Dopamine D1 receptors and age differences in brain activation during working memory

L. Bäckman; S. Karlsson; H. Fischer; P. Karrison; Yvonne Brehmer; A. Rieckmann; S.W. MacDonald; L. Farde; L. Nyberg

doi:10.1016/j.neurobiolaging.2009.10.018

Dopamine D1 receptors and age differences in brain activation during working memory

L. Bäckman, S. Karlsson, H. Fischer, P. Karrison, Yvonne Brehmer, A. Rieckmann, S.W. MacDonald, L. Farde, L. Nyberg

Research output: Contribution to journal › Article › Scientific › peer-review

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Abstract

In an fMRI study, 20 younger and 20 healthy older adults were scanned while performing a spatial working-memory task under two levels of load. On a separate occasion, the same subjects underwent PET measurements using the radioligand [(11)C] SCH23390 to determine dopamine D(1) receptor binding potential (BP) in caudate nucleus and dorsolateral prefrontal cortex (DLPFC). The fMRI study revealed a significant load modulation of brain activity (higher load>lower load) in frontal and parietal regions for younger, but not older, adults. The PET measurements showed marked age-related reductions of D(1) BP in caudate and DLPFC. Statistical control of caudate and DLPFC D(1) binding eliminated the age-related reduction in load-dependent BOLD signal in left frontal cortex, and attenuated greatly the reduction in right frontal and left parietal cortex. These findings suggest that age-related alterations in dopaminergic neurotransmission may contribute to underrecruitment of task-relevant brain regions during working-memory performance in old age.

Original language	English
Pages (from-to)	1849-1856
Journal	Neurobiology of Aging
Volume	32
Issue number	10
DOIs	https://doi.org/10.1016/j.neurobiolaging.2009.10.018
Publication status	Published - 2011
Externally published	Yes

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title = "Dopamine D1 receptors and age differences in brain activation during working memory",

abstract = "In an fMRI study, 20 younger and 20 healthy older adults were scanned while performing a spatial working-memory task under two levels of load. On a separate occasion, the same subjects underwent PET measurements using the radioligand [(11)C] SCH23390 to determine dopamine D(1) receptor binding potential (BP) in caudate nucleus and dorsolateral prefrontal cortex (DLPFC). The fMRI study revealed a significant load modulation of brain activity (higher load>lower load) in frontal and parietal regions for younger, but not older, adults. The PET measurements showed marked age-related reductions of D(1) BP in caudate and DLPFC. Statistical control of caudate and DLPFC D(1) binding eliminated the age-related reduction in load-dependent BOLD signal in left frontal cortex, and attenuated greatly the reduction in right frontal and left parietal cortex. These findings suggest that age-related alterations in dopaminergic neurotransmission may contribute to underrecruitment of task-relevant brain regions during working-memory performance in old age.",

author = "L. B{\"a}ckman and S. Karlsson and H. Fischer and P. Karrison and Yvonne Brehmer and A. Rieckmann and S.W. MacDonald and L. Farde and L. Nyberg",

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T1 - Dopamine D1 receptors and age differences in brain activation during working memory

AU - Bäckman, L.

AU - Karlsson, S.

AU - Fischer, H.

AU - Karrison, P.

AU - Brehmer, Yvonne

AU - Rieckmann, A.

AU - MacDonald, S.W.

AU - Farde, L.

AU - Nyberg, L.

PY - 2011

Y1 - 2011

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AB - In an fMRI study, 20 younger and 20 healthy older adults were scanned while performing a spatial working-memory task under two levels of load. On a separate occasion, the same subjects underwent PET measurements using the radioligand [(11)C] SCH23390 to determine dopamine D(1) receptor binding potential (BP) in caudate nucleus and dorsolateral prefrontal cortex (DLPFC). The fMRI study revealed a significant load modulation of brain activity (higher load>lower load) in frontal and parietal regions for younger, but not older, adults. The PET measurements showed marked age-related reductions of D(1) BP in caudate and DLPFC. Statistical control of caudate and DLPFC D(1) binding eliminated the age-related reduction in load-dependent BOLD signal in left frontal cortex, and attenuated greatly the reduction in right frontal and left parietal cortex. These findings suggest that age-related alterations in dopaminergic neurotransmission may contribute to underrecruitment of task-relevant brain regions during working-memory performance in old age.

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DO - 10.1016/j.neurobiolaging.2009.10.018

M3 - Article

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EP - 1856

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - 10

ER -

Dopamine D1 receptors and age differences in brain activation during working memory

Abstract

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