Developmental differences in the brain response to unhealthy food cues

an fMRI study of children and adults

I.Family Consortium

Research output: Contribution to journalArticleScientificpeer-review

Abstract

BACKGROUND: Food cues are omnipresent and may trigger overconsumption. In the past 2 decades, the prevalence of childhood obesity has increased dramatically. Because children's brains are still developing, especially in areas important for inhibition, children may be more susceptible than adults to tempting food cues.

OBJECTIVE: We examined potential developmental differences in children's and adults' responses to food cues to determine how these responses relate to weight status.

DESIGN: We included 27 children aged 10-12 y and 32 adults aged 32-52 y. Functional magnetic resonance imaging data were acquired during a food-viewing task in which unhealthy and healthy food pictures were presented.

RESULTS: Children had a stronger activation in the left precentral gyrus than did adults in response to unhealthy compared with healthy foods. In children, unhealthy foods elicited stronger activation in the right inferior temporal and middle occipital gyri, left precentral gyrus, bilateral opercular part of the inferior frontal gyrus, left hippocampus, and left middle frontal gyrus. Adults had stronger activation in the bilateral middle occipital gyrus and the right calcarine sulcus for unhealthy compared with healthy foods. Children with a higher body mass index (BMI) had lower activation in the bilateral dorsolateral prefrontal cortex while viewing unhealthy compared with healthy foods. In adults there was no correlation between BMI and neural response to unhealthy compared with healthy foods.

CONCLUSIONS: Unhealthy foods might elicit more attention both in children and in adults. Children had stronger activation while viewing unhealthy compared with healthy foods in areas involved in reward, motivation, and memory. Furthermore, children activated a motivation and reward area located in the motor cortex more strongly than did adults in response to unhealthy foods. Finally, children with a higher BMI had less activation in inhibitory areas in response to unhealthy foods, which may mean they are more susceptible to tempting food cues. This trial was registered at www.trialregister.nl as NTR4255.

Original languageEnglish
Pages (from-to)1515-1522
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume104
Issue number6
DOIs
Publication statusPublished - Dec 2016
Externally publishedYes

Fingerprint

Cues
Body Mass Index
Pediatric Obesity
Motor Cortex

Keywords

  • Adult
  • Age Factors
  • Attention
  • Body Mass Index
  • Body Weight
  • Brain Mapping
  • Cerebral Cortex/diagnostic imaging
  • Child
  • Cues
  • Female
  • Food
  • Healthy Diet
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Motivation
  • Prefrontal Cortex/diagnostic imaging
  • Reward

Cite this

@article{1310673f7bd74d4f9d5eb896de1d248a,
title = "Developmental differences in the brain response to unhealthy food cues: an fMRI study of children and adults",
abstract = "BACKGROUND: Food cues are omnipresent and may trigger overconsumption. In the past 2 decades, the prevalence of childhood obesity has increased dramatically. Because children's brains are still developing, especially in areas important for inhibition, children may be more susceptible than adults to tempting food cues.OBJECTIVE: We examined potential developmental differences in children's and adults' responses to food cues to determine how these responses relate to weight status.DESIGN: We included 27 children aged 10-12 y and 32 adults aged 32-52 y. Functional magnetic resonance imaging data were acquired during a food-viewing task in which unhealthy and healthy food pictures were presented.RESULTS: Children had a stronger activation in the left precentral gyrus than did adults in response to unhealthy compared with healthy foods. In children, unhealthy foods elicited stronger activation in the right inferior temporal and middle occipital gyri, left precentral gyrus, bilateral opercular part of the inferior frontal gyrus, left hippocampus, and left middle frontal gyrus. Adults had stronger activation in the bilateral middle occipital gyrus and the right calcarine sulcus for unhealthy compared with healthy foods. Children with a higher body mass index (BMI) had lower activation in the bilateral dorsolateral prefrontal cortex while viewing unhealthy compared with healthy foods. In adults there was no correlation between BMI and neural response to unhealthy compared with healthy foods.CONCLUSIONS: Unhealthy foods might elicit more attention both in children and in adults. Children had stronger activation while viewing unhealthy compared with healthy foods in areas involved in reward, motivation, and memory. Furthermore, children activated a motivation and reward area located in the motor cortex more strongly than did adults in response to unhealthy foods. Finally, children with a higher BMI had less activation in inhibitory areas in response to unhealthy foods, which may mean they are more susceptible to tempting food cues. This trial was registered at www.trialregister.nl as NTR4255.",
keywords = "Adult, Age Factors, Attention, Body Mass Index, Body Weight, Brain Mapping, Cerebral Cortex/diagnostic imaging, Child, Cues, Female, Food, Healthy Diet, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Motivation, Prefrontal Cortex/diagnostic imaging, Reward",
author = "{I.Family Consortium} and {van Meer}, Floor and {van der Laan}, {Laura N} and Lisette Charbonnier and Viergever, {Max A} and Adan, {Roger Ah} and Smeets, {Paul Am}",
note = "{\circledC} 2016 American Society for Nutrition.",
year = "2016",
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doi = "10.3945/ajcn.116.137240",
language = "English",
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Developmental differences in the brain response to unhealthy food cues : an fMRI study of children and adults. / I.Family Consortium.

In: American Journal of Clinical Nutrition, Vol. 104, No. 6, 12.2016, p. 1515-1522.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Developmental differences in the brain response to unhealthy food cues

T2 - an fMRI study of children and adults

AU - I.Family Consortium

AU - van Meer, Floor

AU - van der Laan, Laura N

AU - Charbonnier, Lisette

AU - Viergever, Max A

AU - Adan, Roger Ah

AU - Smeets, Paul Am

N1 - © 2016 American Society for Nutrition.

PY - 2016/12

Y1 - 2016/12

N2 - BACKGROUND: Food cues are omnipresent and may trigger overconsumption. In the past 2 decades, the prevalence of childhood obesity has increased dramatically. Because children's brains are still developing, especially in areas important for inhibition, children may be more susceptible than adults to tempting food cues.OBJECTIVE: We examined potential developmental differences in children's and adults' responses to food cues to determine how these responses relate to weight status.DESIGN: We included 27 children aged 10-12 y and 32 adults aged 32-52 y. Functional magnetic resonance imaging data were acquired during a food-viewing task in which unhealthy and healthy food pictures were presented.RESULTS: Children had a stronger activation in the left precentral gyrus than did adults in response to unhealthy compared with healthy foods. In children, unhealthy foods elicited stronger activation in the right inferior temporal and middle occipital gyri, left precentral gyrus, bilateral opercular part of the inferior frontal gyrus, left hippocampus, and left middle frontal gyrus. Adults had stronger activation in the bilateral middle occipital gyrus and the right calcarine sulcus for unhealthy compared with healthy foods. Children with a higher body mass index (BMI) had lower activation in the bilateral dorsolateral prefrontal cortex while viewing unhealthy compared with healthy foods. In adults there was no correlation between BMI and neural response to unhealthy compared with healthy foods.CONCLUSIONS: Unhealthy foods might elicit more attention both in children and in adults. Children had stronger activation while viewing unhealthy compared with healthy foods in areas involved in reward, motivation, and memory. Furthermore, children activated a motivation and reward area located in the motor cortex more strongly than did adults in response to unhealthy foods. Finally, children with a higher BMI had less activation in inhibitory areas in response to unhealthy foods, which may mean they are more susceptible to tempting food cues. This trial was registered at www.trialregister.nl as NTR4255.

AB - BACKGROUND: Food cues are omnipresent and may trigger overconsumption. In the past 2 decades, the prevalence of childhood obesity has increased dramatically. Because children's brains are still developing, especially in areas important for inhibition, children may be more susceptible than adults to tempting food cues.OBJECTIVE: We examined potential developmental differences in children's and adults' responses to food cues to determine how these responses relate to weight status.DESIGN: We included 27 children aged 10-12 y and 32 adults aged 32-52 y. Functional magnetic resonance imaging data were acquired during a food-viewing task in which unhealthy and healthy food pictures were presented.RESULTS: Children had a stronger activation in the left precentral gyrus than did adults in response to unhealthy compared with healthy foods. In children, unhealthy foods elicited stronger activation in the right inferior temporal and middle occipital gyri, left precentral gyrus, bilateral opercular part of the inferior frontal gyrus, left hippocampus, and left middle frontal gyrus. Adults had stronger activation in the bilateral middle occipital gyrus and the right calcarine sulcus for unhealthy compared with healthy foods. Children with a higher body mass index (BMI) had lower activation in the bilateral dorsolateral prefrontal cortex while viewing unhealthy compared with healthy foods. In adults there was no correlation between BMI and neural response to unhealthy compared with healthy foods.CONCLUSIONS: Unhealthy foods might elicit more attention both in children and in adults. Children had stronger activation while viewing unhealthy compared with healthy foods in areas involved in reward, motivation, and memory. Furthermore, children activated a motivation and reward area located in the motor cortex more strongly than did adults in response to unhealthy foods. Finally, children with a higher BMI had less activation in inhibitory areas in response to unhealthy foods, which may mean they are more susceptible to tempting food cues. This trial was registered at www.trialregister.nl as NTR4255.

KW - Adult

KW - Age Factors

KW - Attention

KW - Body Mass Index

KW - Body Weight

KW - Brain Mapping

KW - Cerebral Cortex/diagnostic imaging

KW - Child

KW - Cues

KW - Female

KW - Food

KW - Healthy Diet

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Motivation

KW - Prefrontal Cortex/diagnostic imaging

KW - Reward

U2 - 10.3945/ajcn.116.137240

DO - 10.3945/ajcn.116.137240

M3 - Article

VL - 104

SP - 1515

EP - 1522

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 6

ER -