Comparison of two automated oxygen controllers in oxygen targeting in preterm infants during admission: an observational study

Hylke H. Salverda*, Janneke Dekker, Enrico Lopriore, Peter A. Dargaville, Steffen C. Pauws, Arjan B. te Pas

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

1 Citation (Scopus)


Objective To compare the effect of two different automated oxygen control devices on time preterm infants spent in different oxygen saturation (SpO 2) ranges during their entire stay in the neonatal intensive care unit (NICU). Design Retrospective cohort study of prospectively collected data. Setting Tertiary level neonatal unit in the Netherlands. Patients Preterm infants (OxyGenie 75 infants, CLiO 2 111 infants) born at 24-29 weeks' gestation receiving at least 72 hours of respiratory support between October 2015 and November 2020. Interventions Inspired oxygen concentration was titrated by the OxyGenie controller (SLE6000 ventilator) between February 2019 and November 2020 and the CLiO 2 controller (AVEA ventilator) between October 2015 and December 2018 as standard of care. Main outcome measures Time spent within SpO 2 target range (TR, 91-95% for either epoch) and other SpO 2 ranges. Results Time spent within the SpO 2 TR when receiving supplemental oxygen was higher during OxyGenie control (median 71.5 [IQR 64.6-77.0]% vs 51.3 [47.3-58.5]%, p<0.001). Infants under OxyGenie control spent less time in hypoxic and hyperoxic ranges (SpO 2 <80%: 0.7 [0.4-1.4]% vs 1.2 [0.7-2.3]%, p<0.001; SpO2>98%: 1.0 [0.5-2.4]% vs 4.0 [2.0-7.9]%, p<0.001). Both groups received a similar FiO 2 (29.5 [28.0-33.2]% vs 29.6 [27.7-32.1]%, p=not significant). Conclusions Oxygen saturation targeting was significantly different in the OxyGenie epoch in preterm infants, with less time in hypoxic and hyperoxic SpO 2 ranges during their stay in the NICU.

Original languageEnglish
Pages (from-to)394-399
Number of pages6
JournalArchives of Disease in Childhood. Fetal and Neonatal Edition
Issue number4
Early online date4 Jan 2023
Publication statusPublished - 1 Jul 2023


  • Neonatology
  • Respiratory Medicine
  • Inspired Oxygen
  • Saturation
  • Episodes


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