We determined the anti-HBs titer in 227 children of all ages with Down syndrome (DS). Only 48.1% (95%CI: 35.1-61.3) of the DS children aged 7-10 years and 31.9% (95%CI: 22.1-43.6) of the DS children aged >10 years had a protective anti-HBs titer (≥10 IU/L). The geometric mean anti-HBs titer was significantly lower in the DS children; this suggests booster vaccination for HBV may be needed.
Eijsvoogel, N. B., Hollegien, M. I., Bok, L. A., Derksen-Lubsen, A., Dikken, F., Leenders, A. C. A. P., Pijning, A., Post, E., Wojciechowski, M., Hilbink, M., & de Vries, E. (2017). Declining antibody levels after hepatitis B vaccination in Down syndrome: A need for booster vaccination? Journal of Medical Virology, 89(9), 1682-1685. https://doi.org/10.1002/jmv.24813