Declining antibody levels after hepatitis B vaccination in Down syndrome: A need for booster vaccination?

N.B. Eijsvoogel; M.I. Hollegien; L.A. Bok; A. Derksen-Lubsen; F. Dikken; A.C.A.P. Leenders; A. Pijning; E. Post; M. Wojciechowski; M. Hilbink; E. de Vries

doi:10.1002/jmv.24813

Declining antibody levels after hepatitis B vaccination in Down syndrome: A need for booster vaccination?

N.B. Eijsvoogel, M.I. Hollegien, L.A. Bok, A. Derksen-Lubsen, F. Dikken, A.C.A.P. Leenders, A. Pijning, E. Post, M. Wojciechowski, M. Hilbink, E. de Vries

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Abstract

We determined the anti-HBs titer in 227 children of all ages with Down syndrome (DS). Only 48.1% (95%CI: 35.1-61.3) of the DS children aged 7-10 years and 31.9% (95%CI: 22.1-43.6) of the DS children aged >10 years had a protective anti-HBs titer (≥10 IU/L). The geometric mean anti-HBs titer was significantly lower in the DS children; this suggests booster vaccination for HBV may be needed.

Original language	English
Pages (from-to)	1682-1685
Journal	Journal of Medical Virology
Volume	89
Issue number	9
DOIs	https://doi.org/10.1002/jmv.24813
Publication status	Published - 2017

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10.1002/jmv.24813

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title = "Declining antibody levels after hepatitis B vaccination in Down syndrome: A need for booster vaccination?",

abstract = "We determined the anti-HBs titer in 227 children of all ages with Down syndrome (DS). Only 48.1% (95%CI: 35.1-61.3) of the DS children aged 7-10 years and 31.9% (95%CI: 22.1-43.6) of the DS children aged >10 years had a protective anti-HBs titer (≥10 IU/L). The geometric mean anti-HBs titer was significantly lower in the DS children; this suggests booster vaccination for HBV may be needed.",

author = "N.B. Eijsvoogel and M.I. Hollegien and L.A. Bok and A. Derksen-Lubsen and F. Dikken and A.C.A.P. Leenders and A. Pijning and E. Post and M. Wojciechowski and M. Hilbink and {de Vries}, E.",

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T1 - Declining antibody levels after hepatitis B vaccination in Down syndrome

T2 - A need for booster vaccination?

AU - Eijsvoogel, N.B.

AU - Hollegien, M.I.

AU - Bok, L.A.

AU - Derksen-Lubsen, A.

AU - Dikken, F.

AU - Leenders, A.C.A.P.

AU - Pijning, A.

AU - Post, E.

AU - Wojciechowski, M.

AU - Hilbink, M.

AU - de Vries, E.

PY - 2017

Y1 - 2017

N2 - We determined the anti-HBs titer in 227 children of all ages with Down syndrome (DS). Only 48.1% (95%CI: 35.1-61.3) of the DS children aged 7-10 years and 31.9% (95%CI: 22.1-43.6) of the DS children aged >10 years had a protective anti-HBs titer (≥10 IU/L). The geometric mean anti-HBs titer was significantly lower in the DS children; this suggests booster vaccination for HBV may be needed.

AB - We determined the anti-HBs titer in 227 children of all ages with Down syndrome (DS). Only 48.1% (95%CI: 35.1-61.3) of the DS children aged 7-10 years and 31.9% (95%CI: 22.1-43.6) of the DS children aged >10 years had a protective anti-HBs titer (≥10 IU/L). The geometric mean anti-HBs titer was significantly lower in the DS children; this suggests booster vaccination for HBV may be needed.

U2 - 10.1002/jmv.24813

DO - 10.1002/jmv.24813

M3 - Article

SN - 1096-9071

VL - 89

SP - 1682

EP - 1685

JO - Journal of Medical Virology

JF - Journal of Medical Virology

IS - 9

ER -

Declining antibody levels after hepatitis B vaccination in Down syndrome: A need for booster vaccination?

Abstract

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