Accelerating research on biological aging and mental health: Current challenges and future directions

L.K.M. Han, J.E. Verhoeven, A.R. Tyrka, B.W.J.H. Penninx, O.M. Wolkowitz, K.N.T. Mansson, D. Lindqvist, M.P.M. Boks, D. Révész, S.H. Mellon, M. Picard*

*Corresponding author for this work

Research output: Contribution to journalReview articleScientificpeer-review

Abstract

Aging is associated with complex biological changes that can be accelerated, slowed, or even temporarily reversed by biological and non-biological factors. This article focuses on the link between biological aging, psychological stressors, and mental illness. Rather than comprehensively reviewing this rapidly expanding field, we highlight challenges in this area of research and propose potential strategies to accelerate progress in this field. This effort requires the interaction of scientists across disciplines - including biology, psychiatry, psychology, and epidemiology; and across levels of analysis that emphasize different outcome measures - functional capacity, physiological, cellular, and molecular. Dialogues across disciplines and levels of analysis naturally lead to new opportunities for discovery but also to stimulating challenges. Some important challenges consist of 1) establishing the best objective and predictive biological age indicators or combinations of indicators, 2) identifying the basis for inter-individual differences in the rate of biological aging, and 3) examining to what extent interventions can delay, halt or temporarily reverse aging trajectories. Discovering how psychological states influence biological aging, and vice versa, has the potential to create novel and exciting opportunities for healthcare and possibly yield insights into the fundamental mechanisms that drive human aging
Original languageEnglish
Pages (from-to)293-311
JournalPsychoneuroendocrinology
Volume106
DOIs
Publication statusPublished - 2019

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Mental Health
Individuality
Delivery of Health Care

Keywords

  • BLOOD-CELLS
  • BRAIN AGE
  • Biological age
  • Brain
  • DNA COPY NUMBER
  • DNA methylation
  • LEUKOCYTE TELOMERE LENGTH
  • LIFE-SPAN
  • MITOCHONDRIAL-DNA
  • Mitochondria
  • PERIPHERAL-BLOOD
  • POSTTRAUMATIC-STRESS-DISORDER
  • PSYCHOLOGICAL STRESS
  • Psychopathology
  • QUANTITATIVE ASSESSMENT
  • Telomere length

Cite this

Han, L. K. M., Verhoeven, J. E., Tyrka, A. R., Penninx, B. W. J. H., Wolkowitz, O. M., Mansson, K. N. T., ... Picard, M. (2019). Accelerating research on biological aging and mental health: Current challenges and future directions. Psychoneuroendocrinology, 106, 293-311. https://doi.org/10.1016/j.psyneuen.2019.04.004
Han, L.K.M. ; Verhoeven, J.E. ; Tyrka, A.R. ; Penninx, B.W.J.H. ; Wolkowitz, O.M. ; Mansson, K.N.T. ; Lindqvist, D. ; Boks, M.P.M. ; Révész, D. ; Mellon, S.H. ; Picard, M. / Accelerating research on biological aging and mental health : Current challenges and future directions. In: Psychoneuroendocrinology. 2019 ; Vol. 106. pp. 293-311.
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Han, LKM, Verhoeven, JE, Tyrka, AR, Penninx, BWJH, Wolkowitz, OM, Mansson, KNT, Lindqvist, D, Boks, MPM, Révész, D, Mellon, SH & Picard, M 2019, 'Accelerating research on biological aging and mental health: Current challenges and future directions', Psychoneuroendocrinology, vol. 106, pp. 293-311. https://doi.org/10.1016/j.psyneuen.2019.04.004

Accelerating research on biological aging and mental health : Current challenges and future directions. / Han, L.K.M.; Verhoeven, J.E.; Tyrka, A.R.; Penninx, B.W.J.H.; Wolkowitz, O.M.; Mansson, K.N.T.; Lindqvist, D.; Boks, M.P.M.; Révész, D.; Mellon, S.H.; Picard, M.

In: Psychoneuroendocrinology, Vol. 106, 2019, p. 293-311.

Research output: Contribution to journalReview articleScientificpeer-review

TY - JOUR

T1 - Accelerating research on biological aging and mental health

T2 - Current challenges and future directions

AU - Han, L.K.M.

AU - Verhoeven, J.E.

AU - Tyrka, A.R.

AU - Penninx, B.W.J.H.

AU - Wolkowitz, O.M.

AU - Mansson, K.N.T.

AU - Lindqvist, D.

AU - Boks, M.P.M.

AU - Révész, D.

AU - Mellon, S.H.

AU - Picard, M.

PY - 2019

Y1 - 2019

N2 - Aging is associated with complex biological changes that can be accelerated, slowed, or even temporarily reversed by biological and non-biological factors. This article focuses on the link between biological aging, psychological stressors, and mental illness. Rather than comprehensively reviewing this rapidly expanding field, we highlight challenges in this area of research and propose potential strategies to accelerate progress in this field. This effort requires the interaction of scientists across disciplines - including biology, psychiatry, psychology, and epidemiology; and across levels of analysis that emphasize different outcome measures - functional capacity, physiological, cellular, and molecular. Dialogues across disciplines and levels of analysis naturally lead to new opportunities for discovery but also to stimulating challenges. Some important challenges consist of 1) establishing the best objective and predictive biological age indicators or combinations of indicators, 2) identifying the basis for inter-individual differences in the rate of biological aging, and 3) examining to what extent interventions can delay, halt or temporarily reverse aging trajectories. Discovering how psychological states influence biological aging, and vice versa, has the potential to create novel and exciting opportunities for healthcare and possibly yield insights into the fundamental mechanisms that drive human aging

AB - Aging is associated with complex biological changes that can be accelerated, slowed, or even temporarily reversed by biological and non-biological factors. This article focuses on the link between biological aging, psychological stressors, and mental illness. Rather than comprehensively reviewing this rapidly expanding field, we highlight challenges in this area of research and propose potential strategies to accelerate progress in this field. This effort requires the interaction of scientists across disciplines - including biology, psychiatry, psychology, and epidemiology; and across levels of analysis that emphasize different outcome measures - functional capacity, physiological, cellular, and molecular. Dialogues across disciplines and levels of analysis naturally lead to new opportunities for discovery but also to stimulating challenges. Some important challenges consist of 1) establishing the best objective and predictive biological age indicators or combinations of indicators, 2) identifying the basis for inter-individual differences in the rate of biological aging, and 3) examining to what extent interventions can delay, halt or temporarily reverse aging trajectories. Discovering how psychological states influence biological aging, and vice versa, has the potential to create novel and exciting opportunities for healthcare and possibly yield insights into the fundamental mechanisms that drive human aging

KW - BLOOD-CELLS

KW - BRAIN AGE

KW - Biological age

KW - Brain

KW - DNA COPY NUMBER

KW - DNA methylation

KW - LEUKOCYTE TELOMERE LENGTH

KW - LIFE-SPAN

KW - MITOCHONDRIAL-DNA

KW - Mitochondria

KW - PERIPHERAL-BLOOD

KW - POSTTRAUMATIC-STRESS-DISORDER

KW - PSYCHOLOGICAL STRESS

KW - Psychopathology

KW - QUANTITATIVE ASSESSMENT

KW - Telomere length

U2 - 10.1016/j.psyneuen.2019.04.004

DO - 10.1016/j.psyneuen.2019.04.004

M3 - Review article

C2 - 31154264

VL - 106

SP - 293

EP - 311

JO - Psychoneuroendocrinology

JF - Psychoneuroendocrinology

SN - 0306-4530

ER -