Decreased antibody response after severe acute respiratory syndrome coronavirus 2 vaccination in patients with Down syndrom

Bianca M M Streng; Marin Bont; Eveline M Delemarre; Rob S Binnendijk; Gaby Smit; Gerco Den Hartog; Antonia M W Coppus; Esther De Vries; Michel E Weijerman; Regina Lamberts; Gert De Graaf; Fiona R Van Der Klis; Gestur Vidarsson; Neele Rave; Louis J Bont; Joanne G Wildenbeest

doi:10.1093/infdis/jiac235

Decreased antibody response after severe acute respiratory syndrome coronavirus 2 vaccination in patients with Down syndrom

Bianca M M Streng
, Marin Bont
, Eveline M Delemarre
, Rob S Binnendijk
, Gaby Smit
, Gerco Den Hartog
, Antonia M W Coppus
, Esther De Vries
, Michel E Weijerman
, Regina Lamberts
, Gert De Graaf
, Fiona R Van Der Klis
, Gestur Vidarsson
, Neele Rave
, Louis J Bont
, Joanne G Wildenbeest^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

3 Citations (Scopus)

67 Downloads (Pure)

Abstract

The risk of a severe course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in adults with Down syndrome is increased, resulting in an up to 10-fold increase in mortality, in particular in those >40 years of age. After primary SARS-CoV-2 vaccination, the higher risks remain. In this prospective observational cohort study, SARS-CoV-2 spike S1-specific antibody responses after routine SARS-CoV-2 vaccination (BNT162b2, messenger RNA [mRNA]-1273, or ChAdOx1) in adults with Down syndrome and healthy controls were compared. Adults with Down syndrome showed lower antibody concentrations after 2 mRNA vaccinations or after 2 ChAdOx1 vaccinations. After 2 mRNA vaccinations, lower antibody concentrations were seen with increasing age.

In this prospective cohort study that included 222 adults with Down syndrome, a significantly lower antibody response was found after SARS-CoV-2 mRNA or vector vaccination compared to healthy controls. After mRNA vaccination, lower antibodies were found with increasing age.

Original language	English
Pages (from-to)	673-677
Journal	The Journal of Infectious Diseases
Volume	226
Issue number	4
DOIs	https://doi.org/10.1093/infdis/jiac235
Publication status	Published - 2022

Keywords

Adult
Antibodies, Viral
Antibody Formation
BNT162 Vaccine
COVID-19 Vaccines
COVID-19/prevention & control
Down Syndrome
Humans
Prospective Studies
RNA, Messenger
SARS-CoV-2
Vaccination

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/infdis/jiac235Licence: CC BY-NC-ND

Tranzo de Vries SARS-CoV-2 down syndrome JoID 2022Final published version, 533 KBLicence: CC BY-NC-ND

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Streng, B. M. M., Bont, M., Delemarre, E. M., Binnendijk, R. S., Smit, G., Den Hartog, G., Coppus, A. M. W., De Vries, E., Weijerman, M. E., Lamberts, R., De Graaf, G., Van Der Klis, F. R., Vidarsson, G., Rave, N., Bont, L. J., & Wildenbeest, J. G. (2022). Decreased antibody response after severe acute respiratory syndrome coronavirus 2 vaccination in patients with Down syndrom. The Journal of Infectious Diseases, 226(4), 673-677. https://doi.org/10.1093/infdis/jiac235

@article{83a9f72b382543dba5c7ae0ecee3d2d9,

title = "Decreased antibody response after severe acute respiratory syndrome coronavirus 2 vaccination in patients with Down syndrom",

abstract = "The risk of a severe course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in adults with Down syndrome is increased, resulting in an up to 10-fold increase in mortality, in particular in those >40 years of age. After primary SARS-CoV-2 vaccination, the higher risks remain. In this prospective observational cohort study, SARS-CoV-2 spike S1-specific antibody responses after routine SARS-CoV-2 vaccination (BNT162b2, messenger RNA [mRNA]-1273, or ChAdOx1) in adults with Down syndrome and healthy controls were compared. Adults with Down syndrome showed lower antibody concentrations after 2 mRNA vaccinations or after 2 ChAdOx1 vaccinations. After 2 mRNA vaccinations, lower antibody concentrations were seen with increasing age.In this prospective cohort study that included 222 adults with Down syndrome, a significantly lower antibody response was found after SARS-CoV-2 mRNA or vector vaccination compared to healthy controls. After mRNA vaccination, lower antibodies were found with increasing age.",

keywords = "Adult, Antibodies, Viral, Antibody Formation, BNT162 Vaccine, COVID-19 Vaccines, COVID-19/prevention \& control, Down Syndrome, Humans, Prospective Studies, RNA, Messenger, SARS-CoV-2, Vaccination",

author = "Streng, \{Bianca M M\} and Marin Bont and Delemarre, \{Eveline M\} and Binnendijk, \{Rob S\} and Gaby Smit and \{Den Hartog\}, Gerco and Coppus, \{Antonia M W\} and \{De Vries\}, Esther and Weijerman, \{Michel E\} and Regina Lamberts and \{De Graaf\}, Gert and \{Van Der Klis\}, \{Fiona R\} and Gestur Vidarsson and Neele Rave and Bont, \{Louis J\} and Wildenbeest, \{Joanne G\}",

note = "This work was supported by ZonMw, The Netherlands Organization for Health Research and Development (10430072010004). Funding to pay the Open Access publication charges for this article was provided by the Dutch Universities and Academic Hospitals (VSNU).",

year = "2022",

doi = "10.1093/infdis/jiac235",

language = "English",

volume = "226",

pages = "673--677",

journal = "The Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "4",

}

Streng, BMM, Bont, M, Delemarre, EM, Binnendijk, RS, Smit, G, Den Hartog, G, Coppus, AMW, De Vries, E, Weijerman, ME, Lamberts, R, De Graaf, G, Van Der Klis, FR, Vidarsson, G, Rave, N, Bont, LJ & Wildenbeest, JG 2022, 'Decreased antibody response after severe acute respiratory syndrome coronavirus 2 vaccination in patients with Down syndrom', The Journal of Infectious Diseases, vol. 226, no. 4, pp. 673-677. https://doi.org/10.1093/infdis/jiac235

TY - JOUR

T1 - Decreased antibody response after severe acute respiratory syndrome coronavirus 2 vaccination in patients with Down syndrom

AU - Streng, Bianca M M

AU - Bont, Marin

AU - Delemarre, Eveline M

AU - Binnendijk, Rob S

AU - Smit, Gaby

AU - Den Hartog, Gerco

AU - Coppus, Antonia M W

AU - De Vries, Esther

AU - Weijerman, Michel E

AU - Lamberts, Regina

AU - De Graaf, Gert

AU - Van Der Klis, Fiona R

AU - Vidarsson, Gestur

AU - Rave, Neele

AU - Bont, Louis J

AU - Wildenbeest, Joanne G

N1 - This work was supported by ZonMw, The Netherlands Organization for Health Research and Development (10430072010004). Funding to pay the Open Access publication charges for this article was provided by the Dutch Universities and Academic Hospitals (VSNU).

PY - 2022

Y1 - 2022

N2 - The risk of a severe course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in adults with Down syndrome is increased, resulting in an up to 10-fold increase in mortality, in particular in those >40 years of age. After primary SARS-CoV-2 vaccination, the higher risks remain. In this prospective observational cohort study, SARS-CoV-2 spike S1-specific antibody responses after routine SARS-CoV-2 vaccination (BNT162b2, messenger RNA [mRNA]-1273, or ChAdOx1) in adults with Down syndrome and healthy controls were compared. Adults with Down syndrome showed lower antibody concentrations after 2 mRNA vaccinations or after 2 ChAdOx1 vaccinations. After 2 mRNA vaccinations, lower antibody concentrations were seen with increasing age.In this prospective cohort study that included 222 adults with Down syndrome, a significantly lower antibody response was found after SARS-CoV-2 mRNA or vector vaccination compared to healthy controls. After mRNA vaccination, lower antibodies were found with increasing age.

AB - The risk of a severe course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in adults with Down syndrome is increased, resulting in an up to 10-fold increase in mortality, in particular in those >40 years of age. After primary SARS-CoV-2 vaccination, the higher risks remain. In this prospective observational cohort study, SARS-CoV-2 spike S1-specific antibody responses after routine SARS-CoV-2 vaccination (BNT162b2, messenger RNA [mRNA]-1273, or ChAdOx1) in adults with Down syndrome and healthy controls were compared. Adults with Down syndrome showed lower antibody concentrations after 2 mRNA vaccinations or after 2 ChAdOx1 vaccinations. After 2 mRNA vaccinations, lower antibody concentrations were seen with increasing age.In this prospective cohort study that included 222 adults with Down syndrome, a significantly lower antibody response was found after SARS-CoV-2 mRNA or vector vaccination compared to healthy controls. After mRNA vaccination, lower antibodies were found with increasing age.

KW - Adult

KW - Antibodies, Viral

KW - Antibody Formation

KW - BNT162 Vaccine

KW - COVID-19 Vaccines

KW - COVID-19/prevention & control

KW - Down Syndrome

KW - Humans

KW - Prospective Studies

KW - RNA, Messenger

KW - SARS-CoV-2

KW - Vaccination

UR - https://clinicaltrials.gov/ct2/show/NCT05145348

UR - https://www.scopus.com/pages/publications/85137153699

U2 - 10.1093/infdis/jiac235

DO - 10.1093/infdis/jiac235

M3 - Article

C2 - 35748853

SN - 0022-1899

VL - 226

SP - 673

EP - 677

JO - The Journal of Infectious Diseases

JF - The Journal of Infectious Diseases

IS - 4

ER -

Decreased antibody response after severe acute respiratory syndrome coronavirus 2 vaccination in patients with Down syndrom

Abstract

Keywords

UN SDGs

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