Declining antibody levels after hepatitis B vaccination in Down syndrome: A need for booster vaccination?

N.B. Eijsvoogel, M.I. Hollegien, L.A. Bok, A. Derksen-Lubsen, F. Dikken, A.C.A.P. Leenders, A. Pijning, E. Post, M. Wojciechowski, M. Hilbink, E. de Vries

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Abstract

We determined the anti-HBs titer in 227 children of all ages with Down syndrome (DS). Only 48.1% (95%CI: 35.1-61.3) of the DS children aged 7-10 years and 31.9% (95%CI: 22.1-43.6) of the DS children aged >10 years had a protective anti-HBs titer (≥10 IU/L). The geometric mean anti-HBs titer was significantly lower in the DS children; this suggests booster vaccination for HBV may be needed.
Original languageEnglish
Pages (from-to)1682-1685
JournalJournal of Medical Virology
Volume89
Issue number9
DOIs
Publication statusPublished - 2017

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Eijsvoogel, N. B., Hollegien, M. I., Bok, L. A., Derksen-Lubsen, A., Dikken, F., Leenders, A. C. A. P., Pijning, A., Post, E., Wojciechowski, M., Hilbink, M., & de Vries, E. (2017). Declining antibody levels after hepatitis B vaccination in Down syndrome: A need for booster vaccination? Journal of Medical Virology, 89(9), 1682-1685. https://doi.org/10.1002/jmv.24813