Anorexia nervosa and uric acid beyond gout: An idea worth researching

Mladena Simeunovic Ostojic, Joyce Maas

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Uric acid is best known for its role in gout-the most prevalent inflammatory arthritis in humans-that is also described as an unusual complication of anorexia nervosa (AN). However, beyond gout, uric acid could also be involved in the pathophysiology and psychopathology of AN, as it has many biological functions serving as a pro- and antioxidant, neuroprotector, neurostimulant, and activator of the immune response. Further, recent research suggests that uric acid could be a biomarker of mood dysfunction, personality traits, and behavioral patterns. This article discusses the hypothesis that uric acid in AN may not be a mere innocent bystander determined solely by AN behavior and its medical complications. In contrast, the relation between uric acid and AN may have evolutionary origin and may be reciprocal, where uric acid regulates some features and pathophysiological processes of AN, including weight and metabolism regulation, oxidative stress, immunity, mood, cognition, and (hyper)activity.

Original languageEnglish
Pages (from-to)97-101
JournalInternational Journal of Eating Disorders
Volume51
Issue number2
DOIs
Publication statusPublished - 2018

Fingerprint

Uric Acid
Weights and Measures

Keywords

  • Anorexia Nervosa/etiology
  • Gout/complications
  • Humans
  • Hyperuricemia/metabolism
  • Research
  • Uric Acid/metabolism

Cite this

Simeunovic Ostojic, Mladena ; Maas, Joyce. / Anorexia nervosa and uric acid beyond gout : An idea worth researching. In: International Journal of Eating Disorders. 2018 ; Vol. 51, No. 2. pp. 97-101.
@article{f8a790fc368d4482affa9d31b4c8ad6e,
title = "Anorexia nervosa and uric acid beyond gout: An idea worth researching",
abstract = "Uric acid is best known for its role in gout-the most prevalent inflammatory arthritis in humans-that is also described as an unusual complication of anorexia nervosa (AN). However, beyond gout, uric acid could also be involved in the pathophysiology and psychopathology of AN, as it has many biological functions serving as a pro- and antioxidant, neuroprotector, neurostimulant, and activator of the immune response. Further, recent research suggests that uric acid could be a biomarker of mood dysfunction, personality traits, and behavioral patterns. This article discusses the hypothesis that uric acid in AN may not be a mere innocent bystander determined solely by AN behavior and its medical complications. In contrast, the relation between uric acid and AN may have evolutionary origin and may be reciprocal, where uric acid regulates some features and pathophysiological processes of AN, including weight and metabolism regulation, oxidative stress, immunity, mood, cognition, and (hyper)activity.",
keywords = "Anorexia Nervosa/etiology, Gout/complications, Humans, Hyperuricemia/metabolism, Research, Uric Acid/metabolism",
author = "{Simeunovic Ostojic}, Mladena and Joyce Maas",
note = "{\circledC} 2018 Wiley Periodicals, Inc.",
year = "2018",
doi = "10.1002/eat.22817",
language = "English",
volume = "51",
pages = "97--101",
journal = "International Journal of Eating Disorders",
issn = "0276-3478",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

Anorexia nervosa and uric acid beyond gout : An idea worth researching. / Simeunovic Ostojic, Mladena; Maas, Joyce.

In: International Journal of Eating Disorders, Vol. 51, No. 2, 2018, p. 97-101.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Anorexia nervosa and uric acid beyond gout

T2 - An idea worth researching

AU - Simeunovic Ostojic, Mladena

AU - Maas, Joyce

N1 - © 2018 Wiley Periodicals, Inc.

PY - 2018

Y1 - 2018

N2 - Uric acid is best known for its role in gout-the most prevalent inflammatory arthritis in humans-that is also described as an unusual complication of anorexia nervosa (AN). However, beyond gout, uric acid could also be involved in the pathophysiology and psychopathology of AN, as it has many biological functions serving as a pro- and antioxidant, neuroprotector, neurostimulant, and activator of the immune response. Further, recent research suggests that uric acid could be a biomarker of mood dysfunction, personality traits, and behavioral patterns. This article discusses the hypothesis that uric acid in AN may not be a mere innocent bystander determined solely by AN behavior and its medical complications. In contrast, the relation between uric acid and AN may have evolutionary origin and may be reciprocal, where uric acid regulates some features and pathophysiological processes of AN, including weight and metabolism regulation, oxidative stress, immunity, mood, cognition, and (hyper)activity.

AB - Uric acid is best known for its role in gout-the most prevalent inflammatory arthritis in humans-that is also described as an unusual complication of anorexia nervosa (AN). However, beyond gout, uric acid could also be involved in the pathophysiology and psychopathology of AN, as it has many biological functions serving as a pro- and antioxidant, neuroprotector, neurostimulant, and activator of the immune response. Further, recent research suggests that uric acid could be a biomarker of mood dysfunction, personality traits, and behavioral patterns. This article discusses the hypothesis that uric acid in AN may not be a mere innocent bystander determined solely by AN behavior and its medical complications. In contrast, the relation between uric acid and AN may have evolutionary origin and may be reciprocal, where uric acid regulates some features and pathophysiological processes of AN, including weight and metabolism regulation, oxidative stress, immunity, mood, cognition, and (hyper)activity.

KW - Anorexia Nervosa/etiology

KW - Gout/complications

KW - Humans

KW - Hyperuricemia/metabolism

KW - Research

KW - Uric Acid/metabolism

U2 - 10.1002/eat.22817

DO - 10.1002/eat.22817

M3 - Article

C2 - 29314231

VL - 51

SP - 97

EP - 101

JO - International Journal of Eating Disorders

JF - International Journal of Eating Disorders

SN - 0276-3478

IS - 2

ER -