Feasibility of a home-based exercise intervention with remote guidance for patients with stable grade II and III gliomas

A pilot randomized controlled trial

K. Gehring, C.J.J. Kloek, Neil K Aaronson, K. Janssen, Lee Jones, M.M. Sitskoorn, M. Stuiver

Research output: Contribution to journalArticleScientificpeer-review

19 Downloads (Pure)

Abstract

Objective:
In this pilot study, we investigated the feasibility of a home-based, remotely guided exercise intervention for patients with gliomas.
Design:
Pilot randomized controlled trial (RCT) with randomization (2:1) to exercise or control group.
Subjects:
Patients with stable grade II and III gliomas.
Intervention:
The six-month intervention included three home-based exercise sessions per week at 60%–85% of maximum heart rate. Participants wore heart rate monitors connected to an online platform to record activities that were monitored weekly by the physiotherapist.
Main measures:
Accrual, attrition, adherence, safety, satisfaction, patient-reported physical activity, VO2 peak (by maximal cardiopulmonary exercise testing) and body mass index (BMI) at baseline and at six-month follow-up.
Results:
In all, 34 of 136 eligible patients (25%) were randomized to exercise training (N = 23) or the control group (N = 11), of whom 19 and 9, respectively, underwent follow-up. Mean adherence to prescribed sessions was 79%. Patients’ experiences were positive. There were no adverse events. Compared to the control group, the exercise group showed larger improvements in absolute VO2 peak (+158.9 mL/min; 95% CI: −44.8 to 362.5) and BMI (−0.3 kg/m²; 95% CI: −0.9 to 0.2). The median increase in physical activity was 1489 metabolic equivalent of task (MET) minutes higher in the exercise group. The most reported reasons for non-participation were lack of motivation or time.
Conclusion:
This innovative and intensive home-based exercise intervention was feasible in a small subset of patients with stable gliomas who were interested in exercising. The observed effects suggest that the programme may improve cardiorespiratory fitness. These results support the need for large-scale trials of exercise interventions in brain tumour patients.
Keywords: Glioma, brain tumour, exercise, physical training, physical fitness
Original languageEnglish
Pages (from-to)352–366
JournalClinical Rehabilitation
Volume32
Issue number3
DOIs
Publication statusPublished - 2018

Fingerprint

Glioma
Exercise
Body Mass Index
Physical Therapists

Keywords

  • BRAIN
  • CANCER SURVIVORS
  • COGNITION
  • FITNESS
  • Glioma
  • HEALTH SURVEY
  • HEART
  • OLDER-ADULTS
  • PHYSICAL-ACTIVITY
  • QUESTIONNAIRE
  • SF-36
  • brain tumour
  • exercise
  • physical fitness
  • physical training

Cite this

Gehring, K. ; Kloek, C.J.J. ; Aaronson, Neil K ; Janssen, K. ; Jones, Lee ; Sitskoorn, M.M. ; Stuiver, M. / Feasibility of a home-based exercise intervention with remote guidance for patients with stable grade II and III gliomas : A pilot randomized controlled trial. In: Clinical Rehabilitation. 2018 ; Vol. 32, No. 3. pp. 352–366.
@article{2b5a8092994441c0980a4e5b24943327,
title = "Feasibility of a home-based exercise intervention with remote guidance for patients with stable grade II and III gliomas: A pilot randomized controlled trial",
abstract = "Objective:In this pilot study, we investigated the feasibility of a home-based, remotely guided exercise intervention for patients with gliomas.Design:Pilot randomized controlled trial (RCT) with randomization (2:1) to exercise or control group.Subjects:Patients with stable grade II and III gliomas.Intervention:The six-month intervention included three home-based exercise sessions per week at 60{\%}–85{\%} of maximum heart rate. Participants wore heart rate monitors connected to an online platform to record activities that were monitored weekly by the physiotherapist.Main measures:Accrual, attrition, adherence, safety, satisfaction, patient-reported physical activity, VO2 peak (by maximal cardiopulmonary exercise testing) and body mass index (BMI) at baseline and at six-month follow-up.Results:In all, 34 of 136 eligible patients (25{\%}) were randomized to exercise training (N = 23) or the control group (N = 11), of whom 19 and 9, respectively, underwent follow-up. Mean adherence to prescribed sessions was 79{\%}. Patients’ experiences were positive. There were no adverse events. Compared to the control group, the exercise group showed larger improvements in absolute VO2 peak (+158.9 mL/min; 95{\%} CI: −44.8 to 362.5) and BMI (−0.3 kg/m²; 95{\%} CI: −0.9 to 0.2). The median increase in physical activity was 1489 metabolic equivalent of task (MET) minutes higher in the exercise group. The most reported reasons for non-participation were lack of motivation or time.Conclusion:This innovative and intensive home-based exercise intervention was feasible in a small subset of patients with stable gliomas who were interested in exercising. The observed effects suggest that the programme may improve cardiorespiratory fitness. These results support the need for large-scale trials of exercise interventions in brain tumour patients.Keywords: Glioma, brain tumour, exercise, physical training, physical fitness",
keywords = "BRAIN, CANCER SURVIVORS, COGNITION, FITNESS, Glioma, HEALTH SURVEY, HEART, OLDER-ADULTS, PHYSICAL-ACTIVITY, QUESTIONNAIRE, SF-36, brain tumour, exercise, physical fitness, physical training",
author = "K. Gehring and C.J.J. Kloek and Aaronson, {Neil K} and K. Janssen and Lee Jones and M.M. Sitskoorn and M. Stuiver",
year = "2018",
doi = "10.1177/0269215517728326",
language = "English",
volume = "32",
pages = "352–366",
journal = "Clinical Rehabilitation",
issn = "0269-2155",
publisher = "Sage Publications Ltd",
number = "3",

}

Feasibility of a home-based exercise intervention with remote guidance for patients with stable grade II and III gliomas : A pilot randomized controlled trial. / Gehring, K.; Kloek, C.J.J.; Aaronson, Neil K; Janssen, K.; Jones, Lee; Sitskoorn, M.M.; Stuiver, M.

In: Clinical Rehabilitation, Vol. 32, No. 3, 2018, p. 352–366.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Feasibility of a home-based exercise intervention with remote guidance for patients with stable grade II and III gliomas

T2 - A pilot randomized controlled trial

AU - Gehring, K.

AU - Kloek, C.J.J.

AU - Aaronson, Neil K

AU - Janssen, K.

AU - Jones, Lee

AU - Sitskoorn, M.M.

AU - Stuiver, M.

PY - 2018

Y1 - 2018

N2 - Objective:In this pilot study, we investigated the feasibility of a home-based, remotely guided exercise intervention for patients with gliomas.Design:Pilot randomized controlled trial (RCT) with randomization (2:1) to exercise or control group.Subjects:Patients with stable grade II and III gliomas.Intervention:The six-month intervention included three home-based exercise sessions per week at 60%–85% of maximum heart rate. Participants wore heart rate monitors connected to an online platform to record activities that were monitored weekly by the physiotherapist.Main measures:Accrual, attrition, adherence, safety, satisfaction, patient-reported physical activity, VO2 peak (by maximal cardiopulmonary exercise testing) and body mass index (BMI) at baseline and at six-month follow-up.Results:In all, 34 of 136 eligible patients (25%) were randomized to exercise training (N = 23) or the control group (N = 11), of whom 19 and 9, respectively, underwent follow-up. Mean adherence to prescribed sessions was 79%. Patients’ experiences were positive. There were no adverse events. Compared to the control group, the exercise group showed larger improvements in absolute VO2 peak (+158.9 mL/min; 95% CI: −44.8 to 362.5) and BMI (−0.3 kg/m²; 95% CI: −0.9 to 0.2). The median increase in physical activity was 1489 metabolic equivalent of task (MET) minutes higher in the exercise group. The most reported reasons for non-participation were lack of motivation or time.Conclusion:This innovative and intensive home-based exercise intervention was feasible in a small subset of patients with stable gliomas who were interested in exercising. The observed effects suggest that the programme may improve cardiorespiratory fitness. These results support the need for large-scale trials of exercise interventions in brain tumour patients.Keywords: Glioma, brain tumour, exercise, physical training, physical fitness

AB - Objective:In this pilot study, we investigated the feasibility of a home-based, remotely guided exercise intervention for patients with gliomas.Design:Pilot randomized controlled trial (RCT) with randomization (2:1) to exercise or control group.Subjects:Patients with stable grade II and III gliomas.Intervention:The six-month intervention included three home-based exercise sessions per week at 60%–85% of maximum heart rate. Participants wore heart rate monitors connected to an online platform to record activities that were monitored weekly by the physiotherapist.Main measures:Accrual, attrition, adherence, safety, satisfaction, patient-reported physical activity, VO2 peak (by maximal cardiopulmonary exercise testing) and body mass index (BMI) at baseline and at six-month follow-up.Results:In all, 34 of 136 eligible patients (25%) were randomized to exercise training (N = 23) or the control group (N = 11), of whom 19 and 9, respectively, underwent follow-up. Mean adherence to prescribed sessions was 79%. Patients’ experiences were positive. There were no adverse events. Compared to the control group, the exercise group showed larger improvements in absolute VO2 peak (+158.9 mL/min; 95% CI: −44.8 to 362.5) and BMI (−0.3 kg/m²; 95% CI: −0.9 to 0.2). The median increase in physical activity was 1489 metabolic equivalent of task (MET) minutes higher in the exercise group. The most reported reasons for non-participation were lack of motivation or time.Conclusion:This innovative and intensive home-based exercise intervention was feasible in a small subset of patients with stable gliomas who were interested in exercising. The observed effects suggest that the programme may improve cardiorespiratory fitness. These results support the need for large-scale trials of exercise interventions in brain tumour patients.Keywords: Glioma, brain tumour, exercise, physical training, physical fitness

KW - BRAIN

KW - CANCER SURVIVORS

KW - COGNITION

KW - FITNESS

KW - Glioma

KW - HEALTH SURVEY

KW - HEART

KW - OLDER-ADULTS

KW - PHYSICAL-ACTIVITY

KW - QUESTIONNAIRE

KW - SF-36

KW - brain tumour

KW - exercise

KW - physical fitness

KW - physical training

U2 - 10.1177/0269215517728326

DO - 10.1177/0269215517728326

M3 - Article

VL - 32

SP - 352

EP - 366

JO - Clinical Rehabilitation

JF - Clinical Rehabilitation

SN - 0269-2155

IS - 3

ER -