Age-Related Increases in Tip-of-the-tongue are Distinct from Decreases in Remembering Names: A Functional MRI Study

Willem Huijbers, Kathryn V Papp, Molly LaPoint, Sarah E Wigman, Alex Dagley, Trey Hedden, Dorene M Rentz, Aaron P Schultz, Reisa A Sperling

    Research output: Contribution to journalArticleScientificpeer-review

    Abstract

    Tip-of-the-tongue (TOT) experiences increase with age and frequently heighten concerns about memory decline. We studied 73 clinically normal older adults participating in the Harvard Aging Brain Study. They completed a functional magnetic resonance imaging (fMRI) task that required remembering names associated with pictures of famous faces. Older age was associated with more self-reported TOT experiences and a decrease in the percentage of remembered names. However, the percentage of TOT experiences and the percentage of remembered names were not directly correlated. We mapped fMRI activity for recollection of famous names and TOT and examined activity in the hippocampal formation, retrosplenial cortex, and lateral prefrontal cortex. The hippocampal formation was similarly activated in recollection and TOT experiences. In contrast, the retrosplenial cortex was most active for recollection and lateral prefrontal cortex was most active for TOT experiences. Together, the results confirm that age-related increases in TOT experiences are not only solely the consequence of age-related decline in recollection, but also likely reflect functional alterations in the brain networks that support retrieval monitoring and cognitive control. These findings provide behavioral and neuroimaging evidence that age-related TOT experiences and memory failure are partially independent processes.

    Original languageEnglish
    Pages (from-to)4339-4349
    Number of pages11
    JournalCerebral Cortex
    Volume27
    Issue number9
    DOIs
    Publication statusPublished - 1 Sep 2017

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    Huijbers, W., Papp, K. V., LaPoint, M., Wigman, S. E., Dagley, A., Hedden, T., ... Sperling, R. A. (2017). Age-Related Increases in Tip-of-the-tongue are Distinct from Decreases in Remembering Names: A Functional MRI Study. Cerebral Cortex, 27(9), 4339-4349. https://doi.org/10.1093/cercor/bhw234
    Huijbers, Willem ; Papp, Kathryn V ; LaPoint, Molly ; Wigman, Sarah E ; Dagley, Alex ; Hedden, Trey ; Rentz, Dorene M ; Schultz, Aaron P ; Sperling, Reisa A. / Age-Related Increases in Tip-of-the-tongue are Distinct from Decreases in Remembering Names : A Functional MRI Study. In: Cerebral Cortex. 2017 ; Vol. 27, No. 9. pp. 4339-4349.
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    abstract = "Tip-of-the-tongue (TOT) experiences increase with age and frequently heighten concerns about memory decline. We studied 73 clinically normal older adults participating in the Harvard Aging Brain Study. They completed a functional magnetic resonance imaging (fMRI) task that required remembering names associated with pictures of famous faces. Older age was associated with more self-reported TOT experiences and a decrease in the percentage of remembered names. However, the percentage of TOT experiences and the percentage of remembered names were not directly correlated. We mapped fMRI activity for recollection of famous names and TOT and examined activity in the hippocampal formation, retrosplenial cortex, and lateral prefrontal cortex. The hippocampal formation was similarly activated in recollection and TOT experiences. In contrast, the retrosplenial cortex was most active for recollection and lateral prefrontal cortex was most active for TOT experiences. Together, the results confirm that age-related increases in TOT experiences are not only solely the consequence of age-related decline in recollection, but also likely reflect functional alterations in the brain networks that support retrieval monitoring and cognitive control. These findings provide behavioral and neuroimaging evidence that age-related TOT experiences and memory failure are partially independent processes.",
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    Huijbers, W, Papp, KV, LaPoint, M, Wigman, SE, Dagley, A, Hedden, T, Rentz, DM, Schultz, AP & Sperling, RA 2017, 'Age-Related Increases in Tip-of-the-tongue are Distinct from Decreases in Remembering Names: A Functional MRI Study', Cerebral Cortex, vol. 27, no. 9, pp. 4339-4349. https://doi.org/10.1093/cercor/bhw234

    Age-Related Increases in Tip-of-the-tongue are Distinct from Decreases in Remembering Names : A Functional MRI Study. / Huijbers, Willem; Papp, Kathryn V; LaPoint, Molly; Wigman, Sarah E; Dagley, Alex; Hedden, Trey; Rentz, Dorene M; Schultz, Aaron P; Sperling, Reisa A.

    In: Cerebral Cortex, Vol. 27, No. 9, 01.09.2017, p. 4339-4349.

    Research output: Contribution to journalArticleScientificpeer-review

    TY - JOUR

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    T2 - A Functional MRI Study

    AU - Huijbers, Willem

    AU - Papp, Kathryn V

    AU - LaPoint, Molly

    AU - Wigman, Sarah E

    AU - Dagley, Alex

    AU - Hedden, Trey

    AU - Rentz, Dorene M

    AU - Schultz, Aaron P

    AU - Sperling, Reisa A

    N1 - © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

    PY - 2017/9/1

    Y1 - 2017/9/1

    N2 - Tip-of-the-tongue (TOT) experiences increase with age and frequently heighten concerns about memory decline. We studied 73 clinically normal older adults participating in the Harvard Aging Brain Study. They completed a functional magnetic resonance imaging (fMRI) task that required remembering names associated with pictures of famous faces. Older age was associated with more self-reported TOT experiences and a decrease in the percentage of remembered names. However, the percentage of TOT experiences and the percentage of remembered names were not directly correlated. We mapped fMRI activity for recollection of famous names and TOT and examined activity in the hippocampal formation, retrosplenial cortex, and lateral prefrontal cortex. The hippocampal formation was similarly activated in recollection and TOT experiences. In contrast, the retrosplenial cortex was most active for recollection and lateral prefrontal cortex was most active for TOT experiences. Together, the results confirm that age-related increases in TOT experiences are not only solely the consequence of age-related decline in recollection, but also likely reflect functional alterations in the brain networks that support retrieval monitoring and cognitive control. These findings provide behavioral and neuroimaging evidence that age-related TOT experiences and memory failure are partially independent processes.

    AB - Tip-of-the-tongue (TOT) experiences increase with age and frequently heighten concerns about memory decline. We studied 73 clinically normal older adults participating in the Harvard Aging Brain Study. They completed a functional magnetic resonance imaging (fMRI) task that required remembering names associated with pictures of famous faces. Older age was associated with more self-reported TOT experiences and a decrease in the percentage of remembered names. However, the percentage of TOT experiences and the percentage of remembered names were not directly correlated. We mapped fMRI activity for recollection of famous names and TOT and examined activity in the hippocampal formation, retrosplenial cortex, and lateral prefrontal cortex. The hippocampal formation was similarly activated in recollection and TOT experiences. In contrast, the retrosplenial cortex was most active for recollection and lateral prefrontal cortex was most active for TOT experiences. Together, the results confirm that age-related increases in TOT experiences are not only solely the consequence of age-related decline in recollection, but also likely reflect functional alterations in the brain networks that support retrieval monitoring and cognitive control. These findings provide behavioral and neuroimaging evidence that age-related TOT experiences and memory failure are partially independent processes.

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    JO - Cerebral Cortex

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    SN - 1047-3211

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