Does physical training reduce fatigue in sarcoidosis?

R. G. J. Marcellis, M.A.F. van der Veeke, I. Mesters, M. Drent, R.A. Bie, Jolanda de Vries, A.F. Lenssen

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Background:
Sarcoidosis patients frequently experience fatigue, exercise intolerance and muscle weakness, resulting in reduced quality of life (QOL). Scientific studies on the benefits of physical training in sarcoidosis have been scarce, so the aim of this pilot study was to examine the impact of a 13-week physical training program on fatigue, physical functions and QOL in fatigued sarcoidosis patients and/or patients with exercise intolerance.
Methods:
18 sarcoidosis patients participated in a 13-week physical training program. The
Fatigue Assessment Scale (FAS), World Health Organization Quality of Life-BREF assessment instrument (WHOQOL-BREF),Medical Research Council (MRC) dyspnea scale, Visual Analogue Scale (VAS), six-minute walk test (6MWT), submaximal bicycle test and muscle strength of the quadriceps and elbow flexors were assessed at baseline and after the program.
Results:
FAS scores had decreased (mean difference -2.7 points, 95% CI -4.4 to -1.1) after completion of the training program, along with improvements in WHOQOL-
BREF psychological health domain (mean difference 0.9 points, 95% CI 0.2 to 1.7) and MRC dyspnea score (mean difference -0.4 points, 95% CI -0.8 to -0.1). 6MWD improved by 34.6 m (95% CI 20.3 to 49.0) and mean heart rate on the bicycle test improved (mean difference 8.4 beats/minute, 95% CI -13.8 to -3.0), as did quadriceps strength (mean difference 10.7 kg, 95% CI 5.5 to 15.9).
Conclusion:
Fatigue reduced after a period of physical training in sarcoidosis patients. Moreover, psychological health and physical functions improved. Future studies are warranted to assess the benefits of physical training in sarcoidosis. (Sarcoidosis Vasc Diffuse Lung Dis 2015; 32: 53-62)
Keywords: sarcoidosis, fatigue, physical training, muscle strength, exercise capacity, quality of life
Original languageEnglish
Pages (from-to)53-62
JournalSarcoidosis Vasculitis and Diffuse Lung Diseases
Volume32
Issue number1
Publication statusPublished - 2015

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Marcellis, R. G. J., van der Veeke, M. A. F., Mesters, I., Drent, M., Bie, R. A., de Vries, J., & Lenssen, A. F. (2015). Does physical training reduce fatigue in sarcoidosis? Sarcoidosis Vasculitis and Diffuse Lung Diseases, 32(1), 53-62.
Marcellis, R. G. J. ; van der Veeke, M.A.F. ; Mesters, I. ; Drent, M. ; Bie, R.A. ; de Vries, Jolanda ; Lenssen, A.F. / Does physical training reduce fatigue in sarcoidosis?. In: Sarcoidosis Vasculitis and Diffuse Lung Diseases. 2015 ; Vol. 32, No. 1. pp. 53-62.
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title = "Does physical training reduce fatigue in sarcoidosis?",
abstract = "Background:Sarcoidosis patients frequently experience fatigue, exercise intolerance and muscle weakness, resulting in reduced quality of life (QOL). Scientific studies on the benefits of physical training in sarcoidosis have been scarce, so the aim of this pilot study was to examine the impact of a 13-week physical training program on fatigue, physical functions and QOL in fatigued sarcoidosis patients and/or patients with exercise intolerance. Methods:18 sarcoidosis patients participated in a 13-week physical training program. TheFatigue Assessment Scale (FAS), World Health Organization Quality of Life-BREF assessment instrument (WHOQOL-BREF),Medical Research Council (MRC) dyspnea scale, Visual Analogue Scale (VAS), six-minute walk test (6MWT), submaximal bicycle test and muscle strength of the quadriceps and elbow flexors were assessed at baseline and after the program.Results:FAS scores had decreased (mean difference -2.7 points, 95{\%} CI -4.4 to -1.1) after completion of the training program, along with improvements in WHOQOL-BREF psychological health domain (mean difference 0.9 points, 95{\%} CI 0.2 to 1.7) and MRC dyspnea score (mean difference -0.4 points, 95{\%} CI -0.8 to -0.1). 6MWD improved by 34.6 m (95{\%} CI 20.3 to 49.0) and mean heart rate on the bicycle test improved (mean difference 8.4 beats/minute, 95{\%} CI -13.8 to -3.0), as did quadriceps strength (mean difference 10.7 kg, 95{\%} CI 5.5 to 15.9). Conclusion:Fatigue reduced after a period of physical training in sarcoidosis patients. Moreover, psychological health and physical functions improved. Future studies are warranted to assess the benefits of physical training in sarcoidosis. (Sarcoidosis Vasc Diffuse Lung Dis 2015; 32: 53-62)Keywords: sarcoidosis, fatigue, physical training, muscle strength, exercise capacity, quality of life",
author = "Marcellis, {R. G. J.} and {van der Veeke}, M.A.F. and I. Mesters and M. Drent and R.A. Bie and {de Vries}, Jolanda and A.F. Lenssen",
year = "2015",
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Marcellis, RGJ, van der Veeke, MAF, Mesters, I, Drent, M, Bie, RA, de Vries, J & Lenssen, AF 2015, 'Does physical training reduce fatigue in sarcoidosis?', Sarcoidosis Vasculitis and Diffuse Lung Diseases, vol. 32, no. 1, pp. 53-62.

Does physical training reduce fatigue in sarcoidosis? / Marcellis, R. G. J.; van der Veeke, M.A.F.; Mesters, I.; Drent, M.; Bie, R.A.; de Vries, Jolanda; Lenssen, A.F.

In: Sarcoidosis Vasculitis and Diffuse Lung Diseases, Vol. 32, No. 1, 2015, p. 53-62.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Does physical training reduce fatigue in sarcoidosis?

AU - Marcellis, R. G. J.

AU - van der Veeke, M.A.F.

AU - Mesters, I.

AU - Drent, M.

AU - Bie, R.A.

AU - de Vries, Jolanda

AU - Lenssen, A.F.

PY - 2015

Y1 - 2015

N2 - Background:Sarcoidosis patients frequently experience fatigue, exercise intolerance and muscle weakness, resulting in reduced quality of life (QOL). Scientific studies on the benefits of physical training in sarcoidosis have been scarce, so the aim of this pilot study was to examine the impact of a 13-week physical training program on fatigue, physical functions and QOL in fatigued sarcoidosis patients and/or patients with exercise intolerance. Methods:18 sarcoidosis patients participated in a 13-week physical training program. TheFatigue Assessment Scale (FAS), World Health Organization Quality of Life-BREF assessment instrument (WHOQOL-BREF),Medical Research Council (MRC) dyspnea scale, Visual Analogue Scale (VAS), six-minute walk test (6MWT), submaximal bicycle test and muscle strength of the quadriceps and elbow flexors were assessed at baseline and after the program.Results:FAS scores had decreased (mean difference -2.7 points, 95% CI -4.4 to -1.1) after completion of the training program, along with improvements in WHOQOL-BREF psychological health domain (mean difference 0.9 points, 95% CI 0.2 to 1.7) and MRC dyspnea score (mean difference -0.4 points, 95% CI -0.8 to -0.1). 6MWD improved by 34.6 m (95% CI 20.3 to 49.0) and mean heart rate on the bicycle test improved (mean difference 8.4 beats/minute, 95% CI -13.8 to -3.0), as did quadriceps strength (mean difference 10.7 kg, 95% CI 5.5 to 15.9). Conclusion:Fatigue reduced after a period of physical training in sarcoidosis patients. Moreover, psychological health and physical functions improved. Future studies are warranted to assess the benefits of physical training in sarcoidosis. (Sarcoidosis Vasc Diffuse Lung Dis 2015; 32: 53-62)Keywords: sarcoidosis, fatigue, physical training, muscle strength, exercise capacity, quality of life

AB - Background:Sarcoidosis patients frequently experience fatigue, exercise intolerance and muscle weakness, resulting in reduced quality of life (QOL). Scientific studies on the benefits of physical training in sarcoidosis have been scarce, so the aim of this pilot study was to examine the impact of a 13-week physical training program on fatigue, physical functions and QOL in fatigued sarcoidosis patients and/or patients with exercise intolerance. Methods:18 sarcoidosis patients participated in a 13-week physical training program. TheFatigue Assessment Scale (FAS), World Health Organization Quality of Life-BREF assessment instrument (WHOQOL-BREF),Medical Research Council (MRC) dyspnea scale, Visual Analogue Scale (VAS), six-minute walk test (6MWT), submaximal bicycle test and muscle strength of the quadriceps and elbow flexors were assessed at baseline and after the program.Results:FAS scores had decreased (mean difference -2.7 points, 95% CI -4.4 to -1.1) after completion of the training program, along with improvements in WHOQOL-BREF psychological health domain (mean difference 0.9 points, 95% CI 0.2 to 1.7) and MRC dyspnea score (mean difference -0.4 points, 95% CI -0.8 to -0.1). 6MWD improved by 34.6 m (95% CI 20.3 to 49.0) and mean heart rate on the bicycle test improved (mean difference 8.4 beats/minute, 95% CI -13.8 to -3.0), as did quadriceps strength (mean difference 10.7 kg, 95% CI 5.5 to 15.9). Conclusion:Fatigue reduced after a period of physical training in sarcoidosis patients. Moreover, psychological health and physical functions improved. Future studies are warranted to assess the benefits of physical training in sarcoidosis. (Sarcoidosis Vasc Diffuse Lung Dis 2015; 32: 53-62)Keywords: sarcoidosis, fatigue, physical training, muscle strength, exercise capacity, quality of life

M3 - Article

VL - 32

SP - 53

EP - 62

JO - Sarcoidosis Vasculitis and Diffuse Lung Diseases

JF - Sarcoidosis Vasculitis and Diffuse Lung Diseases

SN - 1124-0490

IS - 1

ER -

Marcellis RGJ, van der Veeke MAF, Mesters I, Drent M, Bie RA, de Vries J et al. Does physical training reduce fatigue in sarcoidosis? Sarcoidosis Vasculitis and Diffuse Lung Diseases. 2015;32(1):53-62.