Comorbidity of autoimmune thyroid disorders and psychiatric disorders during the postpartum period

A Danish nationwide register based cohort study

V. Bergink, V.J.M. Pop, P.R. Nielsen, E. Agerbo, T. Munk-Olsen, X. Liu

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Background. 

The postpartum period is well-known risk period for the first onset of autoimmune thyroid disorders (AITDs) as well as first onset of psychiatric disorders. These two disorders are some of the most prevalent medical conditions postpartum, often misdiagnosed and disabling if left untreated. Our study was designed to explore the possible bidirectional association between AITDs and psychiatric disorders during the postpartum period.

Methods. 

A population-based cohort study through linkage of Danish national registers, which comprised 312 779 women who gave birth to their first child during 1997-2010. We conducted Poisson regression analysis to estimate the incidence rate ratio (IRR) of psychiatric disorders among women with first-onset AITDs, the IRR of AITDs among women with first-onset psychiatric disorders as well as the overlap between these disorders using a comorbidity index.

Results. 

Women with first-onset AITDs postpartum were more likely to have first-onset psychiatric disorders than women who did not have postpartum AITDs (IRR = 1.88, 95% confidence interval (CI): 1.25-2.81). Women with first-onset postpartum psychiatric disorders had a higher risk of AITDs than women with no psychiatric disorders (IRR = 2.16, 95% CI: 1.45-3.20). The comorbidity index 2 years after delivery was 2.26 (95% CI: 1.61-2.90), indicating a comorbidity between first-onset AITDs and psychiatric disorders.

Conclusions. 

First-onset AITDs and psychiatric disorders co-occur in the postpartum period, which has relevance to further studies on the etiologies of these disorders and why childbirth in particular triggers the onset.

Original languageEnglish
Pages (from-to)1291-1298
JournalPsychological Medicine
Volume48
Issue number8
DOIs
Publication statusPublished - 2018

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Comorbidity
Incidence
Confidence Intervals
Diagnostic Errors

Keywords

  • Anxiety
  • BIPOLAR DISORDER
  • DISEASE
  • DYSFUNCTION
  • MECHANISMS
  • PERINATAL DEPRESSION
  • POPULATION
  • PREGNANCY
  • PREVALENCE
  • PSYCHOSIS
  • depression
  • postpartum
  • psychosis
  • thyroid
  • thyroiditis

Cite this

@article{3f19c8a0d0414634a92f2825ec9f871a,
title = "Comorbidity of autoimmune thyroid disorders and psychiatric disorders during the postpartum period: A Danish nationwide register based cohort study",
abstract = "Background. The postpartum period is well-known risk period for the first onset of autoimmune thyroid disorders (AITDs) as well as first onset of psychiatric disorders. These two disorders are some of the most prevalent medical conditions postpartum, often misdiagnosed and disabling if left untreated. Our study was designed to explore the possible bidirectional association between AITDs and psychiatric disorders during the postpartum period.Methods. A population-based cohort study through linkage of Danish national registers, which comprised 312 779 women who gave birth to their first child during 1997-2010. We conducted Poisson regression analysis to estimate the incidence rate ratio (IRR) of psychiatric disorders among women with first-onset AITDs, the IRR of AITDs among women with first-onset psychiatric disorders as well as the overlap between these disorders using a comorbidity index.Results. Women with first-onset AITDs postpartum were more likely to have first-onset psychiatric disorders than women who did not have postpartum AITDs (IRR = 1.88, 95{\%} confidence interval (CI): 1.25-2.81). Women with first-onset postpartum psychiatric disorders had a higher risk of AITDs than women with no psychiatric disorders (IRR = 2.16, 95{\%} CI: 1.45-3.20). The comorbidity index 2 years after delivery was 2.26 (95{\%} CI: 1.61-2.90), indicating a comorbidity between first-onset AITDs and psychiatric disorders.Conclusions. First-onset AITDs and psychiatric disorders co-occur in the postpartum period, which has relevance to further studies on the etiologies of these disorders and why childbirth in particular triggers the onset.",
keywords = "Anxiety, BIPOLAR DISORDER, DISEASE, DYSFUNCTION, MECHANISMS, PERINATAL DEPRESSION, POPULATION, PREGNANCY, PREVALENCE, PSYCHOSIS, depression, postpartum, psychosis, thyroid, thyroiditis",
author = "V. Bergink and V.J.M. Pop and P.R. Nielsen and E. Agerbo and T. Munk-Olsen and X. Liu",
year = "2018",
doi = "10.1017/S0033291717002732",
language = "English",
volume = "48",
pages = "1291--1298",
journal = "Psychological Medicine",
issn = "0033-2917",
publisher = "CAMBRIDGE UNIV PRESS",
number = "8",

}

Comorbidity of autoimmune thyroid disorders and psychiatric disorders during the postpartum period : A Danish nationwide register based cohort study. / Bergink, V.; Pop, V.J.M.; Nielsen, P.R.; Agerbo, E.; Munk-Olsen, T.; Liu, X.

In: Psychological Medicine, Vol. 48, No. 8, 2018, p. 1291-1298.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Comorbidity of autoimmune thyroid disorders and psychiatric disorders during the postpartum period

T2 - A Danish nationwide register based cohort study

AU - Bergink, V.

AU - Pop, V.J.M.

AU - Nielsen, P.R.

AU - Agerbo, E.

AU - Munk-Olsen, T.

AU - Liu, X.

PY - 2018

Y1 - 2018

N2 - Background. The postpartum period is well-known risk period for the first onset of autoimmune thyroid disorders (AITDs) as well as first onset of psychiatric disorders. These two disorders are some of the most prevalent medical conditions postpartum, often misdiagnosed and disabling if left untreated. Our study was designed to explore the possible bidirectional association between AITDs and psychiatric disorders during the postpartum period.Methods. A population-based cohort study through linkage of Danish national registers, which comprised 312 779 women who gave birth to their first child during 1997-2010. We conducted Poisson regression analysis to estimate the incidence rate ratio (IRR) of psychiatric disorders among women with first-onset AITDs, the IRR of AITDs among women with first-onset psychiatric disorders as well as the overlap between these disorders using a comorbidity index.Results. Women with first-onset AITDs postpartum were more likely to have first-onset psychiatric disorders than women who did not have postpartum AITDs (IRR = 1.88, 95% confidence interval (CI): 1.25-2.81). Women with first-onset postpartum psychiatric disorders had a higher risk of AITDs than women with no psychiatric disorders (IRR = 2.16, 95% CI: 1.45-3.20). The comorbidity index 2 years after delivery was 2.26 (95% CI: 1.61-2.90), indicating a comorbidity between first-onset AITDs and psychiatric disorders.Conclusions. First-onset AITDs and psychiatric disorders co-occur in the postpartum period, which has relevance to further studies on the etiologies of these disorders and why childbirth in particular triggers the onset.

AB - Background. The postpartum period is well-known risk period for the first onset of autoimmune thyroid disorders (AITDs) as well as first onset of psychiatric disorders. These two disorders are some of the most prevalent medical conditions postpartum, often misdiagnosed and disabling if left untreated. Our study was designed to explore the possible bidirectional association between AITDs and psychiatric disorders during the postpartum period.Methods. A population-based cohort study through linkage of Danish national registers, which comprised 312 779 women who gave birth to their first child during 1997-2010. We conducted Poisson regression analysis to estimate the incidence rate ratio (IRR) of psychiatric disorders among women with first-onset AITDs, the IRR of AITDs among women with first-onset psychiatric disorders as well as the overlap between these disorders using a comorbidity index.Results. Women with first-onset AITDs postpartum were more likely to have first-onset psychiatric disorders than women who did not have postpartum AITDs (IRR = 1.88, 95% confidence interval (CI): 1.25-2.81). Women with first-onset postpartum psychiatric disorders had a higher risk of AITDs than women with no psychiatric disorders (IRR = 2.16, 95% CI: 1.45-3.20). The comorbidity index 2 years after delivery was 2.26 (95% CI: 1.61-2.90), indicating a comorbidity between first-onset AITDs and psychiatric disorders.Conclusions. First-onset AITDs and psychiatric disorders co-occur in the postpartum period, which has relevance to further studies on the etiologies of these disorders and why childbirth in particular triggers the onset.

KW - Anxiety

KW - BIPOLAR DISORDER

KW - DISEASE

KW - DYSFUNCTION

KW - MECHANISMS

KW - PERINATAL DEPRESSION

KW - POPULATION

KW - PREGNANCY

KW - PREVALENCE

KW - PSYCHOSIS

KW - depression

KW - postpartum

KW - psychosis

KW - thyroid

KW - thyroiditis

U2 - 10.1017/S0033291717002732

DO - 10.1017/S0033291717002732

M3 - Article

VL - 48

SP - 1291

EP - 1298

JO - Psychological Medicine

JF - Psychological Medicine

SN - 0033-2917

IS - 8

ER -