Association between changes in fat distribution and biomarkers for breast cancer

Willemijn A van Gemert, Evelyn M Monninkhof, Anne M May, Sjoerd G Elias, Job van der Palen, Wouter Veldhuis, Maaike Stapper, Rebecca K Stellato, A.J. Schuit, Petra H Peeters

    Research output: Contribution to journalArticleScientificpeer-review

    Abstract

    We assessed the associations between changes in total and abdominal fat and changes in biomarkers for breast cancer risk using data of the SHAPE-2 trial. In the SHAPE-2 trial, 243 postmenopausal overweight women were included. The intervention in this trial consisted of 5-6 kg weight loss either by diet only or exercise plus diet. After 16 weeks, we measured serum sex hormones, inflammatory markers, total body fat (measured by DEXA scan) and intra and subcutaneous abdominal fat (measured by MRI). Associations between changes in different body fat depots and biomarkers were analysed by linear regression using the study cohort irrespective of randomisation to make maximal use of the distribution of changes in fat measures. We found that a loss in total body fat was associated with favourable changes in free oestradiol, free testosterone, leptin and sex hormone binding globulin (SHBG). The loss of intra-abdominal fat was associated with a decrease in free testosterone, hsCRP and leptin, and an increase in SHBG. In the multivariable analysis, the best fitted models for the biomarkers free oestradiol, SHBG leptin and adiponectin included only total body fat. For free testosterone, this was subcutaneous abdominal fat, and for hsCRP and IL-6, only intra-abdominal fat change was important. For IL-6 and adiponectin, however, associations were weak and not significant. We conclude that, in our population of healthy overweight postmenopausal women, loss of fat at different body locations was associated with changes in different types of biomarkers, known to be related to risk of breast cancer.

    Original languageEnglish
    Pages (from-to)297-305
    JournalEndocrine-Related Cancer
    Volume24
    Issue number6
    DOIs
    Publication statusPublished - Jun 2017

    Fingerprint

    Intra-Abdominal Fat
    Adipose Tissue
    Leptin
    Fats
    Adiponectin
    Interleukin-6
    Abdominal Subcutaneous Fat
    Reducing Diet
    Abdominal Fat
    Subcutaneous Fat
    Photon Absorptiometry
    Linear Models
    Exercise
    Serum

    Keywords

    • Journal Article

    Cite this

    van Gemert, W. A., Monninkhof, E. M., May, A. M., Elias, S. G., van der Palen, J., Veldhuis, W., ... Peeters, P. H. (2017). Association between changes in fat distribution and biomarkers for breast cancer. Endocrine-Related Cancer, 24(6), 297-305. https://doi.org/10.1530/ERC-16-0490
    van Gemert, Willemijn A ; Monninkhof, Evelyn M ; May, Anne M ; Elias, Sjoerd G ; van der Palen, Job ; Veldhuis, Wouter ; Stapper, Maaike ; Stellato, Rebecca K ; Schuit, A.J. ; Peeters, Petra H. / Association between changes in fat distribution and biomarkers for breast cancer. In: Endocrine-Related Cancer. 2017 ; Vol. 24, No. 6. pp. 297-305.
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    abstract = "We assessed the associations between changes in total and abdominal fat and changes in biomarkers for breast cancer risk using data of the SHAPE-2 trial. In the SHAPE-2 trial, 243 postmenopausal overweight women were included. The intervention in this trial consisted of 5-6 kg weight loss either by diet only or exercise plus diet. After 16 weeks, we measured serum sex hormones, inflammatory markers, total body fat (measured by DEXA scan) and intra and subcutaneous abdominal fat (measured by MRI). Associations between changes in different body fat depots and biomarkers were analysed by linear regression using the study cohort irrespective of randomisation to make maximal use of the distribution of changes in fat measures. We found that a loss in total body fat was associated with favourable changes in free oestradiol, free testosterone, leptin and sex hormone binding globulin (SHBG). The loss of intra-abdominal fat was associated with a decrease in free testosterone, hsCRP and leptin, and an increase in SHBG. In the multivariable analysis, the best fitted models for the biomarkers free oestradiol, SHBG leptin and adiponectin included only total body fat. For free testosterone, this was subcutaneous abdominal fat, and for hsCRP and IL-6, only intra-abdominal fat change was important. For IL-6 and adiponectin, however, associations were weak and not significant. We conclude that, in our population of healthy overweight postmenopausal women, loss of fat at different body locations was associated with changes in different types of biomarkers, known to be related to risk of breast cancer.",
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    van Gemert, WA, Monninkhof, EM, May, AM, Elias, SG, van der Palen, J, Veldhuis, W, Stapper, M, Stellato, RK, Schuit, AJ & Peeters, PH 2017, 'Association between changes in fat distribution and biomarkers for breast cancer' Endocrine-Related Cancer, vol. 24, no. 6, pp. 297-305. https://doi.org/10.1530/ERC-16-0490

    Association between changes in fat distribution and biomarkers for breast cancer. / van Gemert, Willemijn A; Monninkhof, Evelyn M; May, Anne M; Elias, Sjoerd G; van der Palen, Job; Veldhuis, Wouter; Stapper, Maaike; Stellato, Rebecca K; Schuit, A.J.; Peeters, Petra H.

    In: Endocrine-Related Cancer, Vol. 24, No. 6, 06.2017, p. 297-305.

    Research output: Contribution to journalArticleScientificpeer-review

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    AU - May, Anne M

    AU - Elias, Sjoerd G

    AU - van der Palen, Job

    AU - Veldhuis, Wouter

    AU - Stapper, Maaike

    AU - Stellato, Rebecca K

    AU - Schuit, A.J.

    AU - Peeters, Petra H

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    van Gemert WA, Monninkhof EM, May AM, Elias SG, van der Palen J, Veldhuis W et al. Association between changes in fat distribution and biomarkers for breast cancer. Endocrine-Related Cancer. 2017 Jun;24(6):297-305. https://doi.org/10.1530/ERC-16-0490