Clinical outcomes of preterm infants while using automated controllers during standard care: comparison of cohorts with different automated titration strategies

Hylke H Salverda, Dianthe M L Beelen, Sophie J E Cramer, Steffen C Pauws, Nicoline Schalij-Delfos, Arjan B Te Pas

    Research output: Contribution to journalArticleScientificpeer-review

    4 Citations (Scopus)

    Abstract

    Objective To compare short-term clinical outcome after using two different automated oxygen controllers (OxyGenie and CLiO 2). Design Propensity score-matched retrospective observational study. Setting Tertiary-level neonatal unit in the Netherlands. Patients Preterm infants (OxyGenie n=121, CLiO 2 n=121) born between 24+0-29+6 weeks of gestation. Median (IQR) gestational age in the OxyGenie cohort was 28+3 (26+3.5-29+0) vs 27+5 (26+5-28+3) in the CLiO 2 cohort, respectively 42% and 46% of infants were male and mean (SD) birth weight was 1034 (266) g vs 1022 (242) g. Interventions Inspired oxygen was titrated by OxyGenie (SLE6000) or CLiO 2 (AVEA) during respiratory support. Main outcome measures Mortality, retinopathy of prematurity (ROP), bronchopulmonary dysplasia and necrotising enterocolitis. Results Fewer infants in the OxyGenie group received laser coagulation for ROP (1 infant vs 10; risk ratio 0.1 (95% CI 0.0 to 0.7); p=0.008), and infants stayed shorter in the neonatal intensive care unit (NICU) (28 (95% CI 15 to 42) vs 40 (95% CI 25 to 61) days; median difference 13.5 days (95% CI 8.5 to 19.5); p<0.001). Infants in the OxyGenie group had fewer days on continuous positive airway pressure (8.4 (95% CI 4.8 to 19.8) days vs 16.7 (95% CI 6.3 to 31.1); p<0.001) and a significantly shorter days on invasive ventilation (0 (95% CI 0 to 4.2) days vs 2.1 (95% CI 0 to 8.4); p=0.012). There were no statistically significant differences in all other morbidities. Conclusions In this propensity score-matched retrospective study, the OxyGenie epoch was associated with less morbidity when compared with the CLiO 2 epoch. There were significantly fewer infants that received treatment for ROP, received less intensive respiratory support and, although there were more supplemental oxygen days, the duration of stay in the NICU was shorter. A larger study will have to replicate these findings.

    Original languageEnglish
    Pages (from-to)26-30
    Number of pages5
    JournalArchives of Disease in Childhood. Fetal and Neonatal Edition
    Volume108
    Issue number1
    DOIs
    Publication statusPublished - 16 May 2022

    Keywords

    • Neonatology
    • Intensive Care Units, Neonatal
    • Ophthalmology
    • Respiratory
    • Episodes
    • Hemorrhage
    • Neonatal
    • Retinopathy
    • Inspired Oxygen

    Fingerprint

    Dive into the research topics of 'Clinical outcomes of preterm infants while using automated controllers during standard care: comparison of cohorts with different automated titration strategies'. Together they form a unique fingerprint.

    Cite this