Epigenome-Wide Association Studies in Psychiatry: Achievements and Problems

K. Bassil, N. Ali, E. Pishva, D.L.A. van den Hove

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Abstract

Genetic variation can only explain a small portion of risk to psychiatric disorders, including major depressive disorder, schizophrenia, and post-traumatic stress disorder. Epidemiological studies are increasingly showing a link between environmental factors and the development of various psychiatric disorders, mainly mediated by underlying epigenetic mechanisms. DNA methylation is one of the most studied epigenetic mechanisms in psychiatric disorders. Epigenome-wide association studies (EWAS) typically used to study changes in DNA methylation still face methodological challenges and limitations at both the fundamental, technical, and data analysis levels. In this chapter, we offer a brief overview of some EWAS studies in different psychiatric disorders and discuss the current challenges, pitfalls, and future considerations for this field.
Original languageEnglish
Title of host publicationEpigenetic Epidemiology
PublisherSpringer Nature Switzerland AG
Pages424-444
ISBN (Print)9783030944742, 9783030944759
DOIs
Publication statusPublished - 2022
Externally publishedYes

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