Effect of weight loss with or without exercise on inflammatory markers and adipokines in postmenopausal women

The SHAPE-2 trial, A randomized controlled trial

Willemijn A van Gemert, Anne M May, A.J. Schuit, Blanche Y M Oosterhof, Petra H Peeters, Evelyn M Monninkhof

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Background:

We investigated the effect of equivalent weight loss, by a hypocaloric diet or mainly exercise, on inflammatory markers and adipokines in overweight postmenopausal women.

Methods:

Women were randomized to a diet (n = 97), mainly exercise (n = 98), or control group (n = 48). Goal of both interventions was to lose 5 to 6 kg bodyweight by a hypocaloric diet or an exercise program (4 hours/week) combined with a small caloric intake restriction. Outcomes after 16 weeks included serum high-sensitive C-reactive protein (hsCRP), IL6, adiponectin, and leptin.

Results:

Both intervention groups achieved the target weight loss. Controls remained weight stable. Compared with control, hsCRP decreased with mainly exercise [treatment effect ratio (TER) = 0.64] and borderline statistically significant with diet (TER = 0.77). There was a suggestively larger effect of exercise, directly compared with diet (TER = 0.83). Leptin decreased with both interventions: mainly exercise (TER = 0.55) and diet (TER = 0.59), versus control. Effects attenuated and lost significance after adjusting for change in body fat percentage, and to a lesser extent when adjusting for fitness. No effects were seen on IL6 and adiponectin.

Conclusions:

A 16-week randomized intervention inducing comparable weight loss by a hypocaloric diet or mainly exercise, resulted in favorable effects on serum hsCRP and leptin. We found a possible more beneficial effect on hsCRP with mainly exercise versus diet. These effects of exercise were established by changes in body fat percentage and physical fitness.

Impact:

A modest amount of weight loss in postmenopausal women reduces hsCRP and leptin levels which might be associated with a lower breast cancer risk.

Original languageEnglish
Pages (from-to)799-806
JournalCancer Epidemiology, Biomarkers & Prevention
Volume25
Issue number5
DOIs
Publication statusPublished - May 2016
Externally publishedYes

Fingerprint

Exercise
Leptin
Adiponectin
Adipose Tissue
Interleukin-6
Caloric Restriction
Serum
Weights and Measures

Keywords

  • Adipokines
  • Biomarkers
  • Exercise
  • Female
  • Humans
  • Middle Aged
  • Postmenopause
  • Treatment Outcome
  • Weight Loss
  • Journal Article
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

Cite this

van Gemert, Willemijn A ; May, Anne M ; Schuit, A.J. ; Oosterhof, Blanche Y M ; Peeters, Petra H ; Monninkhof, Evelyn M. / Effect of weight loss with or without exercise on inflammatory markers and adipokines in postmenopausal women : The SHAPE-2 trial, A randomized controlled trial. In: Cancer Epidemiology, Biomarkers & Prevention . 2016 ; Vol. 25, No. 5. pp. 799-806.
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abstract = "Background: We investigated the effect of equivalent weight loss, by a hypocaloric diet or mainly exercise, on inflammatory markers and adipokines in overweight postmenopausal women.Methods:Women were randomized to a diet (n = 97), mainly exercise (n = 98), or control group (n = 48). Goal of both interventions was to lose 5 to 6 kg bodyweight by a hypocaloric diet or an exercise program (4 hours/week) combined with a small caloric intake restriction. Outcomes after 16 weeks included serum high-sensitive C-reactive protein (hsCRP), IL6, adiponectin, and leptin.Results: Both intervention groups achieved the target weight loss. Controls remained weight stable. Compared with control, hsCRP decreased with mainly exercise [treatment effect ratio (TER) = 0.64] and borderline statistically significant with diet (TER = 0.77). There was a suggestively larger effect of exercise, directly compared with diet (TER = 0.83). Leptin decreased with both interventions: mainly exercise (TER = 0.55) and diet (TER = 0.59), versus control. Effects attenuated and lost significance after adjusting for change in body fat percentage, and to a lesser extent when adjusting for fitness. No effects were seen on IL6 and adiponectin.Conclusions: A 16-week randomized intervention inducing comparable weight loss by a hypocaloric diet or mainly exercise, resulted in favorable effects on serum hsCRP and leptin. We found a possible more beneficial effect on hsCRP with mainly exercise versus diet. These effects of exercise were established by changes in body fat percentage and physical fitness.Impact: A modest amount of weight loss in postmenopausal women reduces hsCRP and leptin levels which might be associated with a lower breast cancer risk.",
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Effect of weight loss with or without exercise on inflammatory markers and adipokines in postmenopausal women : The SHAPE-2 trial, A randomized controlled trial. / van Gemert, Willemijn A; May, Anne M; Schuit, A.J.; Oosterhof, Blanche Y M; Peeters, Petra H; Monninkhof, Evelyn M.

In: Cancer Epidemiology, Biomarkers & Prevention , Vol. 25, No. 5, 05.2016, p. 799-806.

Research output: Contribution to journalArticleScientificpeer-review

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T1 - Effect of weight loss with or without exercise on inflammatory markers and adipokines in postmenopausal women

T2 - The SHAPE-2 trial, A randomized controlled trial

AU - van Gemert, Willemijn A

AU - May, Anne M

AU - Schuit, A.J.

AU - Oosterhof, Blanche Y M

AU - Peeters, Petra H

AU - Monninkhof, Evelyn M

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AB - Background: We investigated the effect of equivalent weight loss, by a hypocaloric diet or mainly exercise, on inflammatory markers and adipokines in overweight postmenopausal women.Methods:Women were randomized to a diet (n = 97), mainly exercise (n = 98), or control group (n = 48). Goal of both interventions was to lose 5 to 6 kg bodyweight by a hypocaloric diet or an exercise program (4 hours/week) combined with a small caloric intake restriction. Outcomes after 16 weeks included serum high-sensitive C-reactive protein (hsCRP), IL6, adiponectin, and leptin.Results: Both intervention groups achieved the target weight loss. Controls remained weight stable. Compared with control, hsCRP decreased with mainly exercise [treatment effect ratio (TER) = 0.64] and borderline statistically significant with diet (TER = 0.77). There was a suggestively larger effect of exercise, directly compared with diet (TER = 0.83). Leptin decreased with both interventions: mainly exercise (TER = 0.55) and diet (TER = 0.59), versus control. Effects attenuated and lost significance after adjusting for change in body fat percentage, and to a lesser extent when adjusting for fitness. No effects were seen on IL6 and adiponectin.Conclusions: A 16-week randomized intervention inducing comparable weight loss by a hypocaloric diet or mainly exercise, resulted in favorable effects on serum hsCRP and leptin. We found a possible more beneficial effect on hsCRP with mainly exercise versus diet. These effects of exercise were established by changes in body fat percentage and physical fitness.Impact: A modest amount of weight loss in postmenopausal women reduces hsCRP and leptin levels which might be associated with a lower breast cancer risk.

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KW - Biomarkers

KW - Exercise

KW - Female

KW - Humans

KW - Middle Aged

KW - Postmenopause

KW - Treatment Outcome

KW - Weight Loss

KW - Journal Article

KW - Randomized Controlled Trial

KW - Research Support, Non-U.S. Gov't

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VL - 25

SP - 799

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JO - Cancer Epidemiology, Biomarkers & Prevention

JF - Cancer Epidemiology, Biomarkers & Prevention

SN - 1055-9965

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ER -