Previous studies focused mostly on predicting the adjustment of adolescents based on distinct coping strategies. However, people generally do not use only one coping strategy, but rather select from a repertoire of coping strategies. This study aimed to identify these repertoires by categorizing adolescents by the coping strategies they use and by examining whether these typologies moderate the well-established relationship between negative affect and interpersonal relationships (e.g., close, acquaintances, alone). The experience sampling method (ESM) was used to assess negative affect and the interpersonal relationships of 280 adolescents (Mage = 14.19, SDage = .54; 59% girls) at nine randomly chosen times on six consecutive days. Coping strategies were measured with a questionnaire prior to ESM. Latent profile analysis revealed two profiles: passive copers and active copers. Furthermore, all participants reported less negative affect when they were with people with whom they had close interpersonal relationships (family and friends) than when they were with acquaintances (class or teammates) or alone. No moderation of coping typologies was revealed. The results underscore the importance of close interpersonal relationships to buffer against negative affect during adolescence and support the notion that the relationship between negative affect and close interpersonal relationships is strong, as it is not moderated by the method used to deal with negative events.