Correlation and Interchangeability of Venous and Capillary Blood Gases in Non-Critically Ill Neonates

Ratna N G B Tan, Steffen C Pauws, Evelyne van Loon, Vivanne E H J Smits, Enrico Lopriore, Arjan B Te Pas

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Background: Venous blood gas (VBG) is frequently used in the neonatal unit as alternative for capillary blood gas (CBG). However, studies reporting correlation are conflicting and data on interchangeability in neonates are lacking.

Objective: We investigated the correlation and interchangeability of the components between VBG and CBG in infants admitted to the neonatal intensive care unit.

Methods: In a prospective study in the neonatal unit in Leiden University Medical Center (Netherlands), simultaneously VBG and CBG were withdrawn in neonates when both venous puncture and intravenous access as blood gas monitoring was indicated. From each blood gas analysis, a Pearson correlation, intraclass correlation, and Bland-Altman analysis was performed. Clinically acceptable difference for each blood gas value was defined up-front by means of an absolute difference: pH ± 0.05; partial pressure of carbon dioxide (pCO2) (±0.67 kPa = 5 mmHg); partial pressure of oxygen (pO2) (±0.67 kPa = 5 mmHg); base excess ± 3 mmol/l; and bicarbonate (HCO3-) ± 3 mmol/l.

Results: In 93 patients [median gestational age 31 (IQR 29-34) weeks], 193 paired samples of VBG and CBG were collected. The Pearson correlation between VBG and CBG was very strong for pH (r = 0.79; P < 0.001), BE (r = 0.90; P < 0.001) and bicarbonate (r = 0.87; P < 0.001); strong for pCO2 (r = 0.68; P < 0.001); and moderate for pO2 (r = 0.31; P < 0.001). The percentage of the interchangeability within our acceptable absolute difference for pH was 88%, pCO2 72%, pO2 55%, BE 90%, and bicarbonate 94%.

Conclusion: VBG and CBG in neonates are well correlated and mostly interchangeable, except for pO2.

Original languageEnglish
Pages (from-to)89
JournalFrontiers in pediatrics
Volume6
DOIs
Publication statusPublished - 2018

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Gases
Newborn Infant
Partial Pressure
Neonatal Intensive Care Units
Netherlands
Gestational Age
Oxygen

Cite this

Tan, Ratna N G B ; Pauws, Steffen C ; van Loon, Evelyne ; Smits, Vivanne E H J ; Lopriore, Enrico ; Te Pas, Arjan B. / Correlation and Interchangeability of Venous and Capillary Blood Gases in Non-Critically Ill Neonates. In: Frontiers in pediatrics. 2018 ; Vol. 6. pp. 89.
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title = "Correlation and Interchangeability of Venous and Capillary Blood Gases in Non-Critically Ill Neonates",
abstract = "Background: Venous blood gas (VBG) is frequently used in the neonatal unit as alternative for capillary blood gas (CBG). However, studies reporting correlation are conflicting and data on interchangeability in neonates are lacking.Objective: We investigated the correlation and interchangeability of the components between VBG and CBG in infants admitted to the neonatal intensive care unit.Methods: In a prospective study in the neonatal unit in Leiden University Medical Center (Netherlands), simultaneously VBG and CBG were withdrawn in neonates when both venous puncture and intravenous access as blood gas monitoring was indicated. From each blood gas analysis, a Pearson correlation, intraclass correlation, and Bland-Altman analysis was performed. Clinically acceptable difference for each blood gas value was defined up-front by means of an absolute difference: pH ± 0.05; partial pressure of carbon dioxide (pCO2) (±0.67 kPa = 5 mmHg); partial pressure of oxygen (pO2) (±0.67 kPa = 5 mmHg); base excess ± 3 mmol/l; and bicarbonate (HCO3-) ± 3 mmol/l.Results: In 93 patients [median gestational age 31 (IQR 29-34) weeks], 193 paired samples of VBG and CBG were collected. The Pearson correlation between VBG and CBG was very strong for pH (r = 0.79; P < 0.001), BE (r = 0.90; P < 0.001) and bicarbonate (r = 0.87; P < 0.001); strong for pCO2 (r = 0.68; P < 0.001); and moderate for pO2 (r = 0.31; P < 0.001). The percentage of the interchangeability within our acceptable absolute difference for pH was 88{\%}, pCO2 72{\%}, pO2 55{\%}, BE 90{\%}, and bicarbonate 94{\%}.Conclusion: VBG and CBG in neonates are well correlated and mostly interchangeable, except for pO2.",
author = "Tan, {Ratna N G B} and Pauws, {Steffen C} and {van Loon}, Evelyne and Smits, {Vivanne E H J} and Enrico Lopriore and {Te Pas}, {Arjan B}",
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Correlation and Interchangeability of Venous and Capillary Blood Gases in Non-Critically Ill Neonates. / Tan, Ratna N G B; Pauws, Steffen C; van Loon, Evelyne; Smits, Vivanne E H J; Lopriore, Enrico; Te Pas, Arjan B.

In: Frontiers in pediatrics, Vol. 6, 2018, p. 89.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Correlation and Interchangeability of Venous and Capillary Blood Gases in Non-Critically Ill Neonates

AU - Tan, Ratna N G B

AU - Pauws, Steffen C

AU - van Loon, Evelyne

AU - Smits, Vivanne E H J

AU - Lopriore, Enrico

AU - Te Pas, Arjan B

PY - 2018

Y1 - 2018

N2 - Background: Venous blood gas (VBG) is frequently used in the neonatal unit as alternative for capillary blood gas (CBG). However, studies reporting correlation are conflicting and data on interchangeability in neonates are lacking.Objective: We investigated the correlation and interchangeability of the components between VBG and CBG in infants admitted to the neonatal intensive care unit.Methods: In a prospective study in the neonatal unit in Leiden University Medical Center (Netherlands), simultaneously VBG and CBG were withdrawn in neonates when both venous puncture and intravenous access as blood gas monitoring was indicated. From each blood gas analysis, a Pearson correlation, intraclass correlation, and Bland-Altman analysis was performed. Clinically acceptable difference for each blood gas value was defined up-front by means of an absolute difference: pH ± 0.05; partial pressure of carbon dioxide (pCO2) (±0.67 kPa = 5 mmHg); partial pressure of oxygen (pO2) (±0.67 kPa = 5 mmHg); base excess ± 3 mmol/l; and bicarbonate (HCO3-) ± 3 mmol/l.Results: In 93 patients [median gestational age 31 (IQR 29-34) weeks], 193 paired samples of VBG and CBG were collected. The Pearson correlation between VBG and CBG was very strong for pH (r = 0.79; P < 0.001), BE (r = 0.90; P < 0.001) and bicarbonate (r = 0.87; P < 0.001); strong for pCO2 (r = 0.68; P < 0.001); and moderate for pO2 (r = 0.31; P < 0.001). The percentage of the interchangeability within our acceptable absolute difference for pH was 88%, pCO2 72%, pO2 55%, BE 90%, and bicarbonate 94%.Conclusion: VBG and CBG in neonates are well correlated and mostly interchangeable, except for pO2.

AB - Background: Venous blood gas (VBG) is frequently used in the neonatal unit as alternative for capillary blood gas (CBG). However, studies reporting correlation are conflicting and data on interchangeability in neonates are lacking.Objective: We investigated the correlation and interchangeability of the components between VBG and CBG in infants admitted to the neonatal intensive care unit.Methods: In a prospective study in the neonatal unit in Leiden University Medical Center (Netherlands), simultaneously VBG and CBG were withdrawn in neonates when both venous puncture and intravenous access as blood gas monitoring was indicated. From each blood gas analysis, a Pearson correlation, intraclass correlation, and Bland-Altman analysis was performed. Clinically acceptable difference for each blood gas value was defined up-front by means of an absolute difference: pH ± 0.05; partial pressure of carbon dioxide (pCO2) (±0.67 kPa = 5 mmHg); partial pressure of oxygen (pO2) (±0.67 kPa = 5 mmHg); base excess ± 3 mmol/l; and bicarbonate (HCO3-) ± 3 mmol/l.Results: In 93 patients [median gestational age 31 (IQR 29-34) weeks], 193 paired samples of VBG and CBG were collected. The Pearson correlation between VBG and CBG was very strong for pH (r = 0.79; P < 0.001), BE (r = 0.90; P < 0.001) and bicarbonate (r = 0.87; P < 0.001); strong for pCO2 (r = 0.68; P < 0.001); and moderate for pO2 (r = 0.31; P < 0.001). The percentage of the interchangeability within our acceptable absolute difference for pH was 88%, pCO2 72%, pO2 55%, BE 90%, and bicarbonate 94%.Conclusion: VBG and CBG in neonates are well correlated and mostly interchangeable, except for pO2.

U2 - 10.3389/fped.2018.00089

DO - 10.3389/fped.2018.00089

M3 - Article

VL - 6

SP - 89

JO - Frontiers in pediatrics

JF - Frontiers in pediatrics

SN - 2296-2360

ER -