Association between peripheral neuropathy and sleep quality among colorectal cancer patients from diagnosis until 2-year follow-up: Results from the PROFILES registry

C. Bonhof*, L.V. van de Poll-Franse, I.H.J.T. de Hingh, G.M. Nefs, G. Vreugdenhil, F. Mols

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Purpose
Studies on the association between peripheral neuropathy (PN) and patient-reported outcomes have mostly overlooked sleep quality. Therefore, we aimed to assess the association between PN and sleep quality in a population-based sample of colorectal cancer (CRC) patients up two years after diagnosis.

Methods
All newly diagnosed CRC patients from four Dutch hospitals were eligible for participation. Patients (N=340) completed questionnaires about PN (EORTC QLQ-CIPN20) and sleep (PSQI) before initial treatment (baseline) and one and two years after diagnosis.

Results
Patients who developed sensory PN (n=76) or motor PN (n=79) after treatment more often reported poor sleeping scores (PSQI>5) compared with those who did not develop SPN or MPN at 1-year (SPN: 38% vs. 261%, MPN: 37% vs. 14%) and 2-year follow-up (SPN: 38 vs. 23%, MPN: 37% vs. 18%) (all p<0.05). Overall, results showed that among patients who did not develop SPN or MPN, sleep quality improved after baseline, while among patients with SPN or MPN, sleep quality did not improve at one and two years after diagnosis.

Conclusions
Both SPN and MPN were significantly associated with the course of sleep quality among CRC patients up to two years after diagnosis. Clinicians should be encouraged to discuss sleep quality with their patients who either report PN or are at risk of developing PN. 
Implications for survivors: Improving sleep quality among survivors with PN is important, either by reducing PN symptoms, or directly targeting sleep
Original languageEnglish
Number of pages12
JournalJournal of Cancer Survivorship
DOIs
Publication statusE-pub ahead of print - 2022

Keywords

  • Colorectal cancer
  • INSOMNIA
  • OF-LIFE
  • PAIN
  • PREVALENCE
  • PROFILES
  • Peripheral neuropathy
  • QUESTIONNAIRE
  • Sleep

Fingerprint

Dive into the research topics of 'Association between peripheral neuropathy and sleep quality among colorectal cancer patients from diagnosis until 2-year follow-up: Results from the PROFILES registry'. Together they form a unique fingerprint.

Cite this