Acute alcohol intoxication in patients with mild traumatic brain injury

Characteristics, recovery, and outcome

Myrthe E. Scheenen, Myrthe E. de Koning, Harm J. van der Horn, C.M.A.A. Roks, Tansel Yilmaz, Joukje van der Naalt, Jacoba M. Spikman

Research output: Contribution to journalArticleScientificpeer-review

Abstract

A substantial number of patients (30% to 50%) sustains a mild traumatic brain injury (mTBI) while they are under the influence of alcohol. An acute alcohol intoxication (AAI) at the time of injury has been subject of research in severe TBI, but little is known about the relation between AAI and mTBI. This study aimed to describe the characteristics of this intoxicated subgroup and evaluate recovery and outcome in comparison to sober mTBI patients. We included 528 mTBI patients (Glasgow Coma Scale [GCS] score 13–15) admitted to two Level 1 trauma centers as part of a prospective follow-up study. We compared clinical characteristics, demographics, and injury mechanism between groups. Post-concussive complaints, mood disorders, and post-traumatic stress-related complaints were assessed at 2 weeks post-injury, and outcome at 6 months with the Glasgow Outcome Scale Extended (GOSE). Thirty-three percent of the mTBI patients were intoxicated. Results showed that the intoxicated group was younger (36 vs. 40 years; p = 0.001) and were more frequently of male gender (78% vs. 60%; p < .001). The groups also differed in injury related characteristics, with intoxicated patients more frequently sustaining falls or violence-related injuries. The intoxicated group was assessed with a lower GCS score and had a higher hospital admission rate. However, at 2 weeks post-injury, intoxicated patients reported less complaints than the non-alcohol group and showed a better recovery at 6 months (average GOSE scores 7 vs. 7.3; p = 0.030). We conclude that AAI in mTBI represents a characteristically different group, which has implications for prevention measures, as well as the course of recovery.
Original languageEnglish
Pages (from-to)339-345
JournalJournal of Neurotrauma
Volume33
Issue number4
DOIs
Publication statusPublished - 2016

Keywords

  • alcohol
  • complaints
  • mild traumatic brain injury
  • outcome
  • recovery

Cite this

Scheenen, M. E., de Koning, M. E., van der Horn, H. J., Roks, C. M. A. A., Yilmaz, T., van der Naalt, J., & Spikman, J. M. (2016). Acute alcohol intoxication in patients with mild traumatic brain injury: Characteristics, recovery, and outcome. Journal of Neurotrauma, 33(4), 339-345. https://doi.org/10.1089/neu.2015.3926
Scheenen, Myrthe E. ; de Koning, Myrthe E. ; van der Horn, Harm J. ; Roks, C.M.A.A. ; Yilmaz, Tansel ; van der Naalt, Joukje ; Spikman, Jacoba M. / Acute alcohol intoxication in patients with mild traumatic brain injury : Characteristics, recovery, and outcome. In: Journal of Neurotrauma. 2016 ; Vol. 33, No. 4. pp. 339-345.
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abstract = "A substantial number of patients (30{\%} to 50{\%}) sustains a mild traumatic brain injury (mTBI) while they are under the influence of alcohol. An acute alcohol intoxication (AAI) at the time of injury has been subject of research in severe TBI, but little is known about the relation between AAI and mTBI. This study aimed to describe the characteristics of this intoxicated subgroup and evaluate recovery and outcome in comparison to sober mTBI patients. We included 528 mTBI patients (Glasgow Coma Scale [GCS] score 13–15) admitted to two Level 1 trauma centers as part of a prospective follow-up study. We compared clinical characteristics, demographics, and injury mechanism between groups. Post-concussive complaints, mood disorders, and post-traumatic stress-related complaints were assessed at 2 weeks post-injury, and outcome at 6 months with the Glasgow Outcome Scale Extended (GOSE). Thirty-three percent of the mTBI patients were intoxicated. Results showed that the intoxicated group was younger (36 vs. 40 years; p = 0.001) and were more frequently of male gender (78{\%} vs. 60{\%}; p < .001). The groups also differed in injury related characteristics, with intoxicated patients more frequently sustaining falls or violence-related injuries. The intoxicated group was assessed with a lower GCS score and had a higher hospital admission rate. However, at 2 weeks post-injury, intoxicated patients reported less complaints than the non-alcohol group and showed a better recovery at 6 months (average GOSE scores 7 vs. 7.3; p = 0.030). We conclude that AAI in mTBI represents a characteristically different group, which has implications for prevention measures, as well as the course of recovery.",
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Scheenen, ME, de Koning, ME, van der Horn, HJ, Roks, CMAA, Yilmaz, T, van der Naalt, J & Spikman, JM 2016, 'Acute alcohol intoxication in patients with mild traumatic brain injury: Characteristics, recovery, and outcome', Journal of Neurotrauma, vol. 33, no. 4, pp. 339-345. https://doi.org/10.1089/neu.2015.3926

Acute alcohol intoxication in patients with mild traumatic brain injury : Characteristics, recovery, and outcome. / Scheenen, Myrthe E.; de Koning, Myrthe E.; van der Horn, Harm J.; Roks, C.M.A.A.; Yilmaz, Tansel; van der Naalt, Joukje; Spikman, Jacoba M.

In: Journal of Neurotrauma, Vol. 33, No. 4, 2016, p. 339-345.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Acute alcohol intoxication in patients with mild traumatic brain injury

T2 - Characteristics, recovery, and outcome

AU - Scheenen, Myrthe E.

AU - de Koning, Myrthe E.

AU - van der Horn, Harm J.

AU - Roks, C.M.A.A.

AU - Yilmaz, Tansel

AU - van der Naalt, Joukje

AU - Spikman, Jacoba M.

PY - 2016

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N2 - A substantial number of patients (30% to 50%) sustains a mild traumatic brain injury (mTBI) while they are under the influence of alcohol. An acute alcohol intoxication (AAI) at the time of injury has been subject of research in severe TBI, but little is known about the relation between AAI and mTBI. This study aimed to describe the characteristics of this intoxicated subgroup and evaluate recovery and outcome in comparison to sober mTBI patients. We included 528 mTBI patients (Glasgow Coma Scale [GCS] score 13–15) admitted to two Level 1 trauma centers as part of a prospective follow-up study. We compared clinical characteristics, demographics, and injury mechanism between groups. Post-concussive complaints, mood disorders, and post-traumatic stress-related complaints were assessed at 2 weeks post-injury, and outcome at 6 months with the Glasgow Outcome Scale Extended (GOSE). Thirty-three percent of the mTBI patients were intoxicated. Results showed that the intoxicated group was younger (36 vs. 40 years; p = 0.001) and were more frequently of male gender (78% vs. 60%; p < .001). The groups also differed in injury related characteristics, with intoxicated patients more frequently sustaining falls or violence-related injuries. The intoxicated group was assessed with a lower GCS score and had a higher hospital admission rate. However, at 2 weeks post-injury, intoxicated patients reported less complaints than the non-alcohol group and showed a better recovery at 6 months (average GOSE scores 7 vs. 7.3; p = 0.030). We conclude that AAI in mTBI represents a characteristically different group, which has implications for prevention measures, as well as the course of recovery.

AB - A substantial number of patients (30% to 50%) sustains a mild traumatic brain injury (mTBI) while they are under the influence of alcohol. An acute alcohol intoxication (AAI) at the time of injury has been subject of research in severe TBI, but little is known about the relation between AAI and mTBI. This study aimed to describe the characteristics of this intoxicated subgroup and evaluate recovery and outcome in comparison to sober mTBI patients. We included 528 mTBI patients (Glasgow Coma Scale [GCS] score 13–15) admitted to two Level 1 trauma centers as part of a prospective follow-up study. We compared clinical characteristics, demographics, and injury mechanism between groups. Post-concussive complaints, mood disorders, and post-traumatic stress-related complaints were assessed at 2 weeks post-injury, and outcome at 6 months with the Glasgow Outcome Scale Extended (GOSE). Thirty-three percent of the mTBI patients were intoxicated. Results showed that the intoxicated group was younger (36 vs. 40 years; p = 0.001) and were more frequently of male gender (78% vs. 60%; p < .001). The groups also differed in injury related characteristics, with intoxicated patients more frequently sustaining falls or violence-related injuries. The intoxicated group was assessed with a lower GCS score and had a higher hospital admission rate. However, at 2 weeks post-injury, intoxicated patients reported less complaints than the non-alcohol group and showed a better recovery at 6 months (average GOSE scores 7 vs. 7.3; p = 0.030). We conclude that AAI in mTBI represents a characteristically different group, which has implications for prevention measures, as well as the course of recovery.

KW - alcohol

KW - complaints

KW - mild traumatic brain injury

KW - outcome

KW - recovery

U2 - 10.1089/neu.2015.3926

DO - 10.1089/neu.2015.3926

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JO - Journal of Neurotrauma

JF - Journal of Neurotrauma

SN - 0897-7151

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