Feasibility of a home-based exercise intervention with remote guidance for patients with stable grade II and III gliomas: A pilot randomized controlled trial

K. Gehring, C.J.J. Kloek, Neil K Aaronson, K. Janssen, Lee Jones, M.M. Sitskoorn, M. Stuiver

Research output: Contribution to journalArticleScientificpeer-review

19 Downloads (Pure)

Abstract

Objective:
In this pilot study, we investigated the feasibility of a home-based, remotely guided exercise intervention for patients with gliomas.
Design:
Pilot randomized controlled trial (RCT) with randomization (2:1) to exercise or control group.
Subjects:
Patients with stable grade II and III gliomas.
Intervention:
The six-month intervention included three home-based exercise sessions per week at 60%–85% of maximum heart rate. Participants wore heart rate monitors connected to an online platform to record activities that were monitored weekly by the physiotherapist.
Main measures:
Accrual, attrition, adherence, safety, satisfaction, patient-reported physical activity, VO2 peak (by maximal cardiopulmonary exercise testing) and body mass index (BMI) at baseline and at six-month follow-up.
Results:
In all, 34 of 136 eligible patients (25%) were randomized to exercise training (N = 23) or the control group (N = 11), of whom 19 and 9, respectively, underwent follow-up. Mean adherence to prescribed sessions was 79%. Patients’ experiences were positive. There were no adverse events. Compared to the control group, the exercise group showed larger improvements in absolute VO2 peak (+158.9 mL/min; 95% CI: −44.8 to 362.5) and BMI (−0.3 kg/m²; 95% CI: −0.9 to 0.2). The median increase in physical activity was 1489 metabolic equivalent of task (MET) minutes higher in the exercise group. The most reported reasons for non-participation were lack of motivation or time.
Conclusion:
This innovative and intensive home-based exercise intervention was feasible in a small subset of patients with stable gliomas who were interested in exercising. The observed effects suggest that the programme may improve cardiorespiratory fitness. These results support the need for large-scale trials of exercise interventions in brain tumour patients.
Keywords: Glioma, brain tumour, exercise, physical training, physical fitness
Original languageEnglish
Pages (from-to)352–366
JournalClinical Rehabilitation
Volume32
Issue number3
DOIs
Publication statusPublished - 2018

    Fingerprint

Keywords

  • BRAIN
  • CANCER SURVIVORS
  • COGNITION
  • FITNESS
  • Glioma
  • HEALTH SURVEY
  • HEART
  • OLDER-ADULTS
  • PHYSICAL-ACTIVITY
  • QUESTIONNAIRE
  • SF-36
  • brain tumour
  • exercise
  • physical fitness
  • physical training

Cite this