Development and body mass inversely affect children's brain activation in dorsolateral prefrontal cortex during food choice

I.Family Consortium

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Childhood obesity is a rising problem caused in part by unhealthy food choices. Food choices are based on a neural value signal encoded in the ventromedial prefrontal cortex, and self-control involves modulation of this signal by the dorsolateral prefrontal cortex (dlPFC). We determined the effects of development, body mass (BMI Cole score) and body mass history on the neural correlates of healthy food choice in children. 141 children (aged 10-17y) from Germany, Hungary and Sweden were scanned with fMRI while performing a food choice task. Afterwards health and taste ratings of the foods were collected. In the food choice task children were asked to consider the healthiness or tastiness of the food or to choose naturally. Overall, children made healthier choices when asked to consider healthiness. However, children who had a higher weight gain per year chose less healthy foods when considering healthiness but not when choosing naturally. Pubertal development stage correlated positively while current body mass correlated negatively with dlPFC activation when accepting foods. Pubertal development negatively and current body mass positively influenced the effect of considering healthiness on activation of brain areas involved in salience and motivation. In conclusion, children in earlier stages of pubertal development and children with a higher body weight exhibited less activation in the dlPFC, which has been implicated in self-control during food choice. Furthermore, pubertal development and body mass influenced neural responses to a health cue in areas involved in salience and motivation. Thus, these findings suggest that children in earlier stages of pubertal development, children with a higher body mass gain and children with overweight may possibly be less susceptible to healthy eating interventions that rely on self-control or that highlight health aspects of food.

Original languageEnglish
Article number116016
Pages (from-to)116016
Number of pages10
JournalNeuroimage
Volume201
DOIs
Publication statusPublished - 1 Nov 2019

Fingerprint

Hungary
Pediatric Obesity
Weight Gain
Cues
Germany
History
Self-Control
Healthy Diet

Keywords

  • COMMERCIALS
  • DECISION-MAKING
  • Decision making
  • Development
  • FMRI
  • Food choice
  • OBESE CHILDREN
  • OVERWEIGHT
  • Overweight
  • REWARD
  • SIGNALS
  • STRIATAL RESPONSE
  • VALUATION
  • WEIGHT-GAIN
  • fMRI

Cite this

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title = "Development and body mass inversely affect children's brain activation in dorsolateral prefrontal cortex during food choice",
abstract = "Childhood obesity is a rising problem caused in part by unhealthy food choices. Food choices are based on a neural value signal encoded in the ventromedial prefrontal cortex, and self-control involves modulation of this signal by the dorsolateral prefrontal cortex (dlPFC). We determined the effects of development, body mass (BMI Cole score) and body mass history on the neural correlates of healthy food choice in children. 141 children (aged 10-17y) from Germany, Hungary and Sweden were scanned with fMRI while performing a food choice task. Afterwards health and taste ratings of the foods were collected. In the food choice task children were asked to consider the healthiness or tastiness of the food or to choose naturally. Overall, children made healthier choices when asked to consider healthiness. However, children who had a higher weight gain per year chose less healthy foods when considering healthiness but not when choosing naturally. Pubertal development stage correlated positively while current body mass correlated negatively with dlPFC activation when accepting foods. Pubertal development negatively and current body mass positively influenced the effect of considering healthiness on activation of brain areas involved in salience and motivation. In conclusion, children in earlier stages of pubertal development and children with a higher body weight exhibited less activation in the dlPFC, which has been implicated in self-control during food choice. Furthermore, pubertal development and body mass influenced neural responses to a health cue in areas involved in salience and motivation. Thus, these findings suggest that children in earlier stages of pubertal development, children with a higher body mass gain and children with overweight may possibly be less susceptible to healthy eating interventions that rely on self-control or that highlight health aspects of food.",
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author = "{I.Family Consortium} and {van Meer}, Floor and {van der Laan}, {Laura N} and Gabriele Eiben and Lauren Lissner and Maike Wolters and Stefan Rach and Manfred Herrmann and Peter Erhard and Denes Molnar and Gergely Orsi and Viergever, {Max A} and Adan, {Roger A H} and Smeets, {Paul A M}",
note = "Copyright {\circledC} 2019 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2019",
month = "11",
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language = "English",
volume = "201",
pages = "116016",
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Development and body mass inversely affect children's brain activation in dorsolateral prefrontal cortex during food choice. / I.Family Consortium.

In: Neuroimage, Vol. 201, 116016, 01.11.2019, p. 116016.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Development and body mass inversely affect children's brain activation in dorsolateral prefrontal cortex during food choice

AU - I.Family Consortium

AU - van Meer, Floor

AU - van der Laan, Laura N

AU - Eiben, Gabriele

AU - Lissner, Lauren

AU - Wolters, Maike

AU - Rach, Stefan

AU - Herrmann, Manfred

AU - Erhard, Peter

AU - Molnar, Denes

AU - Orsi, Gergely

AU - Viergever, Max A

AU - Adan, Roger A H

AU - Smeets, Paul A M

N1 - Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Childhood obesity is a rising problem caused in part by unhealthy food choices. Food choices are based on a neural value signal encoded in the ventromedial prefrontal cortex, and self-control involves modulation of this signal by the dorsolateral prefrontal cortex (dlPFC). We determined the effects of development, body mass (BMI Cole score) and body mass history on the neural correlates of healthy food choice in children. 141 children (aged 10-17y) from Germany, Hungary and Sweden were scanned with fMRI while performing a food choice task. Afterwards health and taste ratings of the foods were collected. In the food choice task children were asked to consider the healthiness or tastiness of the food or to choose naturally. Overall, children made healthier choices when asked to consider healthiness. However, children who had a higher weight gain per year chose less healthy foods when considering healthiness but not when choosing naturally. Pubertal development stage correlated positively while current body mass correlated negatively with dlPFC activation when accepting foods. Pubertal development negatively and current body mass positively influenced the effect of considering healthiness on activation of brain areas involved in salience and motivation. In conclusion, children in earlier stages of pubertal development and children with a higher body weight exhibited less activation in the dlPFC, which has been implicated in self-control during food choice. Furthermore, pubertal development and body mass influenced neural responses to a health cue in areas involved in salience and motivation. Thus, these findings suggest that children in earlier stages of pubertal development, children with a higher body mass gain and children with overweight may possibly be less susceptible to healthy eating interventions that rely on self-control or that highlight health aspects of food.

AB - Childhood obesity is a rising problem caused in part by unhealthy food choices. Food choices are based on a neural value signal encoded in the ventromedial prefrontal cortex, and self-control involves modulation of this signal by the dorsolateral prefrontal cortex (dlPFC). We determined the effects of development, body mass (BMI Cole score) and body mass history on the neural correlates of healthy food choice in children. 141 children (aged 10-17y) from Germany, Hungary and Sweden were scanned with fMRI while performing a food choice task. Afterwards health and taste ratings of the foods were collected. In the food choice task children were asked to consider the healthiness or tastiness of the food or to choose naturally. Overall, children made healthier choices when asked to consider healthiness. However, children who had a higher weight gain per year chose less healthy foods when considering healthiness but not when choosing naturally. Pubertal development stage correlated positively while current body mass correlated negatively with dlPFC activation when accepting foods. Pubertal development negatively and current body mass positively influenced the effect of considering healthiness on activation of brain areas involved in salience and motivation. In conclusion, children in earlier stages of pubertal development and children with a higher body weight exhibited less activation in the dlPFC, which has been implicated in self-control during food choice. Furthermore, pubertal development and body mass influenced neural responses to a health cue in areas involved in salience and motivation. Thus, these findings suggest that children in earlier stages of pubertal development, children with a higher body mass gain and children with overweight may possibly be less susceptible to healthy eating interventions that rely on self-control or that highlight health aspects of food.

KW - COMMERCIALS

KW - DECISION-MAKING

KW - Decision making

KW - Development

KW - FMRI

KW - Food choice

KW - OBESE CHILDREN

KW - OVERWEIGHT

KW - Overweight

KW - REWARD

KW - SIGNALS

KW - STRIATAL RESPONSE

KW - VALUATION

KW - WEIGHT-GAIN

KW - fMRI

U2 - 10.1016/j.neuroimage.2019.116016

DO - 10.1016/j.neuroimage.2019.116016

M3 - Article

VL - 201

SP - 116016

JO - Neuroimage

JF - Neuroimage

SN - 1053-8119

M1 - 116016

ER -