Coffee consumption after myocardial infarction and risk of cardiovascular mortality: a prospective analysis in the Alpha Omega Cohort

Laura H Van Dongen, Famke Jm Mölenberg, S.S. Soedamah-Muthu, Daan Kromhout, Johanna M Geleijnse

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Background:
Consumption of coffee, one of the most popular beverages around the world, has been associated with a lower risk of cardiovascular and all-cause mortality in population-based studies. However, little is known about these associations in patient populations.
Objective:
This prospective study aimed to examine the consumption of caffeinated and decaffeinated coffee in relation to cardiovascular disease (CVD) mortality, ischemic heart disease (IHD) mortality, and all-cause mortality in patients with a prior myocardial infarction (MI).
Design:
We included 4365 Dutch patients from the Alpha Omega Cohort who were aged 60–80 y (21% female) and had experienced an MI ,10 y before study enrollment. At baseline (2002–2006), dietary data including coffee consumption over the past month was collected with a 203-item validated food-frequency questionnaire. Causes of death were monitored until 1 January 2013. HRs for mortality in categories of coffee consumption were obtained from multivariable Cox proportional hazard models, adjusting for lifestyle and dietary factors. Results:
Most patients (96%) drank coffee, and the median total coffee intake was 375 mL/d (w3 cups/d). During a median followup of 7.1 y, a total of 945 deaths occurred, including 396 CVDrelated and 266 IHD-related deaths. Coffee consumption was inversely associated with CVD mortality, with HRs of 0.69 (95% CI: 0.54, 0.89) for .2–4 cups/d and 0.72 (0.55, 0.95) for .4 cups/d, compared with 0–2 cups/d. Corresponding HRs were 0.77 (95% CI: 0.57, 1.05) and 0.68 (95% CI: 0.48, 0.95) for IHD mortality and 0.84 (95% CI: 0.71, 1.00) and 0.82 (95% CI: 0.68, 0.98) for all-cause mortality, respectively. Similar associations were found for decaffeinated coffee and for coffee with additives.
Conclusion:
Drinking coffee, either caffeinated or decaffeinated, may lower the risk of CVD and IHD mortality in patients with a prior MI
Original languageEnglish
Pages (from-to)1113-1120
JournalAmerican Journal of Clinical Nutrition
Volume106
Issue number4
DOIs
Publication statusPublished - 1 Oct 2017

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