Chemotherapy-induced peripheral neuropathy and impact on quality of life 6 months after treatment with chemotherapy

A.J.M. Beijers, F. Mols, W. Dercksen, C. Driessen, G. Vreugdenhil

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Background:
Chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting toxicity of cytostatics. With improved survival among cancer patients, CIPN may have a major impact on quality of life (QoL) of cancer survivors.
Objective:
To determine the occurrence of CIPN induced by oxaliplatin and taxanes and its impact on QoL median 6 months after chemotherapy.
Methods:
All patients who received their last treatment with oxaliplatin or taxanes in 2 consecutive years in the Máxima Medical Centre, the Netherlands, were eligible for the study. Neurotoxicity and its effect on QoL was assessed with the recently developed Chemotherapy Induced Neurotoxicity Questionnaire (CINQ) and the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx) median 6 months after cessation of therapy.
Results:
Of the 58 eligible patients, 43 (74.1%) completed the questionnaire. After a median follow-up of 6.5 months after cessation of therapy, most of the patients experienced neurotoxicity in the upper and lower extremities (78.8% and 89.7%, respectively). Overall, the most-reported complaints included numbness and tingling in hands as well as feet, suffering from cold feet, and trouble distinguishing objects in the hands. Housekeeping difficulties were reported in 12.8% of patients, and 20.5% of patients became more dependent on others because of the neurotoxicity. Overall, QoL was negatively affected by the impact of CIPN in 48.6% of patients.
Limitations:
Due to the small sample size selection bias cannot be ruled out and no data about CIPN during treatment were available. Conclusions After a median follow-up of 6.5 months after cessation of therapy with oxaliplatin or taxanes, CIPN is common and leads to impairment in patient QoL. More research is needed to assess the impact of neurotoxicity on QoL.
Conclusions:
After a median follow-up of 6.5 months after cessation of therapy with oxaliplatin or taxanes, CIPN is common and leads to impairment in patient QoL. More research is needed to assess the impact of neurotoxicity on QoL.
KEYWORDS: cancer; chemotherapy; chemotherapy-induced peripheral neuropathy; neurotoxicity; oncology; quality of life
Original languageEnglish
Pages (from-to)401-406
JournalThe Journal of Community and Supportive Oncology
Volume12
Issue number11
DOIs
Publication statusPublished - 2014

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Peripheral Nervous System Diseases
Neoplasms
Housekeeping
Hypesthesia
Selection Bias
Netherlands
Survivors

Cite this

@article{1defa1bcfb0249e5b85f59527d15c200,
title = "Chemotherapy-induced peripheral neuropathy and impact on quality of life 6 months after treatment with chemotherapy",
abstract = "Background:Chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting toxicity of cytostatics. With improved survival among cancer patients, CIPN may have a major impact on quality of life (QoL) of cancer survivors.Objective:To determine the occurrence of CIPN induced by oxaliplatin and taxanes and its impact on QoL median 6 months after chemotherapy.Methods:All patients who received their last treatment with oxaliplatin or taxanes in 2 consecutive years in the M{\'a}xima Medical Centre, the Netherlands, were eligible for the study. Neurotoxicity and its effect on QoL was assessed with the recently developed Chemotherapy Induced Neurotoxicity Questionnaire (CINQ) and the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx) median 6 months after cessation of therapy.Results:Of the 58 eligible patients, 43 (74.1{\%}) completed the questionnaire. After a median follow-up of 6.5 months after cessation of therapy, most of the patients experienced neurotoxicity in the upper and lower extremities (78.8{\%} and 89.7{\%}, respectively). Overall, the most-reported complaints included numbness and tingling in hands as well as feet, suffering from cold feet, and trouble distinguishing objects in the hands. Housekeeping difficulties were reported in 12.8{\%} of patients, and 20.5{\%} of patients became more dependent on others because of the neurotoxicity. Overall, QoL was negatively affected by the impact of CIPN in 48.6{\%} of patients.Limitations:Due to the small sample size selection bias cannot be ruled out and no data about CIPN during treatment were available. Conclusions After a median follow-up of 6.5 months after cessation of therapy with oxaliplatin or taxanes, CIPN is common and leads to impairment in patient QoL. More research is needed to assess the impact of neurotoxicity on QoL.Conclusions:After a median follow-up of 6.5 months after cessation of therapy with oxaliplatin or taxanes, CIPN is common and leads to impairment in patient QoL. More research is needed to assess the impact of neurotoxicity on QoL.KEYWORDS: cancer; chemotherapy; chemotherapy-induced peripheral neuropathy; neurotoxicity; oncology; quality of life",
author = "A.J.M. Beijers and F. Mols and W. Dercksen and C. Driessen and G. Vreugdenhil",
year = "2014",
doi = "10.12788/jcso.0086",
language = "English",
volume = "12",
pages = "401--406",
journal = "The Journal of Community and Supportive Oncology",
issn = "2330-7749",
publisher = "Frontline Medical Communications",
number = "11",

}

Chemotherapy-induced peripheral neuropathy and impact on quality of life 6 months after treatment with chemotherapy. / Beijers, A.J.M.; Mols, F.; Dercksen, W.; Driessen, C.; Vreugdenhil, G.

In: The Journal of Community and Supportive Oncology, Vol. 12, No. 11, 2014, p. 401-406.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Chemotherapy-induced peripheral neuropathy and impact on quality of life 6 months after treatment with chemotherapy

AU - Beijers, A.J.M.

AU - Mols, F.

AU - Dercksen, W.

AU - Driessen, C.

AU - Vreugdenhil, G.

PY - 2014

Y1 - 2014

N2 - Background:Chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting toxicity of cytostatics. With improved survival among cancer patients, CIPN may have a major impact on quality of life (QoL) of cancer survivors.Objective:To determine the occurrence of CIPN induced by oxaliplatin and taxanes and its impact on QoL median 6 months after chemotherapy.Methods:All patients who received their last treatment with oxaliplatin or taxanes in 2 consecutive years in the Máxima Medical Centre, the Netherlands, were eligible for the study. Neurotoxicity and its effect on QoL was assessed with the recently developed Chemotherapy Induced Neurotoxicity Questionnaire (CINQ) and the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx) median 6 months after cessation of therapy.Results:Of the 58 eligible patients, 43 (74.1%) completed the questionnaire. After a median follow-up of 6.5 months after cessation of therapy, most of the patients experienced neurotoxicity in the upper and lower extremities (78.8% and 89.7%, respectively). Overall, the most-reported complaints included numbness and tingling in hands as well as feet, suffering from cold feet, and trouble distinguishing objects in the hands. Housekeeping difficulties were reported in 12.8% of patients, and 20.5% of patients became more dependent on others because of the neurotoxicity. Overall, QoL was negatively affected by the impact of CIPN in 48.6% of patients.Limitations:Due to the small sample size selection bias cannot be ruled out and no data about CIPN during treatment were available. Conclusions After a median follow-up of 6.5 months after cessation of therapy with oxaliplatin or taxanes, CIPN is common and leads to impairment in patient QoL. More research is needed to assess the impact of neurotoxicity on QoL.Conclusions:After a median follow-up of 6.5 months after cessation of therapy with oxaliplatin or taxanes, CIPN is common and leads to impairment in patient QoL. More research is needed to assess the impact of neurotoxicity on QoL.KEYWORDS: cancer; chemotherapy; chemotherapy-induced peripheral neuropathy; neurotoxicity; oncology; quality of life

AB - Background:Chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting toxicity of cytostatics. With improved survival among cancer patients, CIPN may have a major impact on quality of life (QoL) of cancer survivors.Objective:To determine the occurrence of CIPN induced by oxaliplatin and taxanes and its impact on QoL median 6 months after chemotherapy.Methods:All patients who received their last treatment with oxaliplatin or taxanes in 2 consecutive years in the Máxima Medical Centre, the Netherlands, were eligible for the study. Neurotoxicity and its effect on QoL was assessed with the recently developed Chemotherapy Induced Neurotoxicity Questionnaire (CINQ) and the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx) median 6 months after cessation of therapy.Results:Of the 58 eligible patients, 43 (74.1%) completed the questionnaire. After a median follow-up of 6.5 months after cessation of therapy, most of the patients experienced neurotoxicity in the upper and lower extremities (78.8% and 89.7%, respectively). Overall, the most-reported complaints included numbness and tingling in hands as well as feet, suffering from cold feet, and trouble distinguishing objects in the hands. Housekeeping difficulties were reported in 12.8% of patients, and 20.5% of patients became more dependent on others because of the neurotoxicity. Overall, QoL was negatively affected by the impact of CIPN in 48.6% of patients.Limitations:Due to the small sample size selection bias cannot be ruled out and no data about CIPN during treatment were available. Conclusions After a median follow-up of 6.5 months after cessation of therapy with oxaliplatin or taxanes, CIPN is common and leads to impairment in patient QoL. More research is needed to assess the impact of neurotoxicity on QoL.Conclusions:After a median follow-up of 6.5 months after cessation of therapy with oxaliplatin or taxanes, CIPN is common and leads to impairment in patient QoL. More research is needed to assess the impact of neurotoxicity on QoL.KEYWORDS: cancer; chemotherapy; chemotherapy-induced peripheral neuropathy; neurotoxicity; oncology; quality of life

U2 - 10.12788/jcso.0086

DO - 10.12788/jcso.0086

M3 - Article

VL - 12

SP - 401

EP - 406

JO - The Journal of Community and Supportive Oncology

JF - The Journal of Community and Supportive Oncology

SN - 2330-7749

IS - 11

ER -