CNTNAP2 and Language Processing in Healthy Individuals as Measured with ERPs

Miriam Kos; Danielle van den Brink; Tineke M. Snijders; Mark Rijpkema; Barbara Franke; Guillen Fernandez; Peter Hagoort

doi:10.1371/journal.pone.0046995

CNTNAP2 and Language Processing in Healthy Individuals as Measured with ERPs

Miriam Kos^*, Danielle van den Brink, Tineke M. Snijders, Mark Rijpkema, Barbara Franke, Guillen Fernandez, Peter Hagoort

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

The genetic FOXP2-CNTNAP2 pathway has been shown to be involved in the language capacity. We investigated whether a common variant of CNTNAP2 (rs7794745) is relevant for syntactic and semantic processing in the general population by using a visual sentence processing paradigm while recording ERPs in 49 healthy adults. While both AA homozygotes and T-carriers showed a standard N400 effect to semantic anomalies, the response to subject-verb agreement violations differed across genotype groups. T-carriers displayed an anterior negativity preceding the P600 effect, whereas for the AA group only a P600 effect was observed. These results provide another piece of evidence that the neuronal architecture of the human faculty of language is shaped differently by effects that are genetically determined.

Original language	English
Article number	46995
Number of pages	8
Journal	PLOS ONE
Volume	7
Issue number	10
DOIs	https://doi.org/10.1371/journal.pone.0046995
Publication status	Published - 24 Oct 2012
Externally published	Yes

Keywords

BRAIN POTENTIALS
SENTENCE COMPREHENSION
INHERITED SPEECH
FOXP2 GENE
DISORDER
SYNTAX
N400
INTEGRATION
EXPRESSION
SEMANTICS

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title = "CNTNAP2 and Language Processing in Healthy Individuals as Measured with ERPs",

abstract = "The genetic FOXP2-CNTNAP2 pathway has been shown to be involved in the language capacity. We investigated whether a common variant of CNTNAP2 (rs7794745) is relevant for syntactic and semantic processing in the general population by using a visual sentence processing paradigm while recording ERPs in 49 healthy adults. While both AA homozygotes and T-carriers showed a standard N400 effect to semantic anomalies, the response to subject-verb agreement violations differed across genotype groups. T-carriers displayed an anterior negativity preceding the P600 effect, whereas for the AA group only a P600 effect was observed. These results provide another piece of evidence that the neuronal architecture of the human faculty of language is shaped differently by effects that are genetically determined.",

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AU - Kos, Miriam

AU - van den Brink, Danielle

AU - Snijders, Tineke M.

AU - Rijpkema, Mark

AU - Franke, Barbara

AU - Fernandez, Guillen

AU - Hagoort, Peter

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AB - The genetic FOXP2-CNTNAP2 pathway has been shown to be involved in the language capacity. We investigated whether a common variant of CNTNAP2 (rs7794745) is relevant for syntactic and semantic processing in the general population by using a visual sentence processing paradigm while recording ERPs in 49 healthy adults. While both AA homozygotes and T-carriers showed a standard N400 effect to semantic anomalies, the response to subject-verb agreement violations differed across genotype groups. T-carriers displayed an anterior negativity preceding the P600 effect, whereas for the AA group only a P600 effect was observed. These results provide another piece of evidence that the neuronal architecture of the human faculty of language is shaped differently by effects that are genetically determined.

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KW - SENTENCE COMPREHENSION

KW - INHERITED SPEECH

KW - FOXP2 GENE

KW - DISORDER

KW - SYNTAX

KW - N400

KW - INTEGRATION

KW - EXPRESSION

KW - SEMANTICS

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ER -

CNTNAP2 and Language Processing in Healthy Individuals as Measured with ERPs

Abstract

Keywords

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