An assisted structured reflection on life events and life goals in advanced cancer patients: Outcomes of a randomized controlled trial (Life InSight Application (LISA) study)

Renske Kruizinga, Michael Scherer-Rath, Johannes Bam Schilderman, Iris D Hartog, Jacoba Pm Van Der Loos, Hantie P Kotzé, Anneke M Westermann, Heinz-Josef Klümpen, Francesco Kortekaas, Cecile Grootscholten, Frans Bossink, Jolanda Schrama, Willem Van De Vrande, Natascha Awp Schrama, Willem Blokland, Filip Yfl De Vos, Annemieke Kuin, Wim G Meijer, Martijn Gh Van Oijen, Mirjam Ag Sprangers & 1 others Hanneke Wm Van Laarhoven

Research output: Contribution to journalArticleScientificpeer-review

Abstract

BACKGROUND:: Diagnosis and treatment of incurable cancer as a life-changing experience evokes difficult existential questions.

AIM:: A structured reflection could improve patients' quality of life and spiritual well-being. We developed an interview model on life events and ultimate life goals and performed a randomized controlled trial to evaluate the effect thereof on quality of life and spiritual well-being.

DESIGN:: The intervention group had two consultations with a spiritual counselor. The control group received care as usual. EORTC QLQ-C15-PAL and the FACIT-sp were administered at baseline and 2 and 4 months after baseline. Linear mixed model analysis was performed to test between-group differences over time.

PARTICIPANTS:: Adult patients with incurable cancer and a life expectancy ⩾6 months were randomized in a 1:1 ratio to the intervention or control group.

RESULTS:: A total of 153 patients from six different hospitals were included: 77 in the intervention group and 76 in the control group. Quality of life and spiritual well-being did not significantly change over time between groups. The experience of Meaning/Peace was found to significantly influence quality of life ( β = 0.52, adj. R2 = 0.26) and satisfaction with life ( β = 0.61, adj. R2 = 0.37).

CONCLUSION:: Although our newly developed interview model was well perceived by patients, we were not able to demonstrate a significant difference in quality of life and spiritual well-being between groups. Future interventions by spiritual counselors aimed at improving quality of life, and spiritual well-being should focus on the provision of sources of meaning and peace.

Original languageEnglish
Pages (from-to)221-231
Number of pages11
JournalPalliative Medicine
Volume33
Issue number2
DOIs
Publication statusPublished - Feb 2019

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Neoplasms
Interviews
Life Change Events
Life Expectancy
Linear Models
Counselors

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Kruizinga, Renske ; Scherer-Rath, Michael ; Schilderman, Johannes Bam ; Hartog, Iris D ; Van Der Loos, Jacoba Pm ; Kotzé, Hantie P ; Westermann, Anneke M ; Klümpen, Heinz-Josef ; Kortekaas, Francesco ; Grootscholten, Cecile ; Bossink, Frans ; Schrama, Jolanda ; Van De Vrande, Willem ; Schrama, Natascha Awp ; Blokland, Willem ; De Vos, Filip Yfl ; Kuin, Annemieke ; Meijer, Wim G ; Van Oijen, Martijn Gh ; Sprangers, Mirjam Ag ; Van Laarhoven, Hanneke Wm. / An assisted structured reflection on life events and life goals in advanced cancer patients : Outcomes of a randomized controlled trial (Life InSight Application (LISA) study). In: Palliative Medicine. 2019 ; Vol. 33, No. 2. pp. 221-231.
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title = "An assisted structured reflection on life events and life goals in advanced cancer patients: Outcomes of a randomized controlled trial (Life InSight Application (LISA) study)",
abstract = "BACKGROUND:: Diagnosis and treatment of incurable cancer as a life-changing experience evokes difficult existential questions.AIM:: A structured reflection could improve patients' quality of life and spiritual well-being. We developed an interview model on life events and ultimate life goals and performed a randomized controlled trial to evaluate the effect thereof on quality of life and spiritual well-being.DESIGN:: The intervention group had two consultations with a spiritual counselor. The control group received care as usual. EORTC QLQ-C15-PAL and the FACIT-sp were administered at baseline and 2 and 4 months after baseline. Linear mixed model analysis was performed to test between-group differences over time.PARTICIPANTS:: Adult patients with incurable cancer and a life expectancy ⩾6 months were randomized in a 1:1 ratio to the intervention or control group.RESULTS:: A total of 153 patients from six different hospitals were included: 77 in the intervention group and 76 in the control group. Quality of life and spiritual well-being did not significantly change over time between groups. The experience of Meaning/Peace was found to significantly influence quality of life ( β = 0.52, adj. R2 = 0.26) and satisfaction with life ( β = 0.61, adj. R2 = 0.37).CONCLUSION:: Although our newly developed interview model was well perceived by patients, we were not able to demonstrate a significant difference in quality of life and spiritual well-being between groups. Future interventions by spiritual counselors aimed at improving quality of life, and spiritual well-being should focus on the provision of sources of meaning and peace.",
author = "Renske Kruizinga and Michael Scherer-Rath and Schilderman, {Johannes Bam} and Hartog, {Iris D} and {Van Der Loos}, {Jacoba Pm} and Kotz{\'e}, {Hantie P} and Westermann, {Anneke M} and Heinz-Josef Kl{\"u}mpen and Francesco Kortekaas and Cecile Grootscholten and Frans Bossink and Jolanda Schrama and {Van De Vrande}, Willem and Schrama, {Natascha Awp} and Willem Blokland and {De Vos}, {Filip Yfl} and Annemieke Kuin and Meijer, {Wim G} and {Van Oijen}, {Martijn Gh} and Sprangers, {Mirjam Ag} and {Van Laarhoven}, {Hanneke Wm}",
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Kruizinga, R, Scherer-Rath, M, Schilderman, JB, Hartog, ID, Van Der Loos, JP, Kotzé, HP, Westermann, AM, Klümpen, H-J, Kortekaas, F, Grootscholten, C, Bossink, F, Schrama, J, Van De Vrande, W, Schrama, NA, Blokland, W, De Vos, FY, Kuin, A, Meijer, WG, Van Oijen, MG, Sprangers, MA & Van Laarhoven, HW 2019, 'An assisted structured reflection on life events and life goals in advanced cancer patients: Outcomes of a randomized controlled trial (Life InSight Application (LISA) study)' Palliative Medicine, vol. 33, no. 2, pp. 221-231. https://doi.org/10.1177/0269216318816005

An assisted structured reflection on life events and life goals in advanced cancer patients : Outcomes of a randomized controlled trial (Life InSight Application (LISA) study). / Kruizinga, Renske; Scherer-Rath, Michael; Schilderman, Johannes Bam; Hartog, Iris D; Van Der Loos, Jacoba Pm; Kotzé, Hantie P; Westermann, Anneke M; Klümpen, Heinz-Josef; Kortekaas, Francesco; Grootscholten, Cecile; Bossink, Frans; Schrama, Jolanda; Van De Vrande, Willem; Schrama, Natascha Awp; Blokland, Willem; De Vos, Filip Yfl; Kuin, Annemieke; Meijer, Wim G; Van Oijen, Martijn Gh; Sprangers, Mirjam Ag; Van Laarhoven, Hanneke Wm.

In: Palliative Medicine, Vol. 33, No. 2, 02.2019, p. 221-231.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - An assisted structured reflection on life events and life goals in advanced cancer patients

T2 - Outcomes of a randomized controlled trial (Life InSight Application (LISA) study)

AU - Kruizinga, Renske

AU - Scherer-Rath, Michael

AU - Schilderman, Johannes Bam

AU - Hartog, Iris D

AU - Van Der Loos, Jacoba Pm

AU - Kotzé, Hantie P

AU - Westermann, Anneke M

AU - Klümpen, Heinz-Josef

AU - Kortekaas, Francesco

AU - Grootscholten, Cecile

AU - Bossink, Frans

AU - Schrama, Jolanda

AU - Van De Vrande, Willem

AU - Schrama, Natascha Awp

AU - Blokland, Willem

AU - De Vos, Filip Yfl

AU - Kuin, Annemieke

AU - Meijer, Wim G

AU - Van Oijen, Martijn Gh

AU - Sprangers, Mirjam Ag

AU - Van Laarhoven, Hanneke Wm

PY - 2019/2

Y1 - 2019/2

N2 - BACKGROUND:: Diagnosis and treatment of incurable cancer as a life-changing experience evokes difficult existential questions.AIM:: A structured reflection could improve patients' quality of life and spiritual well-being. We developed an interview model on life events and ultimate life goals and performed a randomized controlled trial to evaluate the effect thereof on quality of life and spiritual well-being.DESIGN:: The intervention group had two consultations with a spiritual counselor. The control group received care as usual. EORTC QLQ-C15-PAL and the FACIT-sp were administered at baseline and 2 and 4 months after baseline. Linear mixed model analysis was performed to test between-group differences over time.PARTICIPANTS:: Adult patients with incurable cancer and a life expectancy ⩾6 months were randomized in a 1:1 ratio to the intervention or control group.RESULTS:: A total of 153 patients from six different hospitals were included: 77 in the intervention group and 76 in the control group. Quality of life and spiritual well-being did not significantly change over time between groups. The experience of Meaning/Peace was found to significantly influence quality of life ( β = 0.52, adj. R2 = 0.26) and satisfaction with life ( β = 0.61, adj. R2 = 0.37).CONCLUSION:: Although our newly developed interview model was well perceived by patients, we were not able to demonstrate a significant difference in quality of life and spiritual well-being between groups. Future interventions by spiritual counselors aimed at improving quality of life, and spiritual well-being should focus on the provision of sources of meaning and peace.

AB - BACKGROUND:: Diagnosis and treatment of incurable cancer as a life-changing experience evokes difficult existential questions.AIM:: A structured reflection could improve patients' quality of life and spiritual well-being. We developed an interview model on life events and ultimate life goals and performed a randomized controlled trial to evaluate the effect thereof on quality of life and spiritual well-being.DESIGN:: The intervention group had two consultations with a spiritual counselor. The control group received care as usual. EORTC QLQ-C15-PAL and the FACIT-sp were administered at baseline and 2 and 4 months after baseline. Linear mixed model analysis was performed to test between-group differences over time.PARTICIPANTS:: Adult patients with incurable cancer and a life expectancy ⩾6 months were randomized in a 1:1 ratio to the intervention or control group.RESULTS:: A total of 153 patients from six different hospitals were included: 77 in the intervention group and 76 in the control group. Quality of life and spiritual well-being did not significantly change over time between groups. The experience of Meaning/Peace was found to significantly influence quality of life ( β = 0.52, adj. R2 = 0.26) and satisfaction with life ( β = 0.61, adj. R2 = 0.37).CONCLUSION:: Although our newly developed interview model was well perceived by patients, we were not able to demonstrate a significant difference in quality of life and spiritual well-being between groups. Future interventions by spiritual counselors aimed at improving quality of life, and spiritual well-being should focus on the provision of sources of meaning and peace.

U2 - 10.1177/0269216318816005

DO - 10.1177/0269216318816005

M3 - Article

VL - 33

SP - 221

EP - 231

JO - Palliative Medicine

JF - Palliative Medicine

SN - 1477-030X

IS - 2

ER -