Effect of vitamin D supplementation on health status in non-vitamin D deficient people with type 2 diabetes mellitus

S. Westra, Y.H. Krul-Poel , H.J. van Wijland, M.M. ter Wee, F. Stam, P. Lips, F. Pouwer, S. Simsek

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Abstract

Objective
Increased levels of depressive symptoms, fatigue or pain (all dimensions of reduced health-related quality of life (HRQOL)) are common in people with type 2 diabetes mellitus (DM). Earlier studies have reported associations between low vitamin D status and fatigue and depressive symptoms. The aim of the present study was to examine the effects of vitamin D supplementation on dimensions of HRQOL in people with type 2 DM.
Design
Randomised, double-blind, placebo-controlled trial.
Methods
The effect of monthly cholecalciferol 50,000 IU vs placebo on HRQOL was assessed in 275 adults with type 2 DM derived from general practices. HRQOL at baseline and after six months using the Short Form 36 Health Survey (SF-36) was collected. Linear regression analyses were used to compare the change in HRQOL over time between the vitamin D and placebo group.
Results
187/275 (68%) completed baseline and follow-up SF-36 and were included in the analysis. Median serum 25-hydroxyvitamin D almost doubled in the intervention group compared to that in the placebo group (58.5–106.0 nmol/L vs 60.0–61.5 nmol/L, respectively). A small significant difference (adjusted B: −8.90; 95% CI: −17.16 to −0.65) between both groups was seen concerning the SF-36 domain role limitations due to physical problems in disadvantage of the vitamin D group.
Conclusions
Six months of vitamin D supplementation did not improve HRQOL in non-vitamin D-deficient people with type 2 DM managed on oral antidiabetic therapy.
Keywords: RCT vitamin D health-related quality of life type 2 diabetes mellitus
Original languageDutch
Pages (from-to)61-69
JournalEndocrine Connections
Volume5
Issue number6
DOIs
Publication statusPublished - Nov 2016

Cite this

Westra, S., Krul-Poel , Y. H., van Wijland, H. J., ter Wee, M. M., Stam, F., Lips, P., Pouwer, F., & Simsek, S. (2016). Effect of vitamin D supplementation on health status in non-vitamin D deficient people with type 2 diabetes mellitus. Endocrine Connections, 5(6), 61-69. https://doi.org/10.1530/EC-16-0070