Disease-specific health status as a predictor of mortality in patients with heart failure

A systematic literature review and meta-analysis of prospective cohort studies

M.H. Mastenbroek, H. Versteeg, W.P. Zijlstra, M.M. Meine, J.A. Spertus, S.S. Pedersen

Research output: Contribution to journalReview articleScientificpeer-review

Abstract

Aims
Some, but not all, studies have shown that patient-reported health status, including symptoms, functioning, and health-related quality of life, provides additional information to traditional clinical factors in predicting prognosis in heart failure patients. To evaluate the overall evidence, the association of disease-specific health status on mortality in heart failure was examined through a systematic review and meta-analysis.
Methods and results
Prospective cohort studies that assessed the independent association of disease-specific health status with mortality in heart failure were selected. Searching PubMed (until March 2013) resulted in 17 articles in the systematic review and 17 studies in the meta-analysis. About half of the studies reported a significant relationship between disease-specific health status and mortality in heart failure, while the remainder found no association. A larger sample size increased the chance of identification of a significant association. The results of the meta-analysis (including studies using a dichotomized heart failure-specific health status variable as predictor) showed that heart failure patients reporting poor disease-specific health status had a 39% increased risk of dying [hazard ratio 1.39 (1.25–1.54)] when compared with patients experiencing moderate or good disease-specific health status.
Conclusion
Patient-reported health status was an independent risk indicator for mortality in heart failure patients and may facilitate the identification of patients at high risk for poor prognosis above and beyond traditional risk variables. These findings suggest that patient-reported health status should be routinely assessed in determining prognosis, as this information cannot be captured from patients' medical records.
Original languageEnglish
Pages (from-to)384–393
JournalEuropean Journal of Heart Failure
Volume16
Issue number4
DOIs
Publication statusPublished - 2014

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Mastenbroek, M.H. ; Versteeg, H. ; Zijlstra, W.P. ; Meine, M.M. ; Spertus, J.A. ; Pedersen, S.S. / Disease-specific health status as a predictor of mortality in patients with heart failure : A systematic literature review and meta-analysis of prospective cohort studies. In: European Journal of Heart Failure. 2014 ; Vol. 16, No. 4. pp. 384–393.
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title = "Disease-specific health status as a predictor of mortality in patients with heart failure: A systematic literature review and meta-analysis of prospective cohort studies",
abstract = "AimsSome, but not all, studies have shown that patient-reported health status, including symptoms, functioning, and health-related quality of life, provides additional information to traditional clinical factors in predicting prognosis in heart failure patients. To evaluate the overall evidence, the association of disease-specific health status on mortality in heart failure was examined through a systematic review and meta-analysis.Methods and resultsProspective cohort studies that assessed the independent association of disease-specific health status with mortality in heart failure were selected. Searching PubMed (until March 2013) resulted in 17 articles in the systematic review and 17 studies in the meta-analysis. About half of the studies reported a significant relationship between disease-specific health status and mortality in heart failure, while the remainder found no association. A larger sample size increased the chance of identification of a significant association. The results of the meta-analysis (including studies using a dichotomized heart failure-specific health status variable as predictor) showed that heart failure patients reporting poor disease-specific health status had a 39{\%} increased risk of dying [hazard ratio 1.39 (1.25–1.54)] when compared with patients experiencing moderate or good disease-specific health status.ConclusionPatient-reported health status was an independent risk indicator for mortality in heart failure patients and may facilitate the identification of patients at high risk for poor prognosis above and beyond traditional risk variables. These findings suggest that patient-reported health status should be routinely assessed in determining prognosis, as this information cannot be captured from patients' medical records.",
author = "M.H. Mastenbroek and H. Versteeg and W.P. Zijlstra and M.M. Meine and J.A. Spertus and S.S. Pedersen",
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Disease-specific health status as a predictor of mortality in patients with heart failure : A systematic literature review and meta-analysis of prospective cohort studies. / Mastenbroek, M.H.; Versteeg, H.; Zijlstra, W.P.; Meine, M.M.; Spertus, J.A.; Pedersen, S.S.

In: European Journal of Heart Failure, Vol. 16, No. 4, 2014, p. 384–393.

Research output: Contribution to journalReview articleScientificpeer-review

TY - JOUR

T1 - Disease-specific health status as a predictor of mortality in patients with heart failure

T2 - A systematic literature review and meta-analysis of prospective cohort studies

AU - Mastenbroek, M.H.

AU - Versteeg, H.

AU - Zijlstra, W.P.

AU - Meine, M.M.

AU - Spertus, J.A.

AU - Pedersen, S.S.

PY - 2014

Y1 - 2014

N2 - AimsSome, but not all, studies have shown that patient-reported health status, including symptoms, functioning, and health-related quality of life, provides additional information to traditional clinical factors in predicting prognosis in heart failure patients. To evaluate the overall evidence, the association of disease-specific health status on mortality in heart failure was examined through a systematic review and meta-analysis.Methods and resultsProspective cohort studies that assessed the independent association of disease-specific health status with mortality in heart failure were selected. Searching PubMed (until March 2013) resulted in 17 articles in the systematic review and 17 studies in the meta-analysis. About half of the studies reported a significant relationship between disease-specific health status and mortality in heart failure, while the remainder found no association. A larger sample size increased the chance of identification of a significant association. The results of the meta-analysis (including studies using a dichotomized heart failure-specific health status variable as predictor) showed that heart failure patients reporting poor disease-specific health status had a 39% increased risk of dying [hazard ratio 1.39 (1.25–1.54)] when compared with patients experiencing moderate or good disease-specific health status.ConclusionPatient-reported health status was an independent risk indicator for mortality in heart failure patients and may facilitate the identification of patients at high risk for poor prognosis above and beyond traditional risk variables. These findings suggest that patient-reported health status should be routinely assessed in determining prognosis, as this information cannot be captured from patients' medical records.

AB - AimsSome, but not all, studies have shown that patient-reported health status, including symptoms, functioning, and health-related quality of life, provides additional information to traditional clinical factors in predicting prognosis in heart failure patients. To evaluate the overall evidence, the association of disease-specific health status on mortality in heart failure was examined through a systematic review and meta-analysis.Methods and resultsProspective cohort studies that assessed the independent association of disease-specific health status with mortality in heart failure were selected. Searching PubMed (until March 2013) resulted in 17 articles in the systematic review and 17 studies in the meta-analysis. About half of the studies reported a significant relationship between disease-specific health status and mortality in heart failure, while the remainder found no association. A larger sample size increased the chance of identification of a significant association. The results of the meta-analysis (including studies using a dichotomized heart failure-specific health status variable as predictor) showed that heart failure patients reporting poor disease-specific health status had a 39% increased risk of dying [hazard ratio 1.39 (1.25–1.54)] when compared with patients experiencing moderate or good disease-specific health status.ConclusionPatient-reported health status was an independent risk indicator for mortality in heart failure patients and may facilitate the identification of patients at high risk for poor prognosis above and beyond traditional risk variables. These findings suggest that patient-reported health status should be routinely assessed in determining prognosis, as this information cannot be captured from patients' medical records.

U2 - 10.1002/ejhf.55

DO - 10.1002/ejhf.55

M3 - Review article

VL - 16

SP - 384

EP - 393

JO - European Journal of Heart Failure

JF - European Journal of Heart Failure

SN - 1388-9842

IS - 4

ER -