Baseline dimensional psychopathology and future mood disorder onset

Findings from the Dutch Bipolar Offspring Study

E. Mesman, W. A. Nolen, L.. Keijsers, M. H. J. Hillegers*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Objective:

To identify the early signs of mood disorder development, specifically bipolar disorder (BD), in a population at familial risk for BD.

Method:

The sample included 107 Dutch adolescent bipolar offspring (age 12-21) followed into adulthood (age 22-32). Lifetime DSM-IV axis I diagnoses were examined at baseline, 1-, 5-, and 12-year follow-up. Symptoms were assessed at baseline on a 3-point Likert scale at baseline with the K-SADS-PL and were analyzed using symptom and sum scores. As observed in previous studies, BD typically starts with other mood disorders. Therefore, the sample was stratified in offspring with a mood diagnosis (n = 29) and without (n = 78) at baseline.

Results:

Subthreshold manic experiences proved the strongest predictor of BD conversion (n = 10; HR2.16, CI95% 1.23-3.78). At symptom level, elated mood, decreased need of sleep, racing thoughts, suicidal ideation, and middle insomnia were significantly associated with BD conversion. Depressive symptoms proved the strongest predictor for first mood episode onset (n = 28; HR1.27, CI95% 1.02-1.58).

Conclusion:

This study extends our knowledge of prodromal manifestations of BD in a high-risk population. Although preliminary, findings of this study provide potential targets for early identification and underscore the importance of detailed assessment of manic symptomatology in bipolar offspring.

Original languageEnglish
Pages (from-to)201-209
JournalActa Psychiatrica Scandinavica
Volume136
Issue number2
DOIs
Publication statusPublished - Aug 2017

Keywords

  • bipolar disorder
  • family studies
  • risk factors
  • HIGH-RISK
  • SPECTRUM DISORDERS
  • SUICIDAL IDEATION
  • MENTAL-DISORDERS
  • PARENTS
  • CHILDREN
  • DURATION
  • ADOLESCENTS
  • PRECURSORS
  • YOUTH

Cite this

@article{40af7d2730184892bcce18c324dcaeb7,
title = "Baseline dimensional psychopathology and future mood disorder onset: Findings from the Dutch Bipolar Offspring Study",
abstract = "Objective: To identify the early signs of mood disorder development, specifically bipolar disorder (BD), in a population at familial risk for BD.Method: The sample included 107 Dutch adolescent bipolar offspring (age 12-21) followed into adulthood (age 22-32). Lifetime DSM-IV axis I diagnoses were examined at baseline, 1-, 5-, and 12-year follow-up. Symptoms were assessed at baseline on a 3-point Likert scale at baseline with the K-SADS-PL and were analyzed using symptom and sum scores. As observed in previous studies, BD typically starts with other mood disorders. Therefore, the sample was stratified in offspring with a mood diagnosis (n = 29) and without (n = 78) at baseline.Results: Subthreshold manic experiences proved the strongest predictor of BD conversion (n = 10; HR2.16, CI95{\%} 1.23-3.78). At symptom level, elated mood, decreased need of sleep, racing thoughts, suicidal ideation, and middle insomnia were significantly associated with BD conversion. Depressive symptoms proved the strongest predictor for first mood episode onset (n = 28; HR1.27, CI95{\%} 1.02-1.58).Conclusion: This study extends our knowledge of prodromal manifestations of BD in a high-risk population. Although preliminary, findings of this study provide potential targets for early identification and underscore the importance of detailed assessment of manic symptomatology in bipolar offspring.",
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author = "E. Mesman and Nolen, {W. A.} and L.. Keijsers and Hillegers, {M. H. J.}",
year = "2017",
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doi = "10.1111/acps.12739",
language = "English",
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Baseline dimensional psychopathology and future mood disorder onset : Findings from the Dutch Bipolar Offspring Study. / Mesman, E.; Nolen, W. A.; Keijsers, L..; Hillegers, M. H. J.

In: Acta Psychiatrica Scandinavica, Vol. 136, No. 2, 08.2017, p. 201-209.

Research output: Contribution to journalArticleScientificpeer-review

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T1 - Baseline dimensional psychopathology and future mood disorder onset

T2 - Findings from the Dutch Bipolar Offspring Study

AU - Mesman, E.

AU - Nolen, W. A.

AU - Keijsers, L..

AU - Hillegers, M. H. J.

PY - 2017/8

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N2 - Objective: To identify the early signs of mood disorder development, specifically bipolar disorder (BD), in a population at familial risk for BD.Method: The sample included 107 Dutch adolescent bipolar offspring (age 12-21) followed into adulthood (age 22-32). Lifetime DSM-IV axis I diagnoses were examined at baseline, 1-, 5-, and 12-year follow-up. Symptoms were assessed at baseline on a 3-point Likert scale at baseline with the K-SADS-PL and were analyzed using symptom and sum scores. As observed in previous studies, BD typically starts with other mood disorders. Therefore, the sample was stratified in offspring with a mood diagnosis (n = 29) and without (n = 78) at baseline.Results: Subthreshold manic experiences proved the strongest predictor of BD conversion (n = 10; HR2.16, CI95% 1.23-3.78). At symptom level, elated mood, decreased need of sleep, racing thoughts, suicidal ideation, and middle insomnia were significantly associated with BD conversion. Depressive symptoms proved the strongest predictor for first mood episode onset (n = 28; HR1.27, CI95% 1.02-1.58).Conclusion: This study extends our knowledge of prodromal manifestations of BD in a high-risk population. Although preliminary, findings of this study provide potential targets for early identification and underscore the importance of detailed assessment of manic symptomatology in bipolar offspring.

AB - Objective: To identify the early signs of mood disorder development, specifically bipolar disorder (BD), in a population at familial risk for BD.Method: The sample included 107 Dutch adolescent bipolar offspring (age 12-21) followed into adulthood (age 22-32). Lifetime DSM-IV axis I diagnoses were examined at baseline, 1-, 5-, and 12-year follow-up. Symptoms were assessed at baseline on a 3-point Likert scale at baseline with the K-SADS-PL and were analyzed using symptom and sum scores. As observed in previous studies, BD typically starts with other mood disorders. Therefore, the sample was stratified in offspring with a mood diagnosis (n = 29) and without (n = 78) at baseline.Results: Subthreshold manic experiences proved the strongest predictor of BD conversion (n = 10; HR2.16, CI95% 1.23-3.78). At symptom level, elated mood, decreased need of sleep, racing thoughts, suicidal ideation, and middle insomnia were significantly associated with BD conversion. Depressive symptoms proved the strongest predictor for first mood episode onset (n = 28; HR1.27, CI95% 1.02-1.58).Conclusion: This study extends our knowledge of prodromal manifestations of BD in a high-risk population. Although preliminary, findings of this study provide potential targets for early identification and underscore the importance of detailed assessment of manic symptomatology in bipolar offspring.

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KW - family studies

KW - risk factors

KW - HIGH-RISK

KW - SPECTRUM DISORDERS

KW - SUICIDAL IDEATION

KW - MENTAL-DISORDERS

KW - PARENTS

KW - CHILDREN

KW - DURATION

KW - ADOLESCENTS

KW - PRECURSORS

KW - YOUTH

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JF - Acta Psychiatrica Scandinavica

SN - 0001-690X

IS - 2

ER -