Between-site reliability of startle prepulse inhibition across two early psychosis consortia

K.S. Cadenhead, J. Addington, T.D. Cannon, B.A. Cornblatt, C. de La Fuente-Sandoval, D.H. Mathalon, D.O. Perkins, L.J. Seidman, M. Tsuang, E.F. Walker, S.W. Woods, P. Bachman, A. Belger, R.E. Carrion, F.C.L. Donkers, E. Duncan, J. Johannesen, P. Leon-Ortiz, G. Light, A. MondragonM. Niznikiewicz, J. Nunag, B.J. Roach, R. Solis-Vivanco

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Prepulse inhibition (PPI) and reactivity of the acoustic startle response are widely used biobehavioral markers in psychopathology research. Previous studies have demonstrated that PPI and startle reactivity exhibit substantial within-site stability; however, between-site stability has not been established. In two separate consortia investigating biomarkers of early psychosis, traveling participants studies were carried out as a part of quality assurance procedures to assess the fidelity of data across sites. In the North American Prodromal Longitudinal Studies (NAPLS) consortium, eight normal participants traveled to each of the eight NAPLS sites and were tested twice at each site on the startle PPI paradigm. In preparation for a binational study, 10 healthy participants were assessed twice in both San Diego and Mexico City. Intraclass correlations between and within sites were significant for PPI and startle response parameters, confirming the reliability of startle measures across sites in both consortia. There were between-site differences in startle magnitude in the NAPLS study that did not appear to be related to methods or equipment. In planning multisite studies, it is essential to institute quality assurance procedures early and establish between-site reliability to assure comparable data across sites.
Original languageEnglish
Pages (from-to)626-630
JournalNeuroreport
Volume24
Issue number11
DOIs
Publication statusPublished - 2013

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Acoustics
Equipment and Supplies
Prepulse Inhibition

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Cadenhead, K. S., Addington, J., Cannon, T. D., Cornblatt, B. A., de La Fuente-Sandoval, C., Mathalon, D. H., ... Solis-Vivanco, R. (2013). Between-site reliability of startle prepulse inhibition across two early psychosis consortia. Neuroreport, 24(11), 626-630. https://doi.org/10.1097/wnr.0b013e3283637845
Cadenhead, K.S. ; Addington, J. ; Cannon, T.D. ; Cornblatt, B.A. ; de La Fuente-Sandoval, C. ; Mathalon, D.H. ; Perkins, D.O. ; Seidman, L.J. ; Tsuang, M. ; Walker, E.F. ; Woods, S.W. ; Bachman, P. ; Belger, A. ; Carrion, R.E. ; Donkers, F.C.L. ; Duncan, E. ; Johannesen, J. ; Leon-Ortiz, P. ; Light, G. ; Mondragon, A. ; Niznikiewicz, M. ; Nunag, J. ; Roach, B.J. ; Solis-Vivanco, R. / Between-site reliability of startle prepulse inhibition across two early psychosis consortia. In: Neuroreport. 2013 ; Vol. 24, No. 11. pp. 626-630.
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abstract = "Prepulse inhibition (PPI) and reactivity of the acoustic startle response are widely used biobehavioral markers in psychopathology research. Previous studies have demonstrated that PPI and startle reactivity exhibit substantial within-site stability; however, between-site stability has not been established. In two separate consortia investigating biomarkers of early psychosis, traveling participants studies were carried out as a part of quality assurance procedures to assess the fidelity of data across sites. In the North American Prodromal Longitudinal Studies (NAPLS) consortium, eight normal participants traveled to each of the eight NAPLS sites and were tested twice at each site on the startle PPI paradigm. In preparation for a binational study, 10 healthy participants were assessed twice in both San Diego and Mexico City. Intraclass correlations between and within sites were significant for PPI and startle response parameters, confirming the reliability of startle measures across sites in both consortia. There were between-site differences in startle magnitude in the NAPLS study that did not appear to be related to methods or equipment. In planning multisite studies, it is essential to institute quality assurance procedures early and establish between-site reliability to assure comparable data across sites.",
author = "K.S. Cadenhead and J. Addington and T.D. Cannon and B.A. Cornblatt and {de La Fuente-Sandoval}, C. and D.H. Mathalon and D.O. Perkins and L.J. Seidman and M. Tsuang and E.F. Walker and S.W. Woods and P. Bachman and A. Belger and R.E. Carrion and F.C.L. Donkers and E. Duncan and J. Johannesen and P. Leon-Ortiz and G. Light and A. Mondragon and M. Niznikiewicz and J. Nunag and B.J. Roach and R. Solis-Vivanco",
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Cadenhead, KS, Addington, J, Cannon, TD, Cornblatt, BA, de La Fuente-Sandoval, C, Mathalon, DH, Perkins, DO, Seidman, LJ, Tsuang, M, Walker, EF, Woods, SW, Bachman, P, Belger, A, Carrion, RE, Donkers, FCL, Duncan, E, Johannesen, J, Leon-Ortiz, P, Light, G, Mondragon, A, Niznikiewicz, M, Nunag, J, Roach, BJ & Solis-Vivanco, R 2013, 'Between-site reliability of startle prepulse inhibition across two early psychosis consortia', Neuroreport, vol. 24, no. 11, pp. 626-630. https://doi.org/10.1097/wnr.0b013e3283637845

Between-site reliability of startle prepulse inhibition across two early psychosis consortia. / Cadenhead, K.S.; Addington, J.; Cannon, T.D.; Cornblatt, B.A.; de La Fuente-Sandoval, C.; Mathalon, D.H.; Perkins, D.O.; Seidman, L.J.; Tsuang, M.; Walker, E.F.; Woods, S.W.; Bachman, P.; Belger, A.; Carrion, R.E.; Donkers, F.C.L.; Duncan, E.; Johannesen, J.; Leon-Ortiz, P.; Light, G.; Mondragon, A.; Niznikiewicz, M.; Nunag, J.; Roach, B.J.; Solis-Vivanco, R.

In: Neuroreport, Vol. 24, No. 11, 2013, p. 626-630.

Research output: Contribution to journalArticleScientificpeer-review

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AU - Addington, J.

AU - Cannon, T.D.

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AU - de La Fuente-Sandoval, C.

AU - Mathalon, D.H.

AU - Perkins, D.O.

AU - Seidman, L.J.

AU - Tsuang, M.

AU - Walker, E.F.

AU - Woods, S.W.

AU - Bachman, P.

AU - Belger, A.

AU - Carrion, R.E.

AU - Donkers, F.C.L.

AU - Duncan, E.

AU - Johannesen, J.

AU - Leon-Ortiz, P.

AU - Light, G.

AU - Mondragon, A.

AU - Niznikiewicz, M.

AU - Nunag, J.

AU - Roach, B.J.

AU - Solis-Vivanco, R.

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DO - 10.1097/wnr.0b013e3283637845

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SN - 0959-4965

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Cadenhead KS, Addington J, Cannon TD, Cornblatt BA, de La Fuente-Sandoval C, Mathalon DH et al. Between-site reliability of startle prepulse inhibition across two early psychosis consortia. Neuroreport. 2013;24(11):626-630. https://doi.org/10.1097/wnr.0b013e3283637845