Association between exposure to HSV1 and cognitive functioning in a general population of adolescents: The TRAILS study

I. Jonker, H.C. Klein, H.E. Duivis, R.H. Yolken, J.G.M. Rosmalen, R.A. Schoevers

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Abstract

Background
Infections with different herpes viruses have been associated with cognitive functioning in psychiatric patients and healthy adults. The aim of this study was to find out whether antibodies to different herpes viruses are prospectively associated with cognitive functioning in a general adolescent population.
Methods
This study was performed in TRAILS, a large prospective general population cohort (N = 1084, 54% female, mean age 16.2 years (SD 0.6)). At age 16, immunoglobulin G antibodies against HSV1, HSV2, CMV and EBV were measured next to high sensitive C-Reactive Protein (hsCRP). Two years later, immediate memory and executive functioning were assessed using the 15 words task and the self ordered pointing task. Multiple linear regression analysis with bootstrapping was performed to study the association between viral infections and cognitive function, adjusting for gender, socioeconomic status, ethnicity, and cannabis use.
Results
Presence of HSV1 antibodies was associated with memory function ((B = −0.272, 95% CI = −0.556 to −0.016, p = 0.047)), while the association with executive functioning did not reach statistical significance (B = 0.560, 95% CI is −0.053 to 1.184, p = 0.075). The level of HSV1 antibodies was associated with both memory function (B = −0.160, 95% CI = −0.280 to −0.039, p = 0.014) and executive functioning (B = 0.296, 95% CI = 0.011 to 0.578, p = 0.046). Other herpes viruses and hsCRP were not associated with cognitive functioning.
Conclusions
Both presence and level of HSV1 antibodies are prospectively associated with reduced cognitive performance in a large cohort of adolescents.
Original languageEnglish
Article number e101549
JournalPLoS ONE
Volume9
Issue number7
DOIs
Publication statusPublished - 2014

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Viruses
Antibodies
Data storage equipment
C-Reactive Protein
Virus Diseases
Cannabis
Human Herpesvirus 4
Short-Term Memory
Linear regression
Regression analysis
Linear Models
Immunoglobulin G

Cite this

Jonker, I., Klein, H. C., Duivis, H. E., Yolken, R. H., Rosmalen, J. G. M., & Schoevers, R. A. (2014). Association between exposure to HSV1 and cognitive functioning in a general population of adolescents: The TRAILS study. PLoS ONE, 9(7), [ e101549]. https://doi.org/10.1371/journal.pone.0101549
Jonker, I. ; Klein, H.C. ; Duivis, H.E. ; Yolken, R.H. ; Rosmalen, J.G.M. ; Schoevers, R.A. / Association between exposure to HSV1 and cognitive functioning in a general population of adolescents : The TRAILS study. In: PLoS ONE. 2014 ; Vol. 9, No. 7.
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title = "Association between exposure to HSV1 and cognitive functioning in a general population of adolescents: The TRAILS study",
abstract = "BackgroundInfections with different herpes viruses have been associated with cognitive functioning in psychiatric patients and healthy adults. The aim of this study was to find out whether antibodies to different herpes viruses are prospectively associated with cognitive functioning in a general adolescent population.MethodsThis study was performed in TRAILS, a large prospective general population cohort (N = 1084, 54{\%} female, mean age 16.2 years (SD 0.6)). At age 16, immunoglobulin G antibodies against HSV1, HSV2, CMV and EBV were measured next to high sensitive C-Reactive Protein (hsCRP). Two years later, immediate memory and executive functioning were assessed using the 15 words task and the self ordered pointing task. Multiple linear regression analysis with bootstrapping was performed to study the association between viral infections and cognitive function, adjusting for gender, socioeconomic status, ethnicity, and cannabis use.ResultsPresence of HSV1 antibodies was associated with memory function ((B = −0.272, 95{\%} CI = −0.556 to −0.016, p = 0.047)), while the association with executive functioning did not reach statistical significance (B = 0.560, 95{\%} CI is −0.053 to 1.184, p = 0.075). The level of HSV1 antibodies was associated with both memory function (B = −0.160, 95{\%} CI = −0.280 to −0.039, p = 0.014) and executive functioning (B = 0.296, 95{\%} CI = 0.011 to 0.578, p = 0.046). Other herpes viruses and hsCRP were not associated with cognitive functioning.ConclusionsBoth presence and level of HSV1 antibodies are prospectively associated with reduced cognitive performance in a large cohort of adolescents.",
author = "I. Jonker and H.C. Klein and H.E. Duivis and R.H. Yolken and J.G.M. Rosmalen and R.A. Schoevers",
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Association between exposure to HSV1 and cognitive functioning in a general population of adolescents : The TRAILS study. / Jonker, I.; Klein, H.C.; Duivis, H.E.; Yolken, R.H.; Rosmalen, J.G.M.; Schoevers, R.A.

In: PLoS ONE, Vol. 9, No. 7, e101549, 2014.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Association between exposure to HSV1 and cognitive functioning in a general population of adolescents

T2 - The TRAILS study

AU - Jonker, I.

AU - Klein, H.C.

AU - Duivis, H.E.

AU - Yolken, R.H.

AU - Rosmalen, J.G.M.

AU - Schoevers, R.A.

PY - 2014

Y1 - 2014

N2 - BackgroundInfections with different herpes viruses have been associated with cognitive functioning in psychiatric patients and healthy adults. The aim of this study was to find out whether antibodies to different herpes viruses are prospectively associated with cognitive functioning in a general adolescent population.MethodsThis study was performed in TRAILS, a large prospective general population cohort (N = 1084, 54% female, mean age 16.2 years (SD 0.6)). At age 16, immunoglobulin G antibodies against HSV1, HSV2, CMV and EBV were measured next to high sensitive C-Reactive Protein (hsCRP). Two years later, immediate memory and executive functioning were assessed using the 15 words task and the self ordered pointing task. Multiple linear regression analysis with bootstrapping was performed to study the association between viral infections and cognitive function, adjusting for gender, socioeconomic status, ethnicity, and cannabis use.ResultsPresence of HSV1 antibodies was associated with memory function ((B = −0.272, 95% CI = −0.556 to −0.016, p = 0.047)), while the association with executive functioning did not reach statistical significance (B = 0.560, 95% CI is −0.053 to 1.184, p = 0.075). The level of HSV1 antibodies was associated with both memory function (B = −0.160, 95% CI = −0.280 to −0.039, p = 0.014) and executive functioning (B = 0.296, 95% CI = 0.011 to 0.578, p = 0.046). Other herpes viruses and hsCRP were not associated with cognitive functioning.ConclusionsBoth presence and level of HSV1 antibodies are prospectively associated with reduced cognitive performance in a large cohort of adolescents.

AB - BackgroundInfections with different herpes viruses have been associated with cognitive functioning in psychiatric patients and healthy adults. The aim of this study was to find out whether antibodies to different herpes viruses are prospectively associated with cognitive functioning in a general adolescent population.MethodsThis study was performed in TRAILS, a large prospective general population cohort (N = 1084, 54% female, mean age 16.2 years (SD 0.6)). At age 16, immunoglobulin G antibodies against HSV1, HSV2, CMV and EBV were measured next to high sensitive C-Reactive Protein (hsCRP). Two years later, immediate memory and executive functioning were assessed using the 15 words task and the self ordered pointing task. Multiple linear regression analysis with bootstrapping was performed to study the association between viral infections and cognitive function, adjusting for gender, socioeconomic status, ethnicity, and cannabis use.ResultsPresence of HSV1 antibodies was associated with memory function ((B = −0.272, 95% CI = −0.556 to −0.016, p = 0.047)), while the association with executive functioning did not reach statistical significance (B = 0.560, 95% CI is −0.053 to 1.184, p = 0.075). The level of HSV1 antibodies was associated with both memory function (B = −0.160, 95% CI = −0.280 to −0.039, p = 0.014) and executive functioning (B = 0.296, 95% CI = 0.011 to 0.578, p = 0.046). Other herpes viruses and hsCRP were not associated with cognitive functioning.ConclusionsBoth presence and level of HSV1 antibodies are prospectively associated with reduced cognitive performance in a large cohort of adolescents.

U2 - 10.1371/journal.pone.0101549

DO - 10.1371/journal.pone.0101549

M3 - Article

VL - 9

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 7

M1 - e101549

ER -