - VALIDATION

UR - http://www.scopus.com/inward/record.url?scp=85100971338&partnerID=8YFLogxK

U2 - 10.1016/j.xcrm.2021.100203

DO - 10.1016/j.xcrm.2021.100203

M3 - Article

SN - 2666-3791

VL - 2

JO - Cell Reports Medicine

JF - Cell Reports Medicine

IS - 2

M1 - 100203

ER -

A standard calculation methodology for human doubly labeled water studies

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