Effect of weight loss with or without exercise on inflammatory markers and adipokines in postmenopausal women: The SHAPE-2 trial, A randomized controlled trial

Willemijn A van Gemert, Anne M May, A.J. Schuit, Blanche Y M Oosterhof, Petra H Peeters, Evelyn M Monninkhof

Research output: Contribution to journalArticleScientificpeer-review

23 Citations (Scopus)

Abstract

Background:

We investigated the effect of equivalent weight loss, by a hypocaloric diet or mainly exercise, on inflammatory markers and adipokines in overweight postmenopausal women.

Methods:

Women were randomized to a diet (n = 97), mainly exercise (n = 98), or control group (n = 48). Goal of both interventions was to lose 5 to 6 kg bodyweight by a hypocaloric diet or an exercise program (4 hours/week) combined with a small caloric intake restriction. Outcomes after 16 weeks included serum high-sensitive C-reactive protein (hsCRP), IL6, adiponectin, and leptin.

Results:

Both intervention groups achieved the target weight loss. Controls remained weight stable. Compared with control, hsCRP decreased with mainly exercise [treatment effect ratio (TER) = 0.64] and borderline statistically significant with diet (TER = 0.77). There was a suggestively larger effect of exercise, directly compared with diet (TER = 0.83). Leptin decreased with both interventions: mainly exercise (TER = 0.55) and diet (TER = 0.59), versus control. Effects attenuated and lost significance after adjusting for change in body fat percentage, and to a lesser extent when adjusting for fitness. No effects were seen on IL6 and adiponectin.

Conclusions:

A 16-week randomized intervention inducing comparable weight loss by a hypocaloric diet or mainly exercise, resulted in favorable effects on serum hsCRP and leptin. We found a possible more beneficial effect on hsCRP with mainly exercise versus diet. These effects of exercise were established by changes in body fat percentage and physical fitness.

Impact:

A modest amount of weight loss in postmenopausal women reduces hsCRP and leptin levels which might be associated with a lower breast cancer risk.

Original languageEnglish
Pages (from-to)799-806
JournalCancer Epidemiology, Biomarkers & Prevention
Volume25
Issue number5
DOIs
Publication statusPublished - May 2016
Externally publishedYes

Keywords

  • Adipokines
  • Biomarkers
  • Exercise
  • Female
  • Humans
  • Middle Aged
  • Postmenopause
  • Treatment Outcome
  • Weight Loss
  • Journal Article
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

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