Declining antibody levels after hepatitis B vaccination in Down syndrome: A need for booster vaccination?

N.B. Eijsvoogel, M.I. Hollegien, L.A. Bok, A. Derksen-Lubsen, F. Dikken, A.C.A.P. Leenders, A. Pijning, E. Post, M. Wojciechowski, M. Hilbink, E. de Vries

Research output: Contribution to journalArticleScientificpeer-review

2 Citations (Scopus)

Abstract

We determined the anti-HBs titer in 227 children of all ages with Down syndrome (DS). Only 48.1% (95%CI: 35.1-61.3) of the DS children aged 7-10 years and 31.9% (95%CI: 22.1-43.6) of the DS children aged >10 years had a protective anti-HBs titer (≥10 IU/L). The geometric mean anti-HBs titer was significantly lower in the DS children; this suggests booster vaccination for HBV may be needed.
Original languageEnglish
Pages (from-to)1682-1685
JournalJournal of Medical Virology
Volume89
Issue number9
DOIs
Publication statusPublished - 2017

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