Behavioral correlates of changes in hippocampal gray matter structure during acquisition of foreign vocabulary

Martin Bellander, Rasmus Berggren, Johan Mårtensson, Yvonne Brehmer, Elisabeth Wenger, Tie-qiang Li, Nils C. Bodammer, Yee-lee Shing, Markus Werkle-bergner, Martin Lövdén

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Experience can affect human gray matter volume. The behavioral correlates of individual differences in such brain changes are not well understood. In a group of Swedish individuals studying Italian as a foreign language, we investigated associations among time spent studying, acquired vocabulary, baseline performance on memory tasks, and gray matter changes. As a way of studying episodic memory training, the language learning focused on acquiring foreign vocabulary and lasted for 10weeks. T1-weighted structural magnetic resonance imaging and cognitive testing were performed before and after the studies. Learning behavior was monitored via participants' use of a smartphone application dedicated to the study of vocabulary. A whole-brain analysis showed larger changes in gray matter structure of the right hippocampus in the experimental group (N=33) compared to an active control group (N=23). A first path analyses revealed that time spent studying rather than acquired knowledge significantly predicted change in gray matter structure. However, this association was not significant when adding performance on baseline memory measures into the model, instead only the participants' performance on a short-term memory task with highly similar distractors predicted the change. This measure may tap similar individual difference factors as those involved in gray matter plasticity of the hippocampus.
Original languageEnglish
Pages (from-to)205-213
JournalNeuroimage
Volume131
DOIs
Publication statusPublished - 2016
Externally publishedYes

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Vocabulary
Individuality
Language
Episodic Memory
Short-Term Memory

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Bellander, Martin ; Berggren, Rasmus ; Mårtensson, Johan ; Brehmer, Yvonne ; Wenger, Elisabeth ; Li, Tie-qiang ; Bodammer, Nils C. ; Shing, Yee-lee ; Werkle-bergner, Markus ; Lövdén, Martin. / Behavioral correlates of changes in hippocampal gray matter structure during acquisition of foreign vocabulary. In: Neuroimage. 2016 ; Vol. 131. pp. 205-213.
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title = "Behavioral correlates of changes in hippocampal gray matter structure during acquisition of foreign vocabulary",
abstract = "Experience can affect human gray matter volume. The behavioral correlates of individual differences in such brain changes are not well understood. In a group of Swedish individuals studying Italian as a foreign language, we investigated associations among time spent studying, acquired vocabulary, baseline performance on memory tasks, and gray matter changes. As a way of studying episodic memory training, the language learning focused on acquiring foreign vocabulary and lasted for 10weeks. T1-weighted structural magnetic resonance imaging and cognitive testing were performed before and after the studies. Learning behavior was monitored via participants' use of a smartphone application dedicated to the study of vocabulary. A whole-brain analysis showed larger changes in gray matter structure of the right hippocampus in the experimental group (N=33) compared to an active control group (N=23). A first path analyses revealed that time spent studying rather than acquired knowledge significantly predicted change in gray matter structure. However, this association was not significant when adding performance on baseline memory measures into the model, instead only the participants' performance on a short-term memory task with highly similar distractors predicted the change. This measure may tap similar individual difference factors as those involved in gray matter plasticity of the hippocampus.",
author = "Martin Bellander and Rasmus Berggren and Johan M{\aa}rtensson and Yvonne Brehmer and Elisabeth Wenger and Tie-qiang Li and Bodammer, {Nils C.} and Yee-lee Shing and Markus Werkle-bergner and Martin L{\"o}vd{\'e}n",
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Bellander, M, Berggren, R, Mårtensson, J, Brehmer, Y, Wenger, E, Li, T, Bodammer, NC, Shing, Y, Werkle-bergner, M & Lövdén, M 2016, 'Behavioral correlates of changes in hippocampal gray matter structure during acquisition of foreign vocabulary', Neuroimage, vol. 131, pp. 205-213. https://doi.org/10.1016/j.neuroimage.2015.10.020

Behavioral correlates of changes in hippocampal gray matter structure during acquisition of foreign vocabulary. / Bellander, Martin; Berggren, Rasmus; Mårtensson, Johan; Brehmer, Yvonne; Wenger, Elisabeth; Li, Tie-qiang; Bodammer, Nils C.; Shing, Yee-lee; Werkle-bergner, Markus; Lövdén, Martin.

In: Neuroimage, Vol. 131, 2016, p. 205-213.

Research output: Contribution to journalArticleScientificpeer-review

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AU - Berggren, Rasmus

AU - Mårtensson, Johan

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AU - Bodammer, Nils C.

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AU - Lövdén, Martin

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