Cognitive functioning in patients with non-functioning pituitary adenoma before and after endoscopic transsphenoidal resection

Individual and group results

Elke Butterbrod, Karin Gehring, Eduard Voormolen, Paul Depauw, Willy-Anne Nieuwlaat, Geert-Jan Rutten, Margriet Sitskoorn

Research output: Contribution to conferenceAbstractOther research output

Abstract

Background:

Cognitive dysfunction in patients with non-functioning pituitary adenoma (NFPA) primarily pertains to memory and executive functioning. Current literature is comprised of studies employing dissimilar methodological approaches and there is little prospective research using standardized cognitive function measures before and after surgical tumor resection. This study investigated group and individual cognitive status and change over time.

Material and Methods:

Forty-five patients underwent neuropsychological assessment one day before and 3 months after transsphenoidal surgery. A computerized neuropsychological test-battery (CNSVS) was used to measure cognitive functioning on 7 domains: Verbal Memory, Visual Memory, Processing Speed, Psychomotor Speed, Reaction Time, Complex Attention and Cognitive Flexibility. Analyses of cognitive status and change were conducted on group and individual level. Associations of preoperative performance with tumor expansion, categorized according to Wilson-Hardy and Knosp classifications, and hormonal deficiency were investigated in exploratory analyses.

Results:

As a group, patients scored significantly lower than healthy controls on all domains except Visual memory before as well as three months after surgery. Fifty-six percent of patients showed impairment (z-score ≤ - 1.5) on at least one domain before surgery and 63% after surgery. Patients showed no significant change over time as a group, but we found almost equal proportions of patients showing reliable improvement, decline, and stable performance. Degree of suprasellar extension and cavernous sinus invasion did not show a significant relationship with pre-operative cognitive status. Hormonal deficiency was related to Verbal Memory performance.

Conclusion:

Over half of patients showed cognitive impairment before as well as after surgery and dysfunction involved processing and psychomotor speed domains in addition to memory and executive functioning. Differential patterns of reliable cognitive change over time in individual patients were masked in group-level analyses. Future studies with larger samples sizes should address predictors of peri-operative cognitive status and the varied post-surgical course.
Original languageEnglish
PagesP05 Other Tumor - Clinical Aspects
Publication statusPublished - 2018
Event13th Meeting of the European Association of Neuro-Oncology (EANO) - Stockholm, Sweden
Duration: 10 Oct 2018 → …

Conference

Conference13th Meeting of the European Association of Neuro-Oncology (EANO)
CountrySweden
CityStockholm
Period10/10/18 → …

Fingerprint

Cavernous Sinus
Neoplasms
Cognitive Dysfunction

Cite this

Butterbrod, E., Gehring, K., Voormolen, E., Depauw, P., Nieuwlaat, W-A., Rutten, G-J., & Sitskoorn, M. (2018). Cognitive functioning in patients with non-functioning pituitary adenoma before and after endoscopic transsphenoidal resection: Individual and group results. P05 Other Tumor - Clinical Aspects. Abstract from 13th Meeting of the European Association of Neuro-Oncology (EANO), Stockholm, Sweden.
Butterbrod, Elke ; Gehring, Karin ; Voormolen, Eduard ; Depauw, Paul ; Nieuwlaat, Willy-Anne ; Rutten, Geert-Jan ; Sitskoorn, Margriet. / Cognitive functioning in patients with non-functioning pituitary adenoma before and after endoscopic transsphenoidal resection : Individual and group results. Abstract from 13th Meeting of the European Association of Neuro-Oncology (EANO), Stockholm, Sweden.
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title = "Cognitive functioning in patients with non-functioning pituitary adenoma before and after endoscopic transsphenoidal resection: Individual and group results",
abstract = "Background: Cognitive dysfunction in patients with non-functioning pituitary adenoma (NFPA) primarily pertains to memory and executive functioning. Current literature is comprised of studies employing dissimilar methodological approaches and there is little prospective research using standardized cognitive function measures before and after surgical tumor resection. This study investigated group and individual cognitive status and change over time.Material and Methods: Forty-five patients underwent neuropsychological assessment one day before and 3 months after transsphenoidal surgery. A computerized neuropsychological test-battery (CNSVS) was used to measure cognitive functioning on 7 domains: Verbal Memory, Visual Memory, Processing Speed, Psychomotor Speed, Reaction Time, Complex Attention and Cognitive Flexibility. Analyses of cognitive status and change were conducted on group and individual level. Associations of preoperative performance with tumor expansion, categorized according to Wilson-Hardy and Knosp classifications, and hormonal deficiency were investigated in exploratory analyses.Results: As a group, patients scored significantly lower than healthy controls on all domains except Visual memory before as well as three months after surgery. Fifty-six percent of patients showed impairment (z-score ≤ - 1.5) on at least one domain before surgery and 63{\%} after surgery. Patients showed no significant change over time as a group, but we found almost equal proportions of patients showing reliable improvement, decline, and stable performance. Degree of suprasellar extension and cavernous sinus invasion did not show a significant relationship with pre-operative cognitive status. Hormonal deficiency was related to Verbal Memory performance.Conclusion: Over half of patients showed cognitive impairment before as well as after surgery and dysfunction involved processing and psychomotor speed domains in addition to memory and executive functioning. Differential patterns of reliable cognitive change over time in individual patients were masked in group-level analyses. Future studies with larger samples sizes should address predictors of peri-operative cognitive status and the varied post-surgical course.",
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Butterbrod, E, Gehring, K, Voormolen, E, Depauw, P, Nieuwlaat, W-A, Rutten, G-J & Sitskoorn, M 2018, 'Cognitive functioning in patients with non-functioning pituitary adenoma before and after endoscopic transsphenoidal resection: Individual and group results' 13th Meeting of the European Association of Neuro-Oncology (EANO), Stockholm, Sweden, 10/10/18, pp. P05 Other Tumor - Clinical Aspects.

Cognitive functioning in patients with non-functioning pituitary adenoma before and after endoscopic transsphenoidal resection : Individual and group results. / Butterbrod, Elke; Gehring, Karin; Voormolen, Eduard; Depauw, Paul; Nieuwlaat, Willy-Anne; Rutten, Geert-Jan; Sitskoorn, Margriet.

2018. P05 Other Tumor - Clinical Aspects Abstract from 13th Meeting of the European Association of Neuro-Oncology (EANO), Stockholm, Sweden.

Research output: Contribution to conferenceAbstractOther research output

TY - CONF

T1 - Cognitive functioning in patients with non-functioning pituitary adenoma before and after endoscopic transsphenoidal resection

T2 - Individual and group results

AU - Butterbrod, Elke

AU - Gehring, Karin

AU - Voormolen, Eduard

AU - Depauw, Paul

AU - Nieuwlaat, Willy-Anne

AU - Rutten, Geert-Jan

AU - Sitskoorn, Margriet

PY - 2018

Y1 - 2018

N2 - Background: Cognitive dysfunction in patients with non-functioning pituitary adenoma (NFPA) primarily pertains to memory and executive functioning. Current literature is comprised of studies employing dissimilar methodological approaches and there is little prospective research using standardized cognitive function measures before and after surgical tumor resection. This study investigated group and individual cognitive status and change over time.Material and Methods: Forty-five patients underwent neuropsychological assessment one day before and 3 months after transsphenoidal surgery. A computerized neuropsychological test-battery (CNSVS) was used to measure cognitive functioning on 7 domains: Verbal Memory, Visual Memory, Processing Speed, Psychomotor Speed, Reaction Time, Complex Attention and Cognitive Flexibility. Analyses of cognitive status and change were conducted on group and individual level. Associations of preoperative performance with tumor expansion, categorized according to Wilson-Hardy and Knosp classifications, and hormonal deficiency were investigated in exploratory analyses.Results: As a group, patients scored significantly lower than healthy controls on all domains except Visual memory before as well as three months after surgery. Fifty-six percent of patients showed impairment (z-score ≤ - 1.5) on at least one domain before surgery and 63% after surgery. Patients showed no significant change over time as a group, but we found almost equal proportions of patients showing reliable improvement, decline, and stable performance. Degree of suprasellar extension and cavernous sinus invasion did not show a significant relationship with pre-operative cognitive status. Hormonal deficiency was related to Verbal Memory performance.Conclusion: Over half of patients showed cognitive impairment before as well as after surgery and dysfunction involved processing and psychomotor speed domains in addition to memory and executive functioning. Differential patterns of reliable cognitive change over time in individual patients were masked in group-level analyses. Future studies with larger samples sizes should address predictors of peri-operative cognitive status and the varied post-surgical course.

AB - Background: Cognitive dysfunction in patients with non-functioning pituitary adenoma (NFPA) primarily pertains to memory and executive functioning. Current literature is comprised of studies employing dissimilar methodological approaches and there is little prospective research using standardized cognitive function measures before and after surgical tumor resection. This study investigated group and individual cognitive status and change over time.Material and Methods: Forty-five patients underwent neuropsychological assessment one day before and 3 months after transsphenoidal surgery. A computerized neuropsychological test-battery (CNSVS) was used to measure cognitive functioning on 7 domains: Verbal Memory, Visual Memory, Processing Speed, Psychomotor Speed, Reaction Time, Complex Attention and Cognitive Flexibility. Analyses of cognitive status and change were conducted on group and individual level. Associations of preoperative performance with tumor expansion, categorized according to Wilson-Hardy and Knosp classifications, and hormonal deficiency were investigated in exploratory analyses.Results: As a group, patients scored significantly lower than healthy controls on all domains except Visual memory before as well as three months after surgery. Fifty-six percent of patients showed impairment (z-score ≤ - 1.5) on at least one domain before surgery and 63% after surgery. Patients showed no significant change over time as a group, but we found almost equal proportions of patients showing reliable improvement, decline, and stable performance. Degree of suprasellar extension and cavernous sinus invasion did not show a significant relationship with pre-operative cognitive status. Hormonal deficiency was related to Verbal Memory performance.Conclusion: Over half of patients showed cognitive impairment before as well as after surgery and dysfunction involved processing and psychomotor speed domains in addition to memory and executive functioning. Differential patterns of reliable cognitive change over time in individual patients were masked in group-level analyses. Future studies with larger samples sizes should address predictors of peri-operative cognitive status and the varied post-surgical course.

M3 - Abstract

SP - P05 Other Tumor - Clinical Aspects

ER -

Butterbrod E, Gehring K, Voormolen E, Depauw P, Nieuwlaat W-A, Rutten G-J et al. Cognitive functioning in patients with non-functioning pituitary adenoma before and after endoscopic transsphenoidal resection: Individual and group results. 2018. Abstract from 13th Meeting of the European Association of Neuro-Oncology (EANO), Stockholm, Sweden.