Effect of strenuous exercise on fibrinogen and fibrinolysis in healthy elderly men and women

A J Schuit, E G Schouten, C Kluft, M de Maat, P P Menheere, F J Kok

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The elevated incidence of thrombotic disease in elderly people may be associated with an increase in PAI-1 and fibrinogen with ageing. Cross-sectional studies report an inverse relation of PAI-1 and fibrinogen with physical activity, but training studies show inconsistent results. In a controlled intervention study among elderly subjects (aged 60-80 years) we observed a moderate decrease in PAI-1 antigen (4%, -2.1 +/- 2.4 ng/ml), a significant increase in t-PA activity (11%, 0.07 +/- 0.04 IU/ml) and an unexpected significant increase in fibrinogen (6%, 0.18 +/- 0.07 g/l) in subjects following a 6-month intensive training program as compared to controls. Reduction in PAI-1 antigen was significantly associated with a decrease in triglycerides (beta = 10.3 ng/ml per 1 mM, p <0.01) and insulin (beta = 2.37 ng/ml per 1 mU/l, p = 0.07). Increase in fibrinogen coincided with a rise in C-reactive protein (p <0.001). These data suggest that regular intensive activity may increase fibrinolytic activity in a moderate way, but also may cause chronically elevated plasma levels of acute phase proteins in elderly persons.

Original languageEnglish
Pages (from-to)845-851
JournalThrombosis and Haemostasis
Issue number2
Publication statusPublished - Aug 1997
Externally publishedYes


  • Aged
  • Aged, 80 and over
  • Body Weight
  • Exercise
  • Female
  • Fibrinogen
  • Fibrinolysis
  • Humans
  • Male
  • Middle Aged
  • Journal Article


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