Beta-blockers and depression in elderly hypertension patients in primary care

Lianne Ringoir, Susanne S. Pedersen, Jos W. M. G. Widdershoven, Francois Pouwer, Josephine M. L. Keyzer, Arnold C. Romeijnders, Victor J. M. Pop

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Background and Objectives:
Previous findings regarding a possible association between beta-blocker use and depression are mixed. To our knowledge there have been no studies investigating the association of beta-blockers with depression in primary care hypertension patients without previous myocardial infarction. The aim of this study was to determine the relation between lipophilic beta-blocker use and depression in elderly primary care patients with hypertension.
Methods:
This was a cross-sectional study in primary care practices located in the South of The Netherlands. Primary care hypertension patients without previous myocardial infarction or heart failure (n=573), aged between 60 and 85 years (mean age=70±6.6), were included. All patients underwent a structured interview that included a self-report questionnaire to assess depression (PHQ-9), which was divided in four groups (PHQ-9 score of 0, 1–3, 4–8, 9 or higher).
Results:
A PHQ-9 score of 0 was more prevalent in non-beta-blocker users versus lipophilic beta-blocker users (46% versus 35%), a PHQ-9 score of 4–8 was less prevalent in non-beta-blocker users as compared with lipophilic beta-blocker users (14% versus 25%). A chi-squared test showed that lipophilic beta-blocker users as compared to non-beta-blockers users were more likely to be in a higher depression category. Ordinal regression showed a significant relationship between use of lipophilic beta-blockers and depression (OR=1.60, 95% CI=1.08–2.36) when adjusting for potential confounders.
Conclusions:
Our findings show that primary care hypertension patients who use a lipophilic beta-blocker are more likely to have higher depression scores than those who do not use a lipophilic beta-blocker.
Original languageEnglish
Pages (from-to)447-453
JournalFamily Medicine
Volume46
Issue number6
Publication statusPublished - 2014

Cite this

Ringoir, Lianne ; Pedersen, Susanne S. ; Widdershoven, Jos W. M. G. ; Pouwer, Francois ; Keyzer, Josephine M. L. ; Romeijnders, Arnold C. ; Pop, Victor J. M. / Beta-blockers and depression in elderly hypertension patients in primary care. In: Family Medicine. 2014 ; Vol. 46, No. 6. pp. 447-453.
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title = "Beta-blockers and depression in elderly hypertension patients in primary care",
abstract = "Background and Objectives: Previous findings regarding a possible association between beta-blocker use and depression are mixed. To our knowledge there have been no studies investigating the association of beta-blockers with depression in primary care hypertension patients without previous myocardial infarction. The aim of this study was to determine the relation between lipophilic beta-blocker use and depression in elderly primary care patients with hypertension.Methods: This was a cross-sectional study in primary care practices located in the South of The Netherlands. Primary care hypertension patients without previous myocardial infarction or heart failure (n=573), aged between 60 and 85 years (mean age=70±6.6), were included. All patients underwent a structured interview that included a self-report questionnaire to assess depression (PHQ-9), which was divided in four groups (PHQ-9 score of 0, 1–3, 4–8, 9 or higher).Results: A PHQ-9 score of 0 was more prevalent in non-beta-blocker users versus lipophilic beta-blocker users (46{\%} versus 35{\%}), a PHQ-9 score of 4–8 was less prevalent in non-beta-blocker users as compared with lipophilic beta-blocker users (14{\%} versus 25{\%}). A chi-squared test showed that lipophilic beta-blocker users as compared to non-beta-blockers users were more likely to be in a higher depression category. Ordinal regression showed a significant relationship between use of lipophilic beta-blockers and depression (OR=1.60, 95{\%} CI=1.08–2.36) when adjusting for potential confounders.Conclusions: Our findings show that primary care hypertension patients who use a lipophilic beta-blocker are more likely to have higher depression scores than those who do not use a lipophilic beta-blocker.",
author = "Lianne Ringoir and Pedersen, {Susanne S.} and Widdershoven, {Jos W. M. G.} and Francois Pouwer and Keyzer, {Josephine M. L.} and Romeijnders, {Arnold C.} and Pop, {Victor J. M.}",
year = "2014",
language = "English",
volume = "46",
pages = "447--453",
journal = "Family Medicine",
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Ringoir, L, Pedersen, SS, Widdershoven, JWMG, Pouwer, F, Keyzer, JML, Romeijnders, AC & Pop, VJM 2014, 'Beta-blockers and depression in elderly hypertension patients in primary care', Family Medicine, vol. 46, no. 6, pp. 447-453.

Beta-blockers and depression in elderly hypertension patients in primary care. / Ringoir, Lianne; Pedersen, Susanne S.; Widdershoven, Jos W. M. G.; Pouwer, Francois; Keyzer, Josephine M. L.; Romeijnders, Arnold C.; Pop, Victor J. M.

In: Family Medicine, Vol. 46, No. 6, 2014, p. 447-453.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Beta-blockers and depression in elderly hypertension patients in primary care

AU - Ringoir, Lianne

AU - Pedersen, Susanne S.

AU - Widdershoven, Jos W. M. G.

AU - Pouwer, Francois

AU - Keyzer, Josephine M. L.

AU - Romeijnders, Arnold C.

AU - Pop, Victor J. M.

PY - 2014

Y1 - 2014

N2 - Background and Objectives: Previous findings regarding a possible association between beta-blocker use and depression are mixed. To our knowledge there have been no studies investigating the association of beta-blockers with depression in primary care hypertension patients without previous myocardial infarction. The aim of this study was to determine the relation between lipophilic beta-blocker use and depression in elderly primary care patients with hypertension.Methods: This was a cross-sectional study in primary care practices located in the South of The Netherlands. Primary care hypertension patients without previous myocardial infarction or heart failure (n=573), aged between 60 and 85 years (mean age=70±6.6), were included. All patients underwent a structured interview that included a self-report questionnaire to assess depression (PHQ-9), which was divided in four groups (PHQ-9 score of 0, 1–3, 4–8, 9 or higher).Results: A PHQ-9 score of 0 was more prevalent in non-beta-blocker users versus lipophilic beta-blocker users (46% versus 35%), a PHQ-9 score of 4–8 was less prevalent in non-beta-blocker users as compared with lipophilic beta-blocker users (14% versus 25%). A chi-squared test showed that lipophilic beta-blocker users as compared to non-beta-blockers users were more likely to be in a higher depression category. Ordinal regression showed a significant relationship between use of lipophilic beta-blockers and depression (OR=1.60, 95% CI=1.08–2.36) when adjusting for potential confounders.Conclusions: Our findings show that primary care hypertension patients who use a lipophilic beta-blocker are more likely to have higher depression scores than those who do not use a lipophilic beta-blocker.

AB - Background and Objectives: Previous findings regarding a possible association between beta-blocker use and depression are mixed. To our knowledge there have been no studies investigating the association of beta-blockers with depression in primary care hypertension patients without previous myocardial infarction. The aim of this study was to determine the relation between lipophilic beta-blocker use and depression in elderly primary care patients with hypertension.Methods: This was a cross-sectional study in primary care practices located in the South of The Netherlands. Primary care hypertension patients without previous myocardial infarction or heart failure (n=573), aged between 60 and 85 years (mean age=70±6.6), were included. All patients underwent a structured interview that included a self-report questionnaire to assess depression (PHQ-9), which was divided in four groups (PHQ-9 score of 0, 1–3, 4–8, 9 or higher).Results: A PHQ-9 score of 0 was more prevalent in non-beta-blocker users versus lipophilic beta-blocker users (46% versus 35%), a PHQ-9 score of 4–8 was less prevalent in non-beta-blocker users as compared with lipophilic beta-blocker users (14% versus 25%). A chi-squared test showed that lipophilic beta-blocker users as compared to non-beta-blockers users were more likely to be in a higher depression category. Ordinal regression showed a significant relationship between use of lipophilic beta-blockers and depression (OR=1.60, 95% CI=1.08–2.36) when adjusting for potential confounders.Conclusions: Our findings show that primary care hypertension patients who use a lipophilic beta-blocker are more likely to have higher depression scores than those who do not use a lipophilic beta-blocker.

M3 - Article

VL - 46

SP - 447

EP - 453

JO - Family Medicine

JF - Family Medicine

SN - 0472-3225

IS - 6

ER -

Ringoir L, Pedersen SS, Widdershoven JWMG, Pouwer F, Keyzer JML, Romeijnders AC et al. Beta-blockers and depression in elderly hypertension patients in primary care. Family Medicine. 2014;46(6):447-453.