Declining antibody levels after hepatitis B vaccination in Down syndrome

A need for booster vaccination?

N.B. Eijsvoogel, M.I. Hollegien, L.A. Bok, A. Derksen-Lubsen, F. Dikken, A.C.A.P. Leenders, A. Pijning, E. Post, M. Wojciechowski, M. Hilbink, E. de Vries

Research output: Contribution to journalArticleScientificpeer-review

Abstract

We determined the anti-HBs titer in 227 children of all ages with Down syndrome (DS). Only 48.1% (95%CI: 35.1-61.3) of the DS children aged 7-10 years and 31.9% (95%CI: 22.1-43.6) of the DS children aged >10 years had a protective anti-HBs titer (≥10 IU/L). The geometric mean anti-HBs titer was significantly lower in the DS children; this suggests booster vaccination for HBV may be needed.
Original languageEnglish
Pages (from-to)1682-1685
JournalJournal of Medical Virology
Volume89
Issue number9
DOIs
Publication statusPublished - 2017

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Down Syndrome
Hepatitis B

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Eijsvoogel, N. B., Hollegien, M. I., Bok, L. A., Derksen-Lubsen, A., Dikken, F., Leenders, A. C. A. P., ... de Vries, E. (2017). Declining antibody levels after hepatitis B vaccination in Down syndrome: A need for booster vaccination? Journal of Medical Virology, 89(9), 1682-1685. https://doi.org/10.1002/jmv.24813
Eijsvoogel, N.B. ; Hollegien, M.I. ; Bok, L.A. ; Derksen-Lubsen, A. ; Dikken, F. ; Leenders, A.C.A.P. ; Pijning, A. ; Post, E. ; Wojciechowski, M. ; Hilbink, M. ; de Vries, E. / Declining antibody levels after hepatitis B vaccination in Down syndrome : A need for booster vaccination?. In: Journal of Medical Virology. 2017 ; Vol. 89, No. 9. pp. 1682-1685.
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title = "Declining antibody levels after hepatitis B vaccination in Down syndrome: A need for booster vaccination?",
abstract = "We determined the anti-HBs titer in 227 children of all ages with Down syndrome (DS). Only 48.1{\%} (95{\%}CI: 35.1-61.3) of the DS children aged 7-10 years and 31.9{\%} (95{\%}CI: 22.1-43.6) of the DS children aged >10 years had a protective anti-HBs titer (≥10 IU/L). The geometric mean anti-HBs titer was significantly lower in the DS children; this suggests booster vaccination for HBV may be needed.",
author = "N.B. Eijsvoogel and M.I. Hollegien and L.A. Bok and A. Derksen-Lubsen and F. Dikken and A.C.A.P. Leenders and A. Pijning and E. Post and M. Wojciechowski and M. Hilbink and {de Vries}, E.",
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Eijsvoogel, NB, Hollegien, MI, Bok, LA, Derksen-Lubsen, A, Dikken, F, Leenders, ACAP, Pijning, A, Post, E, Wojciechowski, M, Hilbink, M & de Vries, E 2017, 'Declining antibody levels after hepatitis B vaccination in Down syndrome: A need for booster vaccination?', Journal of Medical Virology, vol. 89, no. 9, pp. 1682-1685. https://doi.org/10.1002/jmv.24813

Declining antibody levels after hepatitis B vaccination in Down syndrome : A need for booster vaccination? / Eijsvoogel, N.B.; Hollegien, M.I.; Bok, L.A.; Derksen-Lubsen, A.; Dikken, F.; Leenders, A.C.A.P.; Pijning, A.; Post, E.; Wojciechowski, M.; Hilbink, M.; de Vries, E.

In: Journal of Medical Virology, Vol. 89, No. 9, 2017, p. 1682-1685.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Declining antibody levels after hepatitis B vaccination in Down syndrome

T2 - A need for booster vaccination?

AU - Eijsvoogel, N.B.

AU - Hollegien, M.I.

AU - Bok, L.A.

AU - Derksen-Lubsen, A.

AU - Dikken, F.

AU - Leenders, A.C.A.P.

AU - Pijning, A.

AU - Post, E.

AU - Wojciechowski, M.

AU - Hilbink, M.

AU - de Vries, E.

PY - 2017

Y1 - 2017

N2 - We determined the anti-HBs titer in 227 children of all ages with Down syndrome (DS). Only 48.1% (95%CI: 35.1-61.3) of the DS children aged 7-10 years and 31.9% (95%CI: 22.1-43.6) of the DS children aged >10 years had a protective anti-HBs titer (≥10 IU/L). The geometric mean anti-HBs titer was significantly lower in the DS children; this suggests booster vaccination for HBV may be needed.

AB - We determined the anti-HBs titer in 227 children of all ages with Down syndrome (DS). Only 48.1% (95%CI: 35.1-61.3) of the DS children aged 7-10 years and 31.9% (95%CI: 22.1-43.6) of the DS children aged >10 years had a protective anti-HBs titer (≥10 IU/L). The geometric mean anti-HBs titer was significantly lower in the DS children; this suggests booster vaccination for HBV may be needed.

U2 - 10.1002/jmv.24813

DO - 10.1002/jmv.24813

M3 - Article

VL - 89

SP - 1682

EP - 1685

JO - Journal of Medical Virology

JF - Journal of Medical Virology

SN - 1096-9071

IS - 9

ER -

Eijsvoogel NB, Hollegien MI, Bok LA, Derksen-Lubsen A, Dikken F, Leenders ACAP et al. Declining antibody levels after hepatitis B vaccination in Down syndrome: A need for booster vaccination? Journal of Medical Virology. 2017;89(9):1682-1685. https://doi.org/10.1002/jmv.24813