Fatty acid biomarkers of dairy fat consumption and incidence of type 2 diabetes: A pooled analysis of prospective cohort studies

Fumiaki Imamura, Amanda Fretts, Matti Marklund, Andres V. Ardisson Korat, Wei-sin Yang, Maria Lankinen, Waqas Qureshi, Catherine Helmer, Tzu-an Chen, Kerry Wong, Julie K. Bassett, Rachel Murphy, Nathan Tintle, Chaoyu Ian Yu, Ingeborg A. Brouwer, Kuo-liong Chien, Alexis C. Frazier-wood, Liana C. Del Gobbo, Luc Djoussé, Johanna M. Geleijnse & 29 others Graham G. Giles, Janette De Goede, Vilmundur Gudnason, William S. Harris, Allison Hodge, Frank Hu, Albert Koulman, Markku Laakso, Lars Lind, Hung-ju Lin, Barbara Mcknight, Kalina Rajaobelina, Ulf Risérus, Jennifer G. Robinson, Cécilia Samieri, David S. Siscovick, S.S. Soedamah-Muthu, Nona Sotoodehnia, Qi Sun, Michael Y. Tsai, Matti Uusitupa, Lynne E. Wagenknecht, Nick J. Wareham, Jason Hy Wu, Renata Micha, Nita G. Forouhi, Rozenn N. Lemaitre, Dariush Mozaffarian, Andrew T Hattersley

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Abstract

Background
We aimed to investigate prospective associations of circulating or adipose tissue odd-chain fatty acids 15:0 and 17:0 and trans-palmitoleic acid, t16:1n-7, as potential biomarkers of dairy fat intake, with incident type 2 diabetes (T2D).
Methods and Findings
Sixteen prospective cohorts from 12 countries (7 from the United States, 7 from Europe, 1 from Australia, 1 from Taiwan) performed new harmonised individual-level analysis for the prospective associations according to a standardised plan. In total, 63,682 participants with a broad range of baseline ages and BMIs and 15,180 incident cases of T2D over the average of 9 years of follow-up were evaluated. Study-specific results were pooled using inverse-variance-weighted meta-analysis. Prespecified interactions by age, sex, BMI, and race/ethnicity were explored in each cohort and were meta-analysed. Potential heterogeneity by cohort-specific characteristics (regions, lipid compartments used for fatty acid assays) was assessed with metaregression. After adjustment for potential confounders, including measures of adiposity (BMI, waist circumference) and lipogenesis (levels of palmitate, triglycerides), higher levels of 15:0, 17:0, and t16:1n-7 were associated with lower incidence of T2D. In the most adjusted model, the hazard ratio (95% CI) for incident T2D per cohort-specific 10th to 90th percentile range of 15:0 was 0.80 (0.73-0.87); of 17:0, 0.65 (0.59-0.72); of t16:1n7, 0.82 (0.70-0.96); and of their sum, 0.71 (0.63-0.79). In exploratory analyses, similar associations for 15:0, 17:0, and the sum of all three fatty acids were present in both genders but stronger in women than in men (pinteraction < 0.001). Whereas studying associations with biomarkers has several advantages, as limitations, the biomarkers do not distinguish between different food sources of dairy fat (e.g., cheese, yogurt, milk), and residual confounding by unmeasured or imprecisely measured confounders may exist.
Conclusions
In a large meta-analysis that pooled the findings from 16 prospective cohort studies, higher levels of 15:0, 17:0, and t16:1n-7 were associated with a lower risk of T2D
Original languageEnglish
Article numbere1002670
JournalPLOS Medicine
Volume15
Issue number10
DOIs
Publication statusPublished - 2018

Fingerprint

Type 2 Diabetes Mellitus
Fatty Acids
Fats
Incidence
Yogurt
Lipogenesis
Palmitates
Adiposity
Cheese
Proportional Hazards Models
Adipose Tissue
Lipids

Keywords

  • ADIPOSE-TISSUE
  • BRANCHED-CHAIN
  • CONTROLLED-TRIALS
  • DIETARY RECOMMENDATIONS
  • DOSE-RESPONSE METAANALYSIS
  • EPIC-INTERACT
  • POOLING PROJECT
  • PRODUCT INTAKE
  • TRANS-PALMITOLEIC ACID
  • UNITED-STATES

Cite this

Imamura, F., Fretts, A., Marklund, M., Ardisson Korat, A. V., Yang, W., Lankinen, M., ... Hattersley, A. T. (Ed.) (2018). Fatty acid biomarkers of dairy fat consumption and incidence of type 2 diabetes: A pooled analysis of prospective cohort studies. PLOS Medicine, 15(10), [e1002670]. https://doi.org/10.1371/journal.pmed.1002670
Imamura, Fumiaki ; Fretts, Amanda ; Marklund, Matti ; Ardisson Korat, Andres V. ; Yang, Wei-sin ; Lankinen, Maria ; Qureshi, Waqas ; Helmer, Catherine ; Chen, Tzu-an ; Wong, Kerry ; Bassett, Julie K. ; Murphy, Rachel ; Tintle, Nathan ; Yu, Chaoyu Ian ; Brouwer, Ingeborg A. ; Chien, Kuo-liong ; Frazier-wood, Alexis C. ; Del Gobbo, Liana C. ; Djoussé, Luc ; Geleijnse, Johanna M. ; Giles, Graham G. ; De Goede, Janette ; Gudnason, Vilmundur ; Harris, William S. ; Hodge, Allison ; Hu, Frank ; Koulman, Albert ; Laakso, Markku ; Lind, Lars ; Lin, Hung-ju ; Mcknight, Barbara ; Rajaobelina, Kalina ; Risérus, Ulf ; Robinson, Jennifer G. ; Samieri, Cécilia ; Siscovick, David S. ; Soedamah-Muthu, S.S. ; Sotoodehnia, Nona ; Sun, Qi ; Tsai, Michael Y. ; Uusitupa, Matti ; Wagenknecht, Lynne E. ; Wareham, Nick J. ; Wu, Jason Hy ; Micha, Renata ; Forouhi, Nita G. ; Lemaitre, Rozenn N. ; Mozaffarian, Dariush ; Hattersley, Andrew T (Editor). / Fatty acid biomarkers of dairy fat consumption and incidence of type 2 diabetes : A pooled analysis of prospective cohort studies. In: PLOS Medicine. 2018 ; Vol. 15, No. 10.
@article{3a3d56f8a7c04a05ad5f748048f2968e,
title = "Fatty acid biomarkers of dairy fat consumption and incidence of type 2 diabetes: A pooled analysis of prospective cohort studies",
abstract = "BackgroundWe aimed to investigate prospective associations of circulating or adipose tissue odd-chain fatty acids 15:0 and 17:0 and trans-palmitoleic acid, t16:1n-7, as potential biomarkers of dairy fat intake, with incident type 2 diabetes (T2D).Methods and FindingsSixteen prospective cohorts from 12 countries (7 from the United States, 7 from Europe, 1 from Australia, 1 from Taiwan) performed new harmonised individual-level analysis for the prospective associations according to a standardised plan. In total, 63,682 participants with a broad range of baseline ages and BMIs and 15,180 incident cases of T2D over the average of 9 years of follow-up were evaluated. Study-specific results were pooled using inverse-variance-weighted meta-analysis. Prespecified interactions by age, sex, BMI, and race/ethnicity were explored in each cohort and were meta-analysed. Potential heterogeneity by cohort-specific characteristics (regions, lipid compartments used for fatty acid assays) was assessed with metaregression. After adjustment for potential confounders, including measures of adiposity (BMI, waist circumference) and lipogenesis (levels of palmitate, triglycerides), higher levels of 15:0, 17:0, and t16:1n-7 were associated with lower incidence of T2D. In the most adjusted model, the hazard ratio (95{\%} CI) for incident T2D per cohort-specific 10th to 90th percentile range of 15:0 was 0.80 (0.73-0.87); of 17:0, 0.65 (0.59-0.72); of t16:1n7, 0.82 (0.70-0.96); and of their sum, 0.71 (0.63-0.79). In exploratory analyses, similar associations for 15:0, 17:0, and the sum of all three fatty acids were present in both genders but stronger in women than in men (pinteraction < 0.001). Whereas studying associations with biomarkers has several advantages, as limitations, the biomarkers do not distinguish between different food sources of dairy fat (e.g., cheese, yogurt, milk), and residual confounding by unmeasured or imprecisely measured confounders may exist.ConclusionsIn a large meta-analysis that pooled the findings from 16 prospective cohort studies, higher levels of 15:0, 17:0, and t16:1n-7 were associated with a lower risk of T2D",
keywords = "ADIPOSE-TISSUE, BRANCHED-CHAIN, CONTROLLED-TRIALS, DIETARY RECOMMENDATIONS, DOSE-RESPONSE METAANALYSIS, EPIC-INTERACT, POOLING PROJECT, PRODUCT INTAKE, TRANS-PALMITOLEIC ACID, UNITED-STATES",
author = "Fumiaki Imamura and Amanda Fretts and Matti Marklund and {Ardisson Korat}, {Andres V.} and Wei-sin Yang and Maria Lankinen and Waqas Qureshi and Catherine Helmer and Tzu-an Chen and Kerry Wong and Bassett, {Julie K.} and Rachel Murphy and Nathan Tintle and Yu, {Chaoyu Ian} and Brouwer, {Ingeborg A.} and Kuo-liong Chien and Frazier-wood, {Alexis C.} and {Del Gobbo}, {Liana C.} and Luc Djouss{\'e} and Geleijnse, {Johanna M.} and Giles, {Graham G.} and {De Goede}, Janette and Vilmundur Gudnason and Harris, {William S.} and Allison Hodge and Frank Hu and Albert Koulman and Markku Laakso and Lars Lind and Hung-ju Lin and Barbara Mcknight and Kalina Rajaobelina and Ulf Ris{\'e}rus and Robinson, {Jennifer G.} and C{\'e}cilia Samieri and Siscovick, {David S.} and S.S. Soedamah-Muthu and Nona Sotoodehnia and Qi Sun and Tsai, {Michael Y.} and Matti Uusitupa and Wagenknecht, {Lynne E.} and Wareham, {Nick J.} and Wu, {Jason Hy} and Renata Micha and Forouhi, {Nita G.} and Lemaitre, {Rozenn N.} and Dariush Mozaffarian and Hattersley, {Andrew T}",
year = "2018",
doi = "10.1371/journal.pmed.1002670",
language = "English",
volume = "15",
journal = "PLOS Medicine",
issn = "1549-1277",
publisher = "Nature Publishing Group",
number = "10",

}

Imamura, F, Fretts, A, Marklund, M, Ardisson Korat, AV, Yang, W, Lankinen, M, Qureshi, W, Helmer, C, Chen, T, Wong, K, Bassett, JK, Murphy, R, Tintle, N, Yu, CI, Brouwer, IA, Chien, K, Frazier-wood, AC, Del Gobbo, LC, Djoussé, L, Geleijnse, JM, Giles, GG, De Goede, J, Gudnason, V, Harris, WS, Hodge, A, Hu, F, Koulman, A, Laakso, M, Lind, L, Lin, H, Mcknight, B, Rajaobelina, K, Risérus, U, Robinson, JG, Samieri, C, Siscovick, DS, Soedamah-Muthu, SS, Sotoodehnia, N, Sun, Q, Tsai, MY, Uusitupa, M, Wagenknecht, LE, Wareham, NJ, Wu, JH, Micha, R, Forouhi, NG, Lemaitre, RN, Mozaffarian, D & Hattersley, AT (ed.) 2018, 'Fatty acid biomarkers of dairy fat consumption and incidence of type 2 diabetes: A pooled analysis of prospective cohort studies' PLOS Medicine, vol. 15, no. 10, e1002670. https://doi.org/10.1371/journal.pmed.1002670

Fatty acid biomarkers of dairy fat consumption and incidence of type 2 diabetes : A pooled analysis of prospective cohort studies. / Imamura, Fumiaki; Fretts, Amanda; Marklund, Matti; Ardisson Korat, Andres V.; Yang, Wei-sin; Lankinen, Maria; Qureshi, Waqas; Helmer, Catherine; Chen, Tzu-an; Wong, Kerry; Bassett, Julie K.; Murphy, Rachel; Tintle, Nathan; Yu, Chaoyu Ian; Brouwer, Ingeborg A.; Chien, Kuo-liong; Frazier-wood, Alexis C.; Del Gobbo, Liana C.; Djoussé, Luc; Geleijnse, Johanna M.; Giles, Graham G.; De Goede, Janette; Gudnason, Vilmundur; Harris, William S.; Hodge, Allison; Hu, Frank; Koulman, Albert; Laakso, Markku; Lind, Lars; Lin, Hung-ju; Mcknight, Barbara; Rajaobelina, Kalina; Risérus, Ulf; Robinson, Jennifer G.; Samieri, Cécilia; Siscovick, David S.; Soedamah-Muthu, S.S.; Sotoodehnia, Nona; Sun, Qi; Tsai, Michael Y.; Uusitupa, Matti; Wagenknecht, Lynne E.; Wareham, Nick J.; Wu, Jason Hy; Micha, Renata; Forouhi, Nita G.; Lemaitre, Rozenn N.; Mozaffarian, Dariush; Hattersley, Andrew T (Editor).

In: PLOS Medicine, Vol. 15, No. 10, e1002670, 2018.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Fatty acid biomarkers of dairy fat consumption and incidence of type 2 diabetes

T2 - A pooled analysis of prospective cohort studies

AU - Imamura, Fumiaki

AU - Fretts, Amanda

AU - Marklund, Matti

AU - Ardisson Korat, Andres V.

AU - Yang, Wei-sin

AU - Lankinen, Maria

AU - Qureshi, Waqas

AU - Helmer, Catherine

AU - Chen, Tzu-an

AU - Wong, Kerry

AU - Bassett, Julie K.

AU - Murphy, Rachel

AU - Tintle, Nathan

AU - Yu, Chaoyu Ian

AU - Brouwer, Ingeborg A.

AU - Chien, Kuo-liong

AU - Frazier-wood, Alexis C.

AU - Del Gobbo, Liana C.

AU - Djoussé, Luc

AU - Geleijnse, Johanna M.

AU - Giles, Graham G.

AU - De Goede, Janette

AU - Gudnason, Vilmundur

AU - Harris, William S.

AU - Hodge, Allison

AU - Hu, Frank

AU - Koulman, Albert

AU - Laakso, Markku

AU - Lind, Lars

AU - Lin, Hung-ju

AU - Mcknight, Barbara

AU - Rajaobelina, Kalina

AU - Risérus, Ulf

AU - Robinson, Jennifer G.

AU - Samieri, Cécilia

AU - Siscovick, David S.

AU - Soedamah-Muthu, S.S.

AU - Sotoodehnia, Nona

AU - Sun, Qi

AU - Tsai, Michael Y.

AU - Uusitupa, Matti

AU - Wagenknecht, Lynne E.

AU - Wareham, Nick J.

AU - Wu, Jason Hy

AU - Micha, Renata

AU - Forouhi, Nita G.

AU - Lemaitre, Rozenn N.

AU - Mozaffarian, Dariush

A2 - Hattersley, Andrew T

PY - 2018

Y1 - 2018

N2 - BackgroundWe aimed to investigate prospective associations of circulating or adipose tissue odd-chain fatty acids 15:0 and 17:0 and trans-palmitoleic acid, t16:1n-7, as potential biomarkers of dairy fat intake, with incident type 2 diabetes (T2D).Methods and FindingsSixteen prospective cohorts from 12 countries (7 from the United States, 7 from Europe, 1 from Australia, 1 from Taiwan) performed new harmonised individual-level analysis for the prospective associations according to a standardised plan. In total, 63,682 participants with a broad range of baseline ages and BMIs and 15,180 incident cases of T2D over the average of 9 years of follow-up were evaluated. Study-specific results were pooled using inverse-variance-weighted meta-analysis. Prespecified interactions by age, sex, BMI, and race/ethnicity were explored in each cohort and were meta-analysed. Potential heterogeneity by cohort-specific characteristics (regions, lipid compartments used for fatty acid assays) was assessed with metaregression. After adjustment for potential confounders, including measures of adiposity (BMI, waist circumference) and lipogenesis (levels of palmitate, triglycerides), higher levels of 15:0, 17:0, and t16:1n-7 were associated with lower incidence of T2D. In the most adjusted model, the hazard ratio (95% CI) for incident T2D per cohort-specific 10th to 90th percentile range of 15:0 was 0.80 (0.73-0.87); of 17:0, 0.65 (0.59-0.72); of t16:1n7, 0.82 (0.70-0.96); and of their sum, 0.71 (0.63-0.79). In exploratory analyses, similar associations for 15:0, 17:0, and the sum of all three fatty acids were present in both genders but stronger in women than in men (pinteraction < 0.001). Whereas studying associations with biomarkers has several advantages, as limitations, the biomarkers do not distinguish between different food sources of dairy fat (e.g., cheese, yogurt, milk), and residual confounding by unmeasured or imprecisely measured confounders may exist.ConclusionsIn a large meta-analysis that pooled the findings from 16 prospective cohort studies, higher levels of 15:0, 17:0, and t16:1n-7 were associated with a lower risk of T2D

AB - BackgroundWe aimed to investigate prospective associations of circulating or adipose tissue odd-chain fatty acids 15:0 and 17:0 and trans-palmitoleic acid, t16:1n-7, as potential biomarkers of dairy fat intake, with incident type 2 diabetes (T2D).Methods and FindingsSixteen prospective cohorts from 12 countries (7 from the United States, 7 from Europe, 1 from Australia, 1 from Taiwan) performed new harmonised individual-level analysis for the prospective associations according to a standardised plan. In total, 63,682 participants with a broad range of baseline ages and BMIs and 15,180 incident cases of T2D over the average of 9 years of follow-up were evaluated. Study-specific results were pooled using inverse-variance-weighted meta-analysis. Prespecified interactions by age, sex, BMI, and race/ethnicity were explored in each cohort and were meta-analysed. Potential heterogeneity by cohort-specific characteristics (regions, lipid compartments used for fatty acid assays) was assessed with metaregression. After adjustment for potential confounders, including measures of adiposity (BMI, waist circumference) and lipogenesis (levels of palmitate, triglycerides), higher levels of 15:0, 17:0, and t16:1n-7 were associated with lower incidence of T2D. In the most adjusted model, the hazard ratio (95% CI) for incident T2D per cohort-specific 10th to 90th percentile range of 15:0 was 0.80 (0.73-0.87); of 17:0, 0.65 (0.59-0.72); of t16:1n7, 0.82 (0.70-0.96); and of their sum, 0.71 (0.63-0.79). In exploratory analyses, similar associations for 15:0, 17:0, and the sum of all three fatty acids were present in both genders but stronger in women than in men (pinteraction < 0.001). Whereas studying associations with biomarkers has several advantages, as limitations, the biomarkers do not distinguish between different food sources of dairy fat (e.g., cheese, yogurt, milk), and residual confounding by unmeasured or imprecisely measured confounders may exist.ConclusionsIn a large meta-analysis that pooled the findings from 16 prospective cohort studies, higher levels of 15:0, 17:0, and t16:1n-7 were associated with a lower risk of T2D

KW - ADIPOSE-TISSUE

KW - BRANCHED-CHAIN

KW - CONTROLLED-TRIALS

KW - DIETARY RECOMMENDATIONS

KW - DOSE-RESPONSE METAANALYSIS

KW - EPIC-INTERACT

KW - POOLING PROJECT

KW - PRODUCT INTAKE

KW - TRANS-PALMITOLEIC ACID

KW - UNITED-STATES

U2 - 10.1371/journal.pmed.1002670

DO - 10.1371/journal.pmed.1002670

M3 - Article

VL - 15

JO - PLOS Medicine

JF - PLOS Medicine

SN - 1549-1277

IS - 10

M1 - e1002670

ER -