E-government projects have a breadth of impact that extends far beyond their respective context. However, current e-Government methodologies and models used are only tailored to specific requirements. Despite the use of interoperability in e-government, there has been a paucity of literature on adapting e-government frameworks in the healthcare context and in e-health in particular. Aiming to fill this gap, this chapter justifies why interoperability frameworks currently used in e-government may be useful in e-health. Therefore, this study attempts to address the issues faced by surveying the models consisting of effective practices in e-Government IT integration management, as well as IT support. The overall aim of this chapter is to conduct a critical analysis of well-established e-Government models and frameworks. Understanding e-Government integration project management will ultimately help in the development of an effective practice model, which will improve e-Government implementation.