TY - JOUR
T1 - Associations between alcohol consumption and anxiety, depression, and health-related quality of life in colorectal cancer survivors
AU - Revesz, Dora
AU - Bours, Martijn J. L.
AU - Wegdam, Johannes A.
AU - Keulen, Eric T. P.
AU - Breukink, Stephanie O.
AU - Slooter, Gerrit D.
AU - Vogelaar, F. Jeroen
AU - Weijenberg, Matty P.
AU - Mols, Floortje
N1 - Funding Information:
The current study was supported by ERAB: The European Foundation for Alcohol Research (number EA 18 20). The EnCoRe study was supported by grants from the Stichting Alpe d’HuZes within the research program “Leven met kanker” of the Dutch Cancer Society (Grant No. UM-2010-4867 and UM-2012-5653), grants from Kankeronderzoekfonds Limburg as part of Health Foundation Limburg (Grant No. 00005739), Wereld Kanker Onderzoek Fonds (WKOF), as part of the World Cancer Research Fund International grant program (grant number 2016/1620), and ERA-NET on Translational Cancer Research (TRANSCAN/Dutch Cancer Society, the Netherlands, project no. UM 2014-6877).
PY - 2022
Y1 - 2022
N2 - Purpose Alcohol consumption is a major risk factor for colorectal cancer (CRC). It is currently poorly understood, however, how alcohol and different alcoholic beverage types are related to psychosocial outcomes in CRC survivors. Methods We used data of N = 910 CRC survivors from the pooled EnCoRe and PROCORE cohorts and harmonized them into five time points: at diagnosis and 3, 6, 12, and 24 months post-diagnosis. Generalized estimated equation models were used to examine longitudinal associations of alcohol consumption, including consumption of beer, wine, and liquor, with anxiety, depression, and health-related quality of life (HRQoL), while correcting for sociodemographic, lifestyle, and clinical factors. Results Survivors were on average 67 years and 37% was female. In the first 2 years post-diagnosis, survivors who consumed more alcoholic drinks/week reported lower anxiety and depressive symptoms and better HRQoL on all domains and symptom scales. This was the case for moderate and heavy amounts of alcohol and mostly for consuming beer and wine, but not for liquor. Associations were more often significant for men and for younger persons (< 67 years at baseline). Conclusions Generally, alcohol consumption was observed to be longitudinally related to less anxiety and depression and better HRQoL in CRC survivors. Implications for Cancer Survivors Although alcohol consumption is generally unfavorable due to increased risk of carcinogenesis and worse prognosis after CRC, it seems to be associated with better psychosocial outcomes in the first 2 years after diagnosis and treatment. More research is needed to gain knowledge about reasons for drinking and causality.Netherlands Trial Registry (www.trialregister.nl, NL6904)
AB - Purpose Alcohol consumption is a major risk factor for colorectal cancer (CRC). It is currently poorly understood, however, how alcohol and different alcoholic beverage types are related to psychosocial outcomes in CRC survivors. Methods We used data of N = 910 CRC survivors from the pooled EnCoRe and PROCORE cohorts and harmonized them into five time points: at diagnosis and 3, 6, 12, and 24 months post-diagnosis. Generalized estimated equation models were used to examine longitudinal associations of alcohol consumption, including consumption of beer, wine, and liquor, with anxiety, depression, and health-related quality of life (HRQoL), while correcting for sociodemographic, lifestyle, and clinical factors. Results Survivors were on average 67 years and 37% was female. In the first 2 years post-diagnosis, survivors who consumed more alcoholic drinks/week reported lower anxiety and depressive symptoms and better HRQoL on all domains and symptom scales. This was the case for moderate and heavy amounts of alcohol and mostly for consuming beer and wine, but not for liquor. Associations were more often significant for men and for younger persons (< 67 years at baseline). Conclusions Generally, alcohol consumption was observed to be longitudinally related to less anxiety and depression and better HRQoL in CRC survivors. Implications for Cancer Survivors Although alcohol consumption is generally unfavorable due to increased risk of carcinogenesis and worse prognosis after CRC, it seems to be associated with better psychosocial outcomes in the first 2 years after diagnosis and treatment. More research is needed to gain knowledge about reasons for drinking and causality.Netherlands Trial Registry (www.trialregister.nl, NL6904)
KW - Alcohol Drinking/adverse effects
KW - Anxiety/epidemiology
KW - Colorectal Neoplasms/epidemiology
KW - Depression/epidemiology
KW - Female
KW - Humans
KW - Male
KW - Quality of Life
KW - Survivors/psychology
UR - http://www.trialregister.nl, NL6904
UR - http://www.scopus.com/inward/record.url?scp=85115112487&partnerID=8YFLogxK
U2 - 10.1007/s11764-021-01090-y
DO - 10.1007/s11764-021-01090-y
M3 - Article
C2 - 34529261
SN - 1932-2259
VL - 16
SP - 988
EP - 997
JO - Journal of Cancer Survivorship
JF - Journal of Cancer Survivorship
IS - 5
ER -