Effect of physical training on QTc interval in elderly people

A.J. Schuit, J M Dekker, F de Vegt, T C Verheij, R D Rijneke, E G Schouten

Research output: Contribution to journalArticleScientificpeer-review

Abstract

In order to assess whether heart rate-adjusted QT duration (QTc) is reduced by physical activity in an elderly population, a randomized, controlled intervention study of the effect of a 6-month intensive training program on QTc was undertaken. The participants were 229 healthy men and women, aged 60-80 years. The subjects of the intervention group trained three to four times a week at a work load of about 70% of their maximum capacity for 6 months, while the control subjects maintained their habitual activities. The main outcome measures were change in QTc and resting heart rate. For women, the mean QTc interval (ms) of the intervention group changed by -6.7 (SE 2.8) versus 0.6 (SE 2.4) in the control group (P = .05), while for men, the change in the intervention group subjects was -2.7 (SE 2.2) versus 0.4 (SE 3.1) in the control subjects (P = .39). Also, resting heart rate (beats/ min) changed in intervention group women by -4.6 (SE 1.7) as against -0.06 (SE 1.1) in the control subjects (P = .02), and in intervention group men it changed by -3.2 (SE 1.2) versus -0.9 (SE 1.5) in the control subjects (P = .25). These data indicate that regular physical activity favorably affects QTc in elderly women. A similar, but not significant, trend was observed in men. The beneficial shift in QTc may be caused by a more favorable autonomic balance through increased parasympathetic activity. The reduced resting heart rate in subjects of the intervention group supports this view. Although the reduction was relatively small, it may represent a favorable effect on cardiovascular risk.

Original languageEnglish
Pages (from-to)111-116
JournalJournal of Electrocardiology
Volume31
Issue number2
Publication statusPublished - Apr 1998

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Keywords

  • Aged
  • Aged, 80 and over
  • Electrocardiography
  • Exercise Test
  • Female
  • Follow-Up Studies
  • Heart Conduction System
  • Heart Rate
  • Humans
  • Long QT Syndrome
  • Male
  • Middle Aged
  • Parasympathetic Nervous System
  • Physical Education and Training
  • Sex Factors
  • Signal Processing, Computer-Assisted
  • Sympathetic Nervous System
  • Treatment Outcome
  • Clinical Trial
  • Comparative Study
  • Journal Article
  • Randomized Controlled Trial

Cite this

Schuit, A. J., Dekker, J. M., de Vegt, F., Verheij, T. C., Rijneke, R. D., & Schouten, E. G. (1998). Effect of physical training on QTc interval in elderly people. Journal of Electrocardiology, 31(2), 111-116.
Schuit, A.J. ; Dekker, J M ; de Vegt, F ; Verheij, T C ; Rijneke, R D ; Schouten, E G. / Effect of physical training on QTc interval in elderly people. In: Journal of Electrocardiology. 1998 ; Vol. 31, No. 2. pp. 111-116.
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abstract = "In order to assess whether heart rate-adjusted QT duration (QTc) is reduced by physical activity in an elderly population, a randomized, controlled intervention study of the effect of a 6-month intensive training program on QTc was undertaken. The participants were 229 healthy men and women, aged 60-80 years. The subjects of the intervention group trained three to four times a week at a work load of about 70{\%} of their maximum capacity for 6 months, while the control subjects maintained their habitual activities. The main outcome measures were change in QTc and resting heart rate. For women, the mean QTc interval (ms) of the intervention group changed by -6.7 (SE 2.8) versus 0.6 (SE 2.4) in the control group (P = .05), while for men, the change in the intervention group subjects was -2.7 (SE 2.2) versus 0.4 (SE 3.1) in the control subjects (P = .39). Also, resting heart rate (beats/ min) changed in intervention group women by -4.6 (SE 1.7) as against -0.06 (SE 1.1) in the control subjects (P = .02), and in intervention group men it changed by -3.2 (SE 1.2) versus -0.9 (SE 1.5) in the control subjects (P = .25). These data indicate that regular physical activity favorably affects QTc in elderly women. A similar, but not significant, trend was observed in men. The beneficial shift in QTc may be caused by a more favorable autonomic balance through increased parasympathetic activity. The reduced resting heart rate in subjects of the intervention group supports this view. Although the reduction was relatively small, it may represent a favorable effect on cardiovascular risk.",
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Schuit, AJ, Dekker, JM, de Vegt, F, Verheij, TC, Rijneke, RD & Schouten, EG 1998, 'Effect of physical training on QTc interval in elderly people', Journal of Electrocardiology, vol. 31, no. 2, pp. 111-116.

Effect of physical training on QTc interval in elderly people. / Schuit, A.J.; Dekker, J M; de Vegt, F; Verheij, T C; Rijneke, R D; Schouten, E G.

In: Journal of Electrocardiology, Vol. 31, No. 2, 04.1998, p. 111-116.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Effect of physical training on QTc interval in elderly people

AU - Schuit, A.J.

AU - Dekker, J M

AU - de Vegt, F

AU - Verheij, T C

AU - Rijneke, R D

AU - Schouten, E G

PY - 1998/4

Y1 - 1998/4

N2 - In order to assess whether heart rate-adjusted QT duration (QTc) is reduced by physical activity in an elderly population, a randomized, controlled intervention study of the effect of a 6-month intensive training program on QTc was undertaken. The participants were 229 healthy men and women, aged 60-80 years. The subjects of the intervention group trained three to four times a week at a work load of about 70% of their maximum capacity for 6 months, while the control subjects maintained their habitual activities. The main outcome measures were change in QTc and resting heart rate. For women, the mean QTc interval (ms) of the intervention group changed by -6.7 (SE 2.8) versus 0.6 (SE 2.4) in the control group (P = .05), while for men, the change in the intervention group subjects was -2.7 (SE 2.2) versus 0.4 (SE 3.1) in the control subjects (P = .39). Also, resting heart rate (beats/ min) changed in intervention group women by -4.6 (SE 1.7) as against -0.06 (SE 1.1) in the control subjects (P = .02), and in intervention group men it changed by -3.2 (SE 1.2) versus -0.9 (SE 1.5) in the control subjects (P = .25). These data indicate that regular physical activity favorably affects QTc in elderly women. A similar, but not significant, trend was observed in men. The beneficial shift in QTc may be caused by a more favorable autonomic balance through increased parasympathetic activity. The reduced resting heart rate in subjects of the intervention group supports this view. Although the reduction was relatively small, it may represent a favorable effect on cardiovascular risk.

AB - In order to assess whether heart rate-adjusted QT duration (QTc) is reduced by physical activity in an elderly population, a randomized, controlled intervention study of the effect of a 6-month intensive training program on QTc was undertaken. The participants were 229 healthy men and women, aged 60-80 years. The subjects of the intervention group trained three to four times a week at a work load of about 70% of their maximum capacity for 6 months, while the control subjects maintained their habitual activities. The main outcome measures were change in QTc and resting heart rate. For women, the mean QTc interval (ms) of the intervention group changed by -6.7 (SE 2.8) versus 0.6 (SE 2.4) in the control group (P = .05), while for men, the change in the intervention group subjects was -2.7 (SE 2.2) versus 0.4 (SE 3.1) in the control subjects (P = .39). Also, resting heart rate (beats/ min) changed in intervention group women by -4.6 (SE 1.7) as against -0.06 (SE 1.1) in the control subjects (P = .02), and in intervention group men it changed by -3.2 (SE 1.2) versus -0.9 (SE 1.5) in the control subjects (P = .25). These data indicate that regular physical activity favorably affects QTc in elderly women. A similar, but not significant, trend was observed in men. The beneficial shift in QTc may be caused by a more favorable autonomic balance through increased parasympathetic activity. The reduced resting heart rate in subjects of the intervention group supports this view. Although the reduction was relatively small, it may represent a favorable effect on cardiovascular risk.

KW - Aged

KW - Aged, 80 and over

KW - Electrocardiography

KW - Exercise Test

KW - Female

KW - Follow-Up Studies

KW - Heart Conduction System

KW - Heart Rate

KW - Humans

KW - Long QT Syndrome

KW - Male

KW - Middle Aged

KW - Parasympathetic Nervous System

KW - Physical Education and Training

KW - Sex Factors

KW - Signal Processing, Computer-Assisted

KW - Sympathetic Nervous System

KW - Treatment Outcome

KW - Clinical Trial

KW - Comparative Study

KW - Journal Article

KW - Randomized Controlled Trial

M3 - Article

VL - 31

SP - 111

EP - 116

JO - Journal of Electrocardiology

JF - Journal of Electrocardiology

SN - 0022-0736

IS - 2

ER -

Schuit AJ, Dekker JM, de Vegt F, Verheij TC, Rijneke RD, Schouten EG. Effect of physical training on QTc interval in elderly people. Journal of Electrocardiology. 1998 Apr;31(2):111-116.