Early infant neuromotor assessment is associated with language and nonverbal cognitive function in toddlers

The generation R study

T. van Batenburg-Eddes, J. Henrichs, J.J. Schenk, I. Sincer, L. de Groot, A. Hofman, V.W. Jaddoe, F.C. Verhulst, H.W. Tiemeier

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Objective:
Numerous studies in high-risk populations established that variations in infant neuromotor development predict poor cognitive function. It is unclear whether this association is found in the general population. Moreover, previous population-based studies mostly focused on motor milestone achievement.
Methods:
This study was embedded in the Generation R Study, a population-based cohort in Rotterdam, the Netherlands. Neuromotor development was assessed with an adapted version of Touwen's Neurodevelopmental Examination when infants (1205 males, 1278 females) were on average 12 weeks old (standard deviation 1, range, 9–15 weeks). To measure language function at age 1.5 years, the MacArthur Short Form Vocabulary Checklist was used. At 2.5 years, mothers completed the Language Development Survey and the Parent Report of Children's Abilities measuring language and nonverbal cognitive functioning, respectively.
Results:
After adjustment for confounders, less optimal neuromotor development, that is, more low tone symptoms, was associated with a delay in receptive language at 1.5 years (odds ratio [OR], 1.18; 95% confidence interval [CI], 1.05–1.34) and in expressive language at multiple time points (OR, 1.11; 95% CI, 1.02–1.21). Higher scores on overall neuromotor development, indicating a less optimal neuromotor development, was associated with an increased risk of a delay in nonverbal cognitive function at 2.5 years (OR, 1.19; 95% CI, 1.05–1.35).
Conclusions:
The results of this study suggest that infants with more low tone symptoms, indicating minor deviances from normal neuromotor development, are somewhat more vulnerable to language delays than those infants who do not have these symptoms.
Original languageEnglish
Pages (from-to)326-334
JournalJournal of Developmental & Behavioral Pediatrics
Volume34
Issue number5
DOIs
Publication statusPublished - 2013

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Language
Odds Ratio
Confidence Intervals
Language Development Disorders
Vocabulary
Checklist
Netherlands
Mothers

Cite this

van Batenburg-Eddes, T. ; Henrichs, J. ; Schenk, J.J. ; Sincer, I. ; de Groot, L. ; Hofman, A. ; Jaddoe, V.W. ; Verhulst, F.C. ; Tiemeier, H.W. / Early infant neuromotor assessment is associated with language and nonverbal cognitive function in toddlers : The generation R study. In: Journal of Developmental & Behavioral Pediatrics . 2013 ; Vol. 34, No. 5. pp. 326-334.
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title = "Early infant neuromotor assessment is associated with language and nonverbal cognitive function in toddlers: The generation R study",
abstract = "Objective: Numerous studies in high-risk populations established that variations in infant neuromotor development predict poor cognitive function. It is unclear whether this association is found in the general population. Moreover, previous population-based studies mostly focused on motor milestone achievement.Methods: This study was embedded in the Generation R Study, a population-based cohort in Rotterdam, the Netherlands. Neuromotor development was assessed with an adapted version of Touwen's Neurodevelopmental Examination when infants (1205 males, 1278 females) were on average 12 weeks old (standard deviation 1, range, 9–15 weeks). To measure language function at age 1.5 years, the MacArthur Short Form Vocabulary Checklist was used. At 2.5 years, mothers completed the Language Development Survey and the Parent Report of Children's Abilities measuring language and nonverbal cognitive functioning, respectively.Results: After adjustment for confounders, less optimal neuromotor development, that is, more low tone symptoms, was associated with a delay in receptive language at 1.5 years (odds ratio [OR], 1.18; 95{\%} confidence interval [CI], 1.05–1.34) and in expressive language at multiple time points (OR, 1.11; 95{\%} CI, 1.02–1.21). Higher scores on overall neuromotor development, indicating a less optimal neuromotor development, was associated with an increased risk of a delay in nonverbal cognitive function at 2.5 years (OR, 1.19; 95{\%} CI, 1.05–1.35).Conclusions: The results of this study suggest that infants with more low tone symptoms, indicating minor deviances from normal neuromotor development, are somewhat more vulnerable to language delays than those infants who do not have these symptoms.",
author = "{van Batenburg-Eddes}, T. and J. Henrichs and J.J. Schenk and I. Sincer and {de Groot}, L. and A. Hofman and V.W. Jaddoe and F.C. Verhulst and H.W. Tiemeier",
year = "2013",
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van Batenburg-Eddes, T, Henrichs, J, Schenk, JJ, Sincer, I, de Groot, L, Hofman, A, Jaddoe, VW, Verhulst, FC & Tiemeier, HW 2013, 'Early infant neuromotor assessment is associated with language and nonverbal cognitive function in toddlers: The generation R study', Journal of Developmental & Behavioral Pediatrics , vol. 34, no. 5, pp. 326-334. https://doi.org/10.1097/DBP.0b013e3182961e80

Early infant neuromotor assessment is associated with language and nonverbal cognitive function in toddlers : The generation R study. / van Batenburg-Eddes, T.; Henrichs, J.; Schenk, J.J.; Sincer, I.; de Groot, L.; Hofman, A.; Jaddoe, V.W.; Verhulst, F.C.; Tiemeier, H.W.

In: Journal of Developmental & Behavioral Pediatrics , Vol. 34, No. 5, 2013, p. 326-334.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Early infant neuromotor assessment is associated with language and nonverbal cognitive function in toddlers

T2 - The generation R study

AU - van Batenburg-Eddes, T.

AU - Henrichs, J.

AU - Schenk, J.J.

AU - Sincer, I.

AU - de Groot, L.

AU - Hofman, A.

AU - Jaddoe, V.W.

AU - Verhulst, F.C.

AU - Tiemeier, H.W.

PY - 2013

Y1 - 2013

N2 - Objective: Numerous studies in high-risk populations established that variations in infant neuromotor development predict poor cognitive function. It is unclear whether this association is found in the general population. Moreover, previous population-based studies mostly focused on motor milestone achievement.Methods: This study was embedded in the Generation R Study, a population-based cohort in Rotterdam, the Netherlands. Neuromotor development was assessed with an adapted version of Touwen's Neurodevelopmental Examination when infants (1205 males, 1278 females) were on average 12 weeks old (standard deviation 1, range, 9–15 weeks). To measure language function at age 1.5 years, the MacArthur Short Form Vocabulary Checklist was used. At 2.5 years, mothers completed the Language Development Survey and the Parent Report of Children's Abilities measuring language and nonverbal cognitive functioning, respectively.Results: After adjustment for confounders, less optimal neuromotor development, that is, more low tone symptoms, was associated with a delay in receptive language at 1.5 years (odds ratio [OR], 1.18; 95% confidence interval [CI], 1.05–1.34) and in expressive language at multiple time points (OR, 1.11; 95% CI, 1.02–1.21). Higher scores on overall neuromotor development, indicating a less optimal neuromotor development, was associated with an increased risk of a delay in nonverbal cognitive function at 2.5 years (OR, 1.19; 95% CI, 1.05–1.35).Conclusions: The results of this study suggest that infants with more low tone symptoms, indicating minor deviances from normal neuromotor development, are somewhat more vulnerable to language delays than those infants who do not have these symptoms.

AB - Objective: Numerous studies in high-risk populations established that variations in infant neuromotor development predict poor cognitive function. It is unclear whether this association is found in the general population. Moreover, previous population-based studies mostly focused on motor milestone achievement.Methods: This study was embedded in the Generation R Study, a population-based cohort in Rotterdam, the Netherlands. Neuromotor development was assessed with an adapted version of Touwen's Neurodevelopmental Examination when infants (1205 males, 1278 females) were on average 12 weeks old (standard deviation 1, range, 9–15 weeks). To measure language function at age 1.5 years, the MacArthur Short Form Vocabulary Checklist was used. At 2.5 years, mothers completed the Language Development Survey and the Parent Report of Children's Abilities measuring language and nonverbal cognitive functioning, respectively.Results: After adjustment for confounders, less optimal neuromotor development, that is, more low tone symptoms, was associated with a delay in receptive language at 1.5 years (odds ratio [OR], 1.18; 95% confidence interval [CI], 1.05–1.34) and in expressive language at multiple time points (OR, 1.11; 95% CI, 1.02–1.21). Higher scores on overall neuromotor development, indicating a less optimal neuromotor development, was associated with an increased risk of a delay in nonverbal cognitive function at 2.5 years (OR, 1.19; 95% CI, 1.05–1.35).Conclusions: The results of this study suggest that infants with more low tone symptoms, indicating minor deviances from normal neuromotor development, are somewhat more vulnerable to language delays than those infants who do not have these symptoms.

U2 - 10.1097/DBP.0b013e3182961e80

DO - 10.1097/DBP.0b013e3182961e80

M3 - Article

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EP - 334

JO - Journal of Developmental & Behavioral Pediatrics

JF - Journal of Developmental & Behavioral Pediatrics

SN - 0196-206X

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