Effect of strenuous exercise on fibrinogen and fibrinolysis in healthy elderly men and women

A J Schuit, E G Schouten, C Kluft, M de Maat, P P Menheere, F J Kok

Research output: Contribution to journalArticleScientificpeer-review

Abstract

The elevated incidence of thrombotic disease in elderly people may be associated with an increase in PAI-1 and fibrinogen with ageing. Cross-sectional studies report an inverse relation of PAI-1 and fibrinogen with physical activity, but training studies show inconsistent results. In a controlled intervention study among elderly subjects (aged 60-80 years) we observed a moderate decrease in PAI-1 antigen (4%, -2.1 +/- 2.4 ng/ml), a significant increase in t-PA activity (11%, 0.07 +/- 0.04 IU/ml) and an unexpected significant increase in fibrinogen (6%, 0.18 +/- 0.07 g/l) in subjects following a 6-month intensive training program as compared to controls. Reduction in PAI-1 antigen was significantly associated with a decrease in triglycerides (beta = 10.3 ng/ml per 1 mM, p <0.01) and insulin (beta = 2.37 ng/ml per 1 mU/l, p = 0.07). Increase in fibrinogen coincided with a rise in C-reactive protein (p <0.001). These data suggest that regular intensive activity may increase fibrinolytic activity in a moderate way, but also may cause chronically elevated plasma levels of acute phase proteins in elderly persons.

Original languageEnglish
Pages (from-to)845-851
JournalThrombosis and Haemostasis
Volume78
Issue number2
Publication statusPublished - Aug 1997
Externally publishedYes

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Plasminogen Activator Inhibitor 1
Fibrinolysis
Exercise
Cross-Sectional Studies
Education
Incidence

Keywords

  • Aged
  • Aged, 80 and over
  • Body Weight
  • Exercise
  • Female
  • Fibrinogen
  • Fibrinolysis
  • Humans
  • Male
  • Middle Aged
  • Journal Article

Cite this

Schuit, A. J., Schouten, E. G., Kluft, C., de Maat, M., Menheere, P. P., & Kok, F. J. (1997). Effect of strenuous exercise on fibrinogen and fibrinolysis in healthy elderly men and women. Thrombosis and Haemostasis, 78(2), 845-851.
Schuit, A J ; Schouten, E G ; Kluft, C ; de Maat, M ; Menheere, P P ; Kok, F J. / Effect of strenuous exercise on fibrinogen and fibrinolysis in healthy elderly men and women. In: Thrombosis and Haemostasis. 1997 ; Vol. 78, No. 2. pp. 845-851.
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Schuit, AJ, Schouten, EG, Kluft, C, de Maat, M, Menheere, PP & Kok, FJ 1997, 'Effect of strenuous exercise on fibrinogen and fibrinolysis in healthy elderly men and women', Thrombosis and Haemostasis, vol. 78, no. 2, pp. 845-851.

Effect of strenuous exercise on fibrinogen and fibrinolysis in healthy elderly men and women. / Schuit, A J; Schouten, E G; Kluft, C; de Maat, M; Menheere, P P; Kok, F J.

In: Thrombosis and Haemostasis, Vol. 78, No. 2, 08.1997, p. 845-851.

Research output: Contribution to journalArticleScientificpeer-review

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AU - Schuit, A J

AU - Schouten, E G

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AU - Menheere, P P

AU - Kok, F J

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AB - The elevated incidence of thrombotic disease in elderly people may be associated with an increase in PAI-1 and fibrinogen with ageing. Cross-sectional studies report an inverse relation of PAI-1 and fibrinogen with physical activity, but training studies show inconsistent results. In a controlled intervention study among elderly subjects (aged 60-80 years) we observed a moderate decrease in PAI-1 antigen (4%, -2.1 +/- 2.4 ng/ml), a significant increase in t-PA activity (11%, 0.07 +/- 0.04 IU/ml) and an unexpected significant increase in fibrinogen (6%, 0.18 +/- 0.07 g/l) in subjects following a 6-month intensive training program as compared to controls. Reduction in PAI-1 antigen was significantly associated with a decrease in triglycerides (beta = 10.3 ng/ml per 1 mM, p <0.01) and insulin (beta = 2.37 ng/ml per 1 mU/l, p = 0.07). Increase in fibrinogen coincided with a rise in C-reactive protein (p <0.001). These data suggest that regular intensive activity may increase fibrinolytic activity in a moderate way, but also may cause chronically elevated plasma levels of acute phase proteins in elderly persons.

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