Design of the SHAPE-2 study

The effect of physical activity, in addition to weight loss, on biomarkers of postmenopausal breast cancer risk

Willemijn A M van Gemert, Jolein I Iestra, A.J. Schuit, Anne M May, Tim Takken, Wouter B Veldhuis, Job van der Palen, Harriët Wittink, Petra H M Peeters, Evelyn M Monninkhof

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Background:

Physical inactivity and overweight are two known risk factors for postmenopausal breast cancer. Former exercise intervention studies showed that physical activity influences sex hormone levels, known to be related to postmenopausal breast cancer, mainly when concordant loss of body weight was achieved. The question remains whether there is an additional beneficial effect of physical activity when weight loss is reached.

Design:

The SHAPE-2 study is a three-armed, multicentre trial. 243 sedentary, postmenopausal women who are overweight or obese (BMI 25-35 kg/m2) are enrolled. After a 4-6 week run-in period, wherein a baseline diet is prescribed, women are randomly allocated to (1) a diet group, (2) an exercise group or (3) a control group. The aim of both intervention groups is to lose an amount of 5-6 kg body weight in 10-14 weeks. The diet group follows an energy restricted diet and maintains the habitual physical activity level. The exercise group participates in a 16-week endurance and strength training programme of 4 hours per week. Furthermore, they are prescribed a moderate caloric restriction. The control group is asked to maintain body weight and continue the run-in baseline diet.

Discussion:

This study will give insight in the potential attributable effect of physical activity on breast cancer risk biomarkers and whether this effect is mediated by changes in body composition, in postmenopausal women. Eventually this may lead to the design of specific lifestyle guidelines for prevention of breast cancer.


Original languageEnglish
Article number395
JournalBMC Cancer
Volume13
DOIs
Publication statusPublished - 23 Aug 2013
Externally publishedYes

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Exercise
Caloric Restriction
Resistance Training
Multicenter Studies
Education

Keywords

  • Aged
  • Biomarkers
  • Breast Neoplasms
  • Case-Control Studies
  • Diet, Reducing
  • Exercise
  • Female
  • Follow-Up Studies
  • Humans
  • Life Style
  • Middle Aged
  • Obesity
  • Overweight
  • Postmenopause
  • Prognosis
  • Risk Factors
  • Weight Loss
  • Comparative Study
  • Journal Article
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

Cite this

van Gemert, Willemijn A M ; Iestra, Jolein I ; Schuit, A.J. ; May, Anne M ; Takken, Tim ; Veldhuis, Wouter B ; van der Palen, Job ; Wittink, Harriët ; Peeters, Petra H M ; Monninkhof, Evelyn M. / Design of the SHAPE-2 study : The effect of physical activity, in addition to weight loss, on biomarkers of postmenopausal breast cancer risk. In: BMC Cancer. 2013 ; Vol. 13.
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abstract = "Background: Physical inactivity and overweight are two known risk factors for postmenopausal breast cancer. Former exercise intervention studies showed that physical activity influences sex hormone levels, known to be related to postmenopausal breast cancer, mainly when concordant loss of body weight was achieved. The question remains whether there is an additional beneficial effect of physical activity when weight loss is reached.Design: The SHAPE-2 study is a three-armed, multicentre trial. 243 sedentary, postmenopausal women who are overweight or obese (BMI 25-35 kg/m2) are enrolled. After a 4-6 week run-in period, wherein a baseline diet is prescribed, women are randomly allocated to (1) a diet group, (2) an exercise group or (3) a control group. The aim of both intervention groups is to lose an amount of 5-6 kg body weight in 10-14 weeks. The diet group follows an energy restricted diet and maintains the habitual physical activity level. The exercise group participates in a 16-week endurance and strength training programme of 4 hours per week. Furthermore, they are prescribed a moderate caloric restriction. The control group is asked to maintain body weight and continue the run-in baseline diet.Discussion: This study will give insight in the potential attributable effect of physical activity on breast cancer risk biomarkers and whether this effect is mediated by changes in body composition, in postmenopausal women. Eventually this may lead to the design of specific lifestyle guidelines for prevention of breast cancer.",
keywords = "Aged, Biomarkers, Breast Neoplasms, Case-Control Studies, Diet, Reducing, Exercise, Female, Follow-Up Studies, Humans, Life Style, Middle Aged, Obesity, Overweight, Postmenopause, Prognosis, Risk Factors, Weight Loss, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't",
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year = "2013",
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van Gemert, WAM, Iestra, JI, Schuit, AJ, May, AM, Takken, T, Veldhuis, WB, van der Palen, J, Wittink, H, Peeters, PHM & Monninkhof, EM 2013, 'Design of the SHAPE-2 study: The effect of physical activity, in addition to weight loss, on biomarkers of postmenopausal breast cancer risk', BMC Cancer, vol. 13, 395. https://doi.org/10.1186/1471-2407-13-395

Design of the SHAPE-2 study : The effect of physical activity, in addition to weight loss, on biomarkers of postmenopausal breast cancer risk. / van Gemert, Willemijn A M; Iestra, Jolein I; Schuit, A.J.; May, Anne M; Takken, Tim; Veldhuis, Wouter B; van der Palen, Job; Wittink, Harriët; Peeters, Petra H M; Monninkhof, Evelyn M.

In: BMC Cancer, Vol. 13, 395, 23.08.2013.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Design of the SHAPE-2 study

T2 - The effect of physical activity, in addition to weight loss, on biomarkers of postmenopausal breast cancer risk

AU - van Gemert, Willemijn A M

AU - Iestra, Jolein I

AU - Schuit, A.J.

AU - May, Anne M

AU - Takken, Tim

AU - Veldhuis, Wouter B

AU - van der Palen, Job

AU - Wittink, Harriët

AU - Peeters, Petra H M

AU - Monninkhof, Evelyn M

PY - 2013/8/23

Y1 - 2013/8/23

N2 - Background: Physical inactivity and overweight are two known risk factors for postmenopausal breast cancer. Former exercise intervention studies showed that physical activity influences sex hormone levels, known to be related to postmenopausal breast cancer, mainly when concordant loss of body weight was achieved. The question remains whether there is an additional beneficial effect of physical activity when weight loss is reached.Design: The SHAPE-2 study is a three-armed, multicentre trial. 243 sedentary, postmenopausal women who are overweight or obese (BMI 25-35 kg/m2) are enrolled. After a 4-6 week run-in period, wherein a baseline diet is prescribed, women are randomly allocated to (1) a diet group, (2) an exercise group or (3) a control group. The aim of both intervention groups is to lose an amount of 5-6 kg body weight in 10-14 weeks. The diet group follows an energy restricted diet and maintains the habitual physical activity level. The exercise group participates in a 16-week endurance and strength training programme of 4 hours per week. Furthermore, they are prescribed a moderate caloric restriction. The control group is asked to maintain body weight and continue the run-in baseline diet.Discussion: This study will give insight in the potential attributable effect of physical activity on breast cancer risk biomarkers and whether this effect is mediated by changes in body composition, in postmenopausal women. Eventually this may lead to the design of specific lifestyle guidelines for prevention of breast cancer.

AB - Background: Physical inactivity and overweight are two known risk factors for postmenopausal breast cancer. Former exercise intervention studies showed that physical activity influences sex hormone levels, known to be related to postmenopausal breast cancer, mainly when concordant loss of body weight was achieved. The question remains whether there is an additional beneficial effect of physical activity when weight loss is reached.Design: The SHAPE-2 study is a three-armed, multicentre trial. 243 sedentary, postmenopausal women who are overweight or obese (BMI 25-35 kg/m2) are enrolled. After a 4-6 week run-in period, wherein a baseline diet is prescribed, women are randomly allocated to (1) a diet group, (2) an exercise group or (3) a control group. The aim of both intervention groups is to lose an amount of 5-6 kg body weight in 10-14 weeks. The diet group follows an energy restricted diet and maintains the habitual physical activity level. The exercise group participates in a 16-week endurance and strength training programme of 4 hours per week. Furthermore, they are prescribed a moderate caloric restriction. The control group is asked to maintain body weight and continue the run-in baseline diet.Discussion: This study will give insight in the potential attributable effect of physical activity on breast cancer risk biomarkers and whether this effect is mediated by changes in body composition, in postmenopausal women. Eventually this may lead to the design of specific lifestyle guidelines for prevention of breast cancer.

KW - Aged

KW - Biomarkers

KW - Breast Neoplasms

KW - Case-Control Studies

KW - Diet, Reducing

KW - Exercise

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Life Style

KW - Middle Aged

KW - Obesity

KW - Overweight

KW - Postmenopause

KW - Prognosis

KW - Risk Factors

KW - Weight Loss

KW - Comparative Study

KW - Journal Article

KW - Multicenter Study

KW - Randomized Controlled Trial

KW - Research Support, Non-U.S. Gov't

U2 - 10.1186/1471-2407-13-395

DO - 10.1186/1471-2407-13-395

M3 - Article

VL - 13

JO - BMC Cancer

JF - BMC Cancer

SN - 1471-2407

M1 - 395

ER -