Age-related differences in health-related quality of life among thyroid cancer survivors compared with a normative sample: Results from the PROFILES registry

F. Mols, D. Schoormans, J.W.A. Smit, R.T. Netea-Maier, T.P. Links, W.T.A. Van der Graaf, O. Husson

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Background
The purpose of this study was to compare general health-related quality
of life (HR-QOL) of thyroid cancer survivors with a normative sample stratified
by age at diagnosis (adolescents and young adults 18-35 years; middle-aged adults 36-64 years; elderly 65-84 years), and to compare general HR-QOL and diseasespecific symptoms among adolescents and young adults, middle-aged adults, and elderly thyroid cancer survivors in an exploratory population-based cross-sectional study.
Methods
All patients diagnosed with thyroid cancer between 1990 and 2008, who
were registered in the Eindhoven Cancer Registry, received a survey. Our final sample included 293 thyroid cancer survivors.
Results
Compared with a normative sample, adolescents and young adult thyroid
cancer survivors showed statistically significant and clinically meaningfully worse
physical, role, cognitive, and social functioning, and more fatigue and financial problems. Adolescents and young adult thyroid cancer survivors scored statistically significant and clinically meaningfully better on physical functioning and interest in sex compared with the elderly and had less sympathetic and throat/mouth problems compared with middle-aged adults.
Conclusion
Thyroid cancer seems to have a greater impact on younger than older
thyroid cancer survivors and the lower HR-QOL in older compared to younger thyroid cancer survivors is probably caused mostly by their age and not the cancer.
Original languageEnglish
Pages (from-to)2235-2245
JournalHead & Neck
Volume40
Issue number10
DOIs
Publication statusPublished - 2019

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Survivors
Young Adult
Neoplasms
Cross-Sectional Studies

Keywords

  • EUROPEAN-ORGANIZATION
  • POPULATION
  • QLQ-C30
  • QUESTIONNAIRE
  • TRIALS
  • YOUNGER
  • adolescents and young adults
  • disease-specific symptoms
  • health-related quality of life
  • survivorship
  • thyroid cancer

Cite this

Mols, F. ; Schoormans, D. ; Smit, J.W.A. ; Netea-Maier, R.T. ; Links, T.P. ; Van der Graaf, W.T.A. ; Husson, O. / Age-related differences in health-related quality of life among thyroid cancer survivors compared with a normative sample : Results from the PROFILES registry. In: Head & Neck. 2019 ; Vol. 40, No. 10. pp. 2235-2245.
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title = "Age-related differences in health-related quality of life among thyroid cancer survivors compared with a normative sample: Results from the PROFILES registry",
abstract = "BackgroundThe purpose of this study was to compare general health-related qualityof life (HR-QOL) of thyroid cancer survivors with a normative sample stratifiedby age at diagnosis (adolescents and young adults 18-35 years; middle-aged adults 36-64 years; elderly 65-84 years), and to compare general HR-QOL and diseasespecific symptoms among adolescents and young adults, middle-aged adults, and elderly thyroid cancer survivors in an exploratory population-based cross-sectional study.MethodsAll patients diagnosed with thyroid cancer between 1990 and 2008, whowere registered in the Eindhoven Cancer Registry, received a survey. Our final sample included 293 thyroid cancer survivors.ResultsCompared with a normative sample, adolescents and young adult thyroidcancer survivors showed statistically significant and clinically meaningfully worsephysical, role, cognitive, and social functioning, and more fatigue and financial problems. Adolescents and young adult thyroid cancer survivors scored statistically significant and clinically meaningfully better on physical functioning and interest in sex compared with the elderly and had less sympathetic and throat/mouth problems compared with middle-aged adults.ConclusionThyroid cancer seems to have a greater impact on younger than olderthyroid cancer survivors and the lower HR-QOL in older compared to younger thyroid cancer survivors is probably caused mostly by their age and not the cancer.",
keywords = "EUROPEAN-ORGANIZATION, POPULATION, QLQ-C30, QUESTIONNAIRE, TRIALS, YOUNGER, adolescents and young adults, disease-specific symptoms, health-related quality of life, survivorship, thyroid cancer",
author = "F. Mols and D. Schoormans and J.W.A. Smit and R.T. Netea-Maier and T.P. Links and {Van der Graaf}, W.T.A. and O. Husson",
year = "2019",
doi = "10.1002/hed.25325",
language = "English",
volume = "40",
pages = "2235--2245",
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Age-related differences in health-related quality of life among thyroid cancer survivors compared with a normative sample : Results from the PROFILES registry. / Mols, F.; Schoormans, D.; Smit, J.W.A.; Netea-Maier, R.T.; Links, T.P.; Van der Graaf, W.T.A.; Husson, O.

In: Head & Neck, Vol. 40, No. 10, 2019, p. 2235-2245.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Age-related differences in health-related quality of life among thyroid cancer survivors compared with a normative sample

T2 - Results from the PROFILES registry

AU - Mols, F.

AU - Schoormans, D.

AU - Smit, J.W.A.

AU - Netea-Maier, R.T.

AU - Links, T.P.

AU - Van der Graaf, W.T.A.

AU - Husson, O.

PY - 2019

Y1 - 2019

N2 - BackgroundThe purpose of this study was to compare general health-related qualityof life (HR-QOL) of thyroid cancer survivors with a normative sample stratifiedby age at diagnosis (adolescents and young adults 18-35 years; middle-aged adults 36-64 years; elderly 65-84 years), and to compare general HR-QOL and diseasespecific symptoms among adolescents and young adults, middle-aged adults, and elderly thyroid cancer survivors in an exploratory population-based cross-sectional study.MethodsAll patients diagnosed with thyroid cancer between 1990 and 2008, whowere registered in the Eindhoven Cancer Registry, received a survey. Our final sample included 293 thyroid cancer survivors.ResultsCompared with a normative sample, adolescents and young adult thyroidcancer survivors showed statistically significant and clinically meaningfully worsephysical, role, cognitive, and social functioning, and more fatigue and financial problems. Adolescents and young adult thyroid cancer survivors scored statistically significant and clinically meaningfully better on physical functioning and interest in sex compared with the elderly and had less sympathetic and throat/mouth problems compared with middle-aged adults.ConclusionThyroid cancer seems to have a greater impact on younger than olderthyroid cancer survivors and the lower HR-QOL in older compared to younger thyroid cancer survivors is probably caused mostly by their age and not the cancer.

AB - BackgroundThe purpose of this study was to compare general health-related qualityof life (HR-QOL) of thyroid cancer survivors with a normative sample stratifiedby age at diagnosis (adolescents and young adults 18-35 years; middle-aged adults 36-64 years; elderly 65-84 years), and to compare general HR-QOL and diseasespecific symptoms among adolescents and young adults, middle-aged adults, and elderly thyroid cancer survivors in an exploratory population-based cross-sectional study.MethodsAll patients diagnosed with thyroid cancer between 1990 and 2008, whowere registered in the Eindhoven Cancer Registry, received a survey. Our final sample included 293 thyroid cancer survivors.ResultsCompared with a normative sample, adolescents and young adult thyroidcancer survivors showed statistically significant and clinically meaningfully worsephysical, role, cognitive, and social functioning, and more fatigue and financial problems. Adolescents and young adult thyroid cancer survivors scored statistically significant and clinically meaningfully better on physical functioning and interest in sex compared with the elderly and had less sympathetic and throat/mouth problems compared with middle-aged adults.ConclusionThyroid cancer seems to have a greater impact on younger than olderthyroid cancer survivors and the lower HR-QOL in older compared to younger thyroid cancer survivors is probably caused mostly by their age and not the cancer.

KW - EUROPEAN-ORGANIZATION

KW - POPULATION

KW - QLQ-C30

KW - QUESTIONNAIRE

KW - TRIALS

KW - YOUNGER

KW - adolescents and young adults

KW - disease-specific symptoms

KW - health-related quality of life

KW - survivorship

KW - thyroid cancer

U2 - 10.1002/hed.25325

DO - 10.1002/hed.25325

M3 - Article

VL - 40

SP - 2235

EP - 2245

JO - Head & Neck

JF - Head & Neck

SN - 1097-0347

IS - 10

ER -