TY - JOUR
T1 - Associations of the dietary World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations with patient-reported outcomes in colorectal cancer survivors 2–10 years post-diagnosis
T2 - A cross-sectional analysis
AU - Kenkhuis, M.L.
AU - van der Linden, B.W.A.
AU - Breedveld-Peters, J.J.L.
AU - Koole, J.L.
AU - van Roekel, E.H.
AU - Breukink, S.O.
AU - Mols, F.
AU - Weijenberg, M.P.
AU - Bours, M.J.L.
N1 - Funding Information:
M. K. is funded by the Wereld Kanker Onderzoek Fonds (WKOF), as part of the World Cancer Research Fund International grant programme (grant no. 2017/1619). J. J. L. B.-P. was funded and J. L. K. is currently funded by Kankeronderzoekfonds Limburg as part of Health Foundation Limburg (grant no. 00005739). E. H. van R. is funded by the Wereld Kanker Onderzoek Fonds (WKOF), as part of the World Cancer Research Fund International grant programme (grant no. 2016/1620). The EnCoRe study was also funded by grants from the Stichting Alpe d’HuZes within the research programme ‘Leven met kanker’ of the Dutch Cancer Society (grant no. UM-2010-4867 and UM-2012-5653).
PY - 2021/5/28
Y1 - 2021/5/28
N2 - The World Cancer Research Fund and American Institute for Cancer Research (WCRF/AICR) advise cancer survivors to follow their lifestyle recommendations for cancer prevention. Adhering to these recommendations may have beneficial effects on patient-reported outcomes after a cancer diagnosis, but evidence is scarce. We aimed to assess associations of the individual dietary WCRF/AICR recommendations regarding fruit and vegetables, fibre, fast foods, red and processed meat, sugar-sweetened drinks and alcohol consumption with patient-reported outcomes in colorectal cancer (CRC) survivors. Cross-sectional data of 150 stage I–III CRC survivors, 2–10 years post-diagnosis, were used. Dietary intake was measured by 7-d dietary records. Validated questionnaires were used to measure health-related quality of life (HRQoL), fatigue and neuropathy. Confounder-adjusted linear regression models were used to analyse associations of each WCRF/AICR dietary recommendation with patient-reported outcomes. Higher vegetable intake (per 50 g) was associated with better global QoL (β 2·6; 95 % CI 0·6, 4·7), better physical functioning (3·3; 1·2, 5·5) and lower levels of fatigue (−4·5; −7·6, −1·4). Higher fruit and vegetables intake (per 100 g) was associated with better physical functioning (3·2; 0·8, 5·5) and higher intake of energy-dense food (per 100 kJ/100 g) with worse physical functioning (−4·2; −7·1, −1·2). No associations of dietary recommendations with neuropathy were found. These findings suggest that adhering to specific dietary WCRF/AICR recommendations is associated with better HRQoL and less fatigue in CRC survivors. Although the recommendations regarding healthy dietary habits may be beneficial for the well-being of CRC survivors, longitudinal research is warranted to gain insight into the direction of associations.
AB - The World Cancer Research Fund and American Institute for Cancer Research (WCRF/AICR) advise cancer survivors to follow their lifestyle recommendations for cancer prevention. Adhering to these recommendations may have beneficial effects on patient-reported outcomes after a cancer diagnosis, but evidence is scarce. We aimed to assess associations of the individual dietary WCRF/AICR recommendations regarding fruit and vegetables, fibre, fast foods, red and processed meat, sugar-sweetened drinks and alcohol consumption with patient-reported outcomes in colorectal cancer (CRC) survivors. Cross-sectional data of 150 stage I–III CRC survivors, 2–10 years post-diagnosis, were used. Dietary intake was measured by 7-d dietary records. Validated questionnaires were used to measure health-related quality of life (HRQoL), fatigue and neuropathy. Confounder-adjusted linear regression models were used to analyse associations of each WCRF/AICR dietary recommendation with patient-reported outcomes. Higher vegetable intake (per 50 g) was associated with better global QoL (β 2·6; 95 % CI 0·6, 4·7), better physical functioning (3·3; 1·2, 5·5) and lower levels of fatigue (−4·5; −7·6, −1·4). Higher fruit and vegetables intake (per 100 g) was associated with better physical functioning (3·2; 0·8, 5·5) and higher intake of energy-dense food (per 100 kJ/100 g) with worse physical functioning (−4·2; −7·1, −1·2). No associations of dietary recommendations with neuropathy were found. These findings suggest that adhering to specific dietary WCRF/AICR recommendations is associated with better HRQoL and less fatigue in CRC survivors. Although the recommendations regarding healthy dietary habits may be beneficial for the well-being of CRC survivors, longitudinal research is warranted to gain insight into the direction of associations.
KW - BODY-MASS INDEX
KW - CHEMOTHERAPY
KW - COLON-CANCER
KW - Colorectal cancer survivorship
KW - Diet
KW - Fatigue
KW - HEALTH
KW - Health-related quality of life
KW - INDUCED PERIPHERAL NEUROPATHY
KW - Lifestyle recommendations
KW - MEDITERRANEAN DIET
KW - Neuropathy
KW - PHYSICAL-ACTIVITY
KW - QUALITY-OF-LIFE
KW - STYLE FACTORS
KW - VEGETABLE INTAKE
UR - http://www.scopus.com/inward/record.url?scp=85094208910&partnerID=8YFLogxK
U2 - 10.1017/S0007114520003487
DO - 10.1017/S0007114520003487
M3 - Article
SN - 0007-1145
VL - 125
SP - 1188
EP - 1200
JO - British Journal of Nutrition
JF - British Journal of Nutrition
IS - 10
ER -