Does extended surgery influence health-related quality of life in patients with rectal cancer?

R. Orsini, T.A. Vermeer, M.J. Traa, G.A.P. Nieuwenhuijzen, I.H.J.T. de Hingh, H.J. Rutten

Research output: Contribution to journalArticleScientificpeer-review

6 Citations (Scopus)

Abstract

Background: 
In locally advanced rectal cancer, an extended resection peripheral to the mesorectal fascia is needed to achieve a radical resection. The influence of extended resections on health-related quality of life is unclear.
Objective: Differences in health-related quality of life and sexuality between patients receiving standard surgery and patients receiving extended surgery were examined, with a focus on age.
Design: 
Patients operated on for rectal cancer between 2000 and 2010 were selected from a database and invited to complete the European Organization for Research and Treatment of Cancer quality-of-life questionnaires (C30 and ColoRectal 38).
Settings: 
All patients were treated at the Catharina Hospital, Eindhoven, the Netherlands.
Patients: 
All patients received total mesorectal excision surgery or extended surgery for rectal cancer.
Main outcome measures: Health-related quality of life and sexual activity was compared between patients treated with total mesorectal excision surgery and extended surgery and further stratified by age at the time of surgery (<70 and ≥70).RESULTS: Two hundred twenty-nine (64.1%) patients with standard surgery and 128 (35.9%) patients treated with extended resections responded. Extended surgery in patients <70 years resulted in lower body image compared with patients <70 years receiving standard surgery. Patients ≥70 years had lower sexual function and more male sexual dysfunction than patients <70 years undergoing standard surgery. In all groups, sexual activity dropped significantly after treatment.LIMITATIONS: No information was available of the patients' health-related quality of life before treatment except for the retrospective question about sexual activity.
Conclusions: 
This study showed no major differences between patients undergoing total mesorectal excision surgery and those receiving extended surgery, with the exception of body image, which was significantly lower in patients <70 years undergoing extended surgery. In all patient groups, treatment for rectal cancer influenced sexual activity dramatically. Awareness of the impact of surgery on health-related quality of life and sexuality is needed.
Original languageEnglish
Pages (from-to)179-185
JournalDiseases of the Colon & Rectum
Volume58
Issue number2
DOIs
Publication statusPublished - 2015

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